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Crystal structure and mechanism of action of the N6-methyladenine-dependent type IIM restriction endonuclease R.DpnI

DNA methylation-dependent restriction enzymes have many applications in genetic engineering and in the analysis of the epigenetic state of eukaryotic genomes. Nevertheless, high-resolution structures have not yet been reported, and therefore mechanisms of DNA methylation-dependent cleavage are not u...

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Detalles Bibliográficos
Autores principales:	Siwek, Wojciech, Czapinska, Honorata, Bochtler, Matthias, Bujnicki, Janusz M., Skowronek, Krzysztof
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2012
Materias:	Structural Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3424567/ https://www.ncbi.nlm.nih.gov/pubmed/22610857 http://dx.doi.org/10.1093/nar/gks428

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