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Improved Metabolic Control in Diabetes, HSP60, and Proinflammatory Mediators
The diabetes-atherosclerosis relationship remains to be fully defined. Repeated prolonged hyperglycemia, increased ROS production and endothelial dysfunction are important factors. One theory is that increased blood levels of heat shock protein (HSP)60 are proinflammatory, through activation of inna...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3424633/ https://www.ncbi.nlm.nih.gov/pubmed/22924123 http://dx.doi.org/10.1155/2012/346501 |
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author | Blasi, Claudio Kim, Eunjung Knowlton, Anne A. |
author_facet | Blasi, Claudio Kim, Eunjung Knowlton, Anne A. |
author_sort | Blasi, Claudio |
collection | PubMed |
description | The diabetes-atherosclerosis relationship remains to be fully defined. Repeated prolonged hyperglycemia, increased ROS production and endothelial dysfunction are important factors. One theory is that increased blood levels of heat shock protein (HSP)60 are proinflammatory, through activation of innate immunity, and contribute to the progression of vascular disease. It was hypothesized that improvement of diabetes control in patients presenting with metabolic syndrome would lower HSP60, and anti-HSP60 antibody levels and decrease inflammatory markers. Paired sera of 17 Italian patients, before and after intensive treatment, were assayed for cytokines, HSP60 and anti-HSP60 antibodies. As expected, intensive treatment was associated with a decrease in HgbA1C (P < 0.001) and BMI (P < 0.001). After treatment, there was a significant decrease in IL-6 (P < 0.05). HSP60 levels were before treatment −6.9 + 1.9, after treatment −7.1 + 2.0 ng/mL (P = ns). Overall HSP60 concentrations were lower than published reports. Anti-HSP60 antibody titers were high and did not decrease with treatment. In conclusion, improvement of diabetic control did not alter HSP60 concentrations or antiHSP60 antibody titers, but led to a reduction of IL-6 levels. |
format | Online Article Text |
id | pubmed-3424633 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-34246332012-08-24 Improved Metabolic Control in Diabetes, HSP60, and Proinflammatory Mediators Blasi, Claudio Kim, Eunjung Knowlton, Anne A. Autoimmune Dis Clinical Study The diabetes-atherosclerosis relationship remains to be fully defined. Repeated prolonged hyperglycemia, increased ROS production and endothelial dysfunction are important factors. One theory is that increased blood levels of heat shock protein (HSP)60 are proinflammatory, through activation of innate immunity, and contribute to the progression of vascular disease. It was hypothesized that improvement of diabetes control in patients presenting with metabolic syndrome would lower HSP60, and anti-HSP60 antibody levels and decrease inflammatory markers. Paired sera of 17 Italian patients, before and after intensive treatment, were assayed for cytokines, HSP60 and anti-HSP60 antibodies. As expected, intensive treatment was associated with a decrease in HgbA1C (P < 0.001) and BMI (P < 0.001). After treatment, there was a significant decrease in IL-6 (P < 0.05). HSP60 levels were before treatment −6.9 + 1.9, after treatment −7.1 + 2.0 ng/mL (P = ns). Overall HSP60 concentrations were lower than published reports. Anti-HSP60 antibody titers were high and did not decrease with treatment. In conclusion, improvement of diabetic control did not alter HSP60 concentrations or antiHSP60 antibody titers, but led to a reduction of IL-6 levels. Hindawi Publishing Corporation 2012 2012-08-12 /pmc/articles/PMC3424633/ /pubmed/22924123 http://dx.doi.org/10.1155/2012/346501 Text en Copyright © 2012 Claudio Blasi et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical Study Blasi, Claudio Kim, Eunjung Knowlton, Anne A. Improved Metabolic Control in Diabetes, HSP60, and Proinflammatory Mediators |
title | Improved Metabolic Control in Diabetes, HSP60, and Proinflammatory Mediators |
title_full | Improved Metabolic Control in Diabetes, HSP60, and Proinflammatory Mediators |
title_fullStr | Improved Metabolic Control in Diabetes, HSP60, and Proinflammatory Mediators |
title_full_unstemmed | Improved Metabolic Control in Diabetes, HSP60, and Proinflammatory Mediators |
title_short | Improved Metabolic Control in Diabetes, HSP60, and Proinflammatory Mediators |
title_sort | improved metabolic control in diabetes, hsp60, and proinflammatory mediators |
topic | Clinical Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3424633/ https://www.ncbi.nlm.nih.gov/pubmed/22924123 http://dx.doi.org/10.1155/2012/346501 |
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