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Role of resting metabolic rate and energy expenditure in hunger and appetite control: a new formulation

A long-running issue in appetite research concerns the influence of energy expenditure on energy intake. More than 50 years ago, Otto G. Edholm proposed that “the differences between the intakes of food [of individuals] must originate in differences in the expenditure of energy”. However, a relation...

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Autores principales: Blundell, John E., Caudwell, Phillipa, Gibbons, Catherine, Hopkins, Mark, Naslund, Erik, King, Neil, Finlayson, Graham
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Limited 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3424457/
https://www.ncbi.nlm.nih.gov/pubmed/22915022
http://dx.doi.org/10.1242/dmm.009837
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author Blundell, John E.
Caudwell, Phillipa
Gibbons, Catherine
Hopkins, Mark
Naslund, Erik
King, Neil
Finlayson, Graham
author_facet Blundell, John E.
Caudwell, Phillipa
Gibbons, Catherine
Hopkins, Mark
Naslund, Erik
King, Neil
Finlayson, Graham
author_sort Blundell, John E.
collection PubMed
description A long-running issue in appetite research concerns the influence of energy expenditure on energy intake. More than 50 years ago, Otto G. Edholm proposed that “the differences between the intakes of food [of individuals] must originate in differences in the expenditure of energy”. However, a relationship between energy expenditure and energy intake within any one day could not be found, although there was a correlation over 2 weeks. This issue was never resolved before interest in integrative biology was replaced by molecular biochemistry. Using a psychobiological approach, we have studied appetite control in an energy balance framework using a multi-level experimental system on a single cohort of overweight and obese human subjects. This has disclosed relationships between variables in the domains of body composition [fat-free mass (FFM), fat mass (FM)], metabolism, gastrointestinal hormones, hunger and energy intake. In this Commentary, we review our own and other data, and discuss a new formulation whereby appetite control and energy intake are regulated by energy expenditure. Specifically, we propose that FFM (the largest contributor to resting metabolic rate), but not body mass index or FM, is closely associated with self-determined meal size and daily energy intake. This formulation has implications for understanding weight regulation and the management of obesity.
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spelling pubmed-34244572012-09-01 Role of resting metabolic rate and energy expenditure in hunger and appetite control: a new formulation Blundell, John E. Caudwell, Phillipa Gibbons, Catherine Hopkins, Mark Naslund, Erik King, Neil Finlayson, Graham Dis Model Mech Commentary A long-running issue in appetite research concerns the influence of energy expenditure on energy intake. More than 50 years ago, Otto G. Edholm proposed that “the differences between the intakes of food [of individuals] must originate in differences in the expenditure of energy”. However, a relationship between energy expenditure and energy intake within any one day could not be found, although there was a correlation over 2 weeks. This issue was never resolved before interest in integrative biology was replaced by molecular biochemistry. Using a psychobiological approach, we have studied appetite control in an energy balance framework using a multi-level experimental system on a single cohort of overweight and obese human subjects. This has disclosed relationships between variables in the domains of body composition [fat-free mass (FFM), fat mass (FM)], metabolism, gastrointestinal hormones, hunger and energy intake. In this Commentary, we review our own and other data, and discuss a new formulation whereby appetite control and energy intake are regulated by energy expenditure. Specifically, we propose that FFM (the largest contributor to resting metabolic rate), but not body mass index or FM, is closely associated with self-determined meal size and daily energy intake. This formulation has implications for understanding weight regulation and the management of obesity. The Company of Biologists Limited 2012-09 /pmc/articles/PMC3424457/ /pubmed/22915022 http://dx.doi.org/10.1242/dmm.009837 Text en © 2012. Published by The Company of Biologists Ltd This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial Share Alike License (http://creativecommons.org/licenses/by-nc-sa/3.0), which permits unrestricted non-commercial use, distribution and reproduction in any medium provided that the original work is properly cited and all further distributions of the work or adaptation are subject to the same Creative Commons License terms.
spellingShingle Commentary
Blundell, John E.
Caudwell, Phillipa
Gibbons, Catherine
Hopkins, Mark
Naslund, Erik
King, Neil
Finlayson, Graham
Role of resting metabolic rate and energy expenditure in hunger and appetite control: a new formulation
title Role of resting metabolic rate and energy expenditure in hunger and appetite control: a new formulation
title_full Role of resting metabolic rate and energy expenditure in hunger and appetite control: a new formulation
title_fullStr Role of resting metabolic rate and energy expenditure in hunger and appetite control: a new formulation
title_full_unstemmed Role of resting metabolic rate and energy expenditure in hunger and appetite control: a new formulation
title_short Role of resting metabolic rate and energy expenditure in hunger and appetite control: a new formulation
title_sort role of resting metabolic rate and energy expenditure in hunger and appetite control: a new formulation
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3424457/
https://www.ncbi.nlm.nih.gov/pubmed/22915022
http://dx.doi.org/10.1242/dmm.009837
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