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Postnatal maternal separation modifies the response to an obesogenic diet in adulthood in rats
An early-life adverse environment has been implicated in the susceptibility to different diseases in adulthood, such as mental disorders, diabetes and obesity. We analyzed the effects of a high-fat sucrose (HFS) diet for 35 days in adult female rats that had experienced 180 minutes daily of maternal...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Company of Biologists Limited
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3424467/ https://www.ncbi.nlm.nih.gov/pubmed/22773756 http://dx.doi.org/10.1242/dmm.009043 |
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author | Paternain, Laura Martisova, Eva Milagro, Fermín I. Ramírez, María J. Martínez, J. Alfredo Campión, Javier |
author_facet | Paternain, Laura Martisova, Eva Milagro, Fermín I. Ramírez, María J. Martínez, J. Alfredo Campión, Javier |
author_sort | Paternain, Laura |
collection | PubMed |
description | An early-life adverse environment has been implicated in the susceptibility to different diseases in adulthood, such as mental disorders, diabetes and obesity. We analyzed the effects of a high-fat sucrose (HFS) diet for 35 days in adult female rats that had experienced 180 minutes daily of maternal separation (MS) during lactancy. Changes in the obesity phenotype, biochemical profile, levels of glucocorticoid metabolism biomarkers, and the expression of different obesity- and glucocorticoid-metabolism-related genes were analyzed in periovaric adipose tissue. HFS intake increased body weight, adiposity and serum leptin levels, whereas MS decreased fat pad masses but only in rats fed an HFS diet. MS reduced insulin resistance markers but only in chow-fed rats. Corticosterone and estradiol serum levels did not change in this experimental model. A multiple gene expression analysis revealed that the expression of adiponutrin (Adpn) was increased owing to MS, and an interaction between HFS diet intake and MS was observed in the mRNA levels of leptin (Lep) and peroxisome proliferator-activated receptor gamma coactivator 1 alpha (Ppargc1a). These results revealed that early-life stress affects the response to an HFS diet later in life, and that this response can lead to phenotype and transcriptomic changes. |
format | Online Article Text |
id | pubmed-3424467 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | The Company of Biologists Limited |
record_format | MEDLINE/PubMed |
spelling | pubmed-34244672012-09-01 Postnatal maternal separation modifies the response to an obesogenic diet in adulthood in rats Paternain, Laura Martisova, Eva Milagro, Fermín I. Ramírez, María J. Martínez, J. Alfredo Campión, Javier Dis Model Mech Research Report An early-life adverse environment has been implicated in the susceptibility to different diseases in adulthood, such as mental disorders, diabetes and obesity. We analyzed the effects of a high-fat sucrose (HFS) diet for 35 days in adult female rats that had experienced 180 minutes daily of maternal separation (MS) during lactancy. Changes in the obesity phenotype, biochemical profile, levels of glucocorticoid metabolism biomarkers, and the expression of different obesity- and glucocorticoid-metabolism-related genes were analyzed in periovaric adipose tissue. HFS intake increased body weight, adiposity and serum leptin levels, whereas MS decreased fat pad masses but only in rats fed an HFS diet. MS reduced insulin resistance markers but only in chow-fed rats. Corticosterone and estradiol serum levels did not change in this experimental model. A multiple gene expression analysis revealed that the expression of adiponutrin (Adpn) was increased owing to MS, and an interaction between HFS diet intake and MS was observed in the mRNA levels of leptin (Lep) and peroxisome proliferator-activated receptor gamma coactivator 1 alpha (Ppargc1a). These results revealed that early-life stress affects the response to an HFS diet later in life, and that this response can lead to phenotype and transcriptomic changes. The Company of Biologists Limited 2012-09 2012-07-05 /pmc/articles/PMC3424467/ /pubmed/22773756 http://dx.doi.org/10.1242/dmm.009043 Text en © 2012. Published by The Company of Biologists Ltd This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial Share Alike License (http://creativecommons.org/licenses/by-nc-sa/3.0), which permits unrestricted non-commercial use, distribution and reproduction in any medium provided that the original work is properly cited and all further distributions of the work or adaptation are subject to the same Creative Commons License terms. |
spellingShingle | Research Report Paternain, Laura Martisova, Eva Milagro, Fermín I. Ramírez, María J. Martínez, J. Alfredo Campión, Javier Postnatal maternal separation modifies the response to an obesogenic diet in adulthood in rats |
title | Postnatal maternal separation modifies the response to an obesogenic diet in adulthood in rats |
title_full | Postnatal maternal separation modifies the response to an obesogenic diet in adulthood in rats |
title_fullStr | Postnatal maternal separation modifies the response to an obesogenic diet in adulthood in rats |
title_full_unstemmed | Postnatal maternal separation modifies the response to an obesogenic diet in adulthood in rats |
title_short | Postnatal maternal separation modifies the response to an obesogenic diet in adulthood in rats |
title_sort | postnatal maternal separation modifies the response to an obesogenic diet in adulthood in rats |
topic | Research Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3424467/ https://www.ncbi.nlm.nih.gov/pubmed/22773756 http://dx.doi.org/10.1242/dmm.009043 |
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