CRL4–DDB1–VPRBP ubiquitin ligase mediates the stress triggered proteolysis of Mcm10

When mammalian cells experience radiation insult, DNA replication is stalled to prevent erroneous DNA synthesis. UV-irradiation triggers proteolysis of Mcm10, an essential human replication factor, inhibiting the ongoing replication. Here, we report that Mcm10 associates with E3 ubiquitin ligase com...

Descripción completa

Detalles Bibliográficos
Autores principales: Kaur, Manpreet, Khan, Md. Muntaz, Kar, Ananya, Sharma, Aparna, Saxena, Sandeep
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3424545/
https://www.ncbi.nlm.nih.gov/pubmed/22570418
http://dx.doi.org/10.1093/nar/gks366

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3424545/
https://www.ncbi.nlm.nih.gov/pubmed/22570418
http://dx.doi.org/10.1093/nar/gks366

Ejemplares similares