Cargando…
Mechanistic Study on the Antidepressant-Like Effect of Danggui-Shaoyao-San, a Chinese Herbal Formula
Danggui-Shaoyao-San (DSS), a famous Chinese herbal formula, has been widely used in the treatment of various diseases. Previous studies have shown that DSS produces antidepressant-like effect in rodents. This study aims to investigate the mechanism(s) underlying the antidepressant-like action of DDS...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3424597/ https://www.ncbi.nlm.nih.gov/pubmed/22924052 http://dx.doi.org/10.1155/2012/173565 |
_version_ | 1782241237389017088 |
---|---|
author | Huang, Zhen Mao, Qing-Qiu Zhong, Xiao-Ming Li, Zhao-Yi Qiu, Feng-Mei Ip, Siu-Po |
author_facet | Huang, Zhen Mao, Qing-Qiu Zhong, Xiao-Ming Li, Zhao-Yi Qiu, Feng-Mei Ip, Siu-Po |
author_sort | Huang, Zhen |
collection | PubMed |
description | Danggui-Shaoyao-San (DSS), a famous Chinese herbal formula, has been widely used in the treatment of various diseases. Previous studies have shown that DSS produces antidepressant-like effect in rodents. This study aims to investigate the mechanism(s) underlying the antidepressant-like action of DDS. The results showed that DSS treatment significantly antagonized reserpine-induced ptosis in mice. In addition, DSS treatment significantly increased sucrose consumption in chronic unpredictable stress- (CUS-) treated mice. DSS treatment also markedly attenuated CUS-induced decreases in noradrenaline and dopamine concentrations in mouse brain. Furthermore, DSS treatment significantly reversed CUS-induced increase in serum malondialdehyde (MDA) content and decrease in serum superoxide dismutase (SOD) activity in mice. The results suggest that the antidepressant-like activity of DSS is probably mediated by the modulation of central monoamine neurotransmitter systems and the reduction of oxidative stress. |
format | Online Article Text |
id | pubmed-3424597 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-34245972012-08-24 Mechanistic Study on the Antidepressant-Like Effect of Danggui-Shaoyao-San, a Chinese Herbal Formula Huang, Zhen Mao, Qing-Qiu Zhong, Xiao-Ming Li, Zhao-Yi Qiu, Feng-Mei Ip, Siu-Po Evid Based Complement Alternat Med Research Article Danggui-Shaoyao-San (DSS), a famous Chinese herbal formula, has been widely used in the treatment of various diseases. Previous studies have shown that DSS produces antidepressant-like effect in rodents. This study aims to investigate the mechanism(s) underlying the antidepressant-like action of DDS. The results showed that DSS treatment significantly antagonized reserpine-induced ptosis in mice. In addition, DSS treatment significantly increased sucrose consumption in chronic unpredictable stress- (CUS-) treated mice. DSS treatment also markedly attenuated CUS-induced decreases in noradrenaline and dopamine concentrations in mouse brain. Furthermore, DSS treatment significantly reversed CUS-induced increase in serum malondialdehyde (MDA) content and decrease in serum superoxide dismutase (SOD) activity in mice. The results suggest that the antidepressant-like activity of DSS is probably mediated by the modulation of central monoamine neurotransmitter systems and the reduction of oxidative stress. Hindawi Publishing Corporation 2012 2012-08-09 /pmc/articles/PMC3424597/ /pubmed/22924052 http://dx.doi.org/10.1155/2012/173565 Text en Copyright © 2012 Zhen Huang et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Huang, Zhen Mao, Qing-Qiu Zhong, Xiao-Ming Li, Zhao-Yi Qiu, Feng-Mei Ip, Siu-Po Mechanistic Study on the Antidepressant-Like Effect of Danggui-Shaoyao-San, a Chinese Herbal Formula |
title | Mechanistic Study on the Antidepressant-Like Effect of Danggui-Shaoyao-San, a Chinese Herbal Formula |
title_full | Mechanistic Study on the Antidepressant-Like Effect of Danggui-Shaoyao-San, a Chinese Herbal Formula |
title_fullStr | Mechanistic Study on the Antidepressant-Like Effect of Danggui-Shaoyao-San, a Chinese Herbal Formula |
title_full_unstemmed | Mechanistic Study on the Antidepressant-Like Effect of Danggui-Shaoyao-San, a Chinese Herbal Formula |
title_short | Mechanistic Study on the Antidepressant-Like Effect of Danggui-Shaoyao-San, a Chinese Herbal Formula |
title_sort | mechanistic study on the antidepressant-like effect of danggui-shaoyao-san, a chinese herbal formula |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3424597/ https://www.ncbi.nlm.nih.gov/pubmed/22924052 http://dx.doi.org/10.1155/2012/173565 |
work_keys_str_mv | AT huangzhen mechanisticstudyontheantidepressantlikeeffectofdangguishaoyaosanachineseherbalformula AT maoqingqiu mechanisticstudyontheantidepressantlikeeffectofdangguishaoyaosanachineseherbalformula AT zhongxiaoming mechanisticstudyontheantidepressantlikeeffectofdangguishaoyaosanachineseherbalformula AT lizhaoyi mechanisticstudyontheantidepressantlikeeffectofdangguishaoyaosanachineseherbalformula AT qiufengmei mechanisticstudyontheantidepressantlikeeffectofdangguishaoyaosanachineseherbalformula AT ipsiupo mechanisticstudyontheantidepressantlikeeffectofdangguishaoyaosanachineseherbalformula |