Characterization and prediction of the binding site in DNA-binding proteins: improvement of accuracy by combining residue composition, evolutionary conservation and structural parameters

We present a set of four parameters that in combination can predict DNA-binding residues on protein structures to a high degree of accuracy. These are the number of evolutionary conserved residues (N(cons)) and their spatial clustering (ρ(e)), hydrogen bond donor capability (D(p)) and residue propen...

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Detalles Bibliográficos
Autores principales: Dey, Sucharita, Pal, Arumay, Guharoy, Mainak, Sonavane, Shrihari, Chakrabarti, Pinak
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Computational Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3424558/
https://www.ncbi.nlm.nih.gov/pubmed/22641851
http://dx.doi.org/10.1093/nar/gks405

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3424558/
https://www.ncbi.nlm.nih.gov/pubmed/22641851
http://dx.doi.org/10.1093/nar/gks405

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