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Improved Metabolic Control in Diabetes, HSP60, and Proinflammatory Mediators

The diabetes-atherosclerosis relationship remains to be fully defined. Repeated prolonged hyperglycemia, increased ROS production and endothelial dysfunction are important factors. One theory is that increased blood levels of heat shock protein (HSP)60 are proinflammatory, through activation of inna...

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Detalles Bibliográficos
Autores principales: Blasi, Claudio, Kim, Eunjung, Knowlton, Anne A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3424633/
https://www.ncbi.nlm.nih.gov/pubmed/22924123
http://dx.doi.org/10.1155/2012/346501
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author Blasi, Claudio
Kim, Eunjung
Knowlton, Anne A.
author_facet Blasi, Claudio
Kim, Eunjung
Knowlton, Anne A.
author_sort Blasi, Claudio
collection PubMed
description The diabetes-atherosclerosis relationship remains to be fully defined. Repeated prolonged hyperglycemia, increased ROS production and endothelial dysfunction are important factors. One theory is that increased blood levels of heat shock protein (HSP)60 are proinflammatory, through activation of innate immunity, and contribute to the progression of vascular disease. It was hypothesized that improvement of diabetes control in patients presenting with metabolic syndrome would lower HSP60, and anti-HSP60 antibody levels and decrease inflammatory markers. Paired sera of 17 Italian patients, before and after intensive treatment, were assayed for cytokines, HSP60 and anti-HSP60 antibodies. As expected, intensive treatment was associated with a decrease in HgbA1C (P < 0.001) and BMI (P < 0.001). After treatment, there was a significant decrease in IL-6 (P < 0.05). HSP60 levels were before treatment −6.9 + 1.9, after treatment −7.1 + 2.0 ng/mL (P = ns). Overall HSP60 concentrations were lower than published reports. Anti-HSP60 antibody titers were high and did not decrease with treatment. In conclusion, improvement of diabetic control did not alter HSP60 concentrations or antiHSP60 antibody titers, but led to a reduction of IL-6 levels.
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spelling pubmed-34246332012-08-24 Improved Metabolic Control in Diabetes, HSP60, and Proinflammatory Mediators Blasi, Claudio Kim, Eunjung Knowlton, Anne A. Autoimmune Dis Clinical Study The diabetes-atherosclerosis relationship remains to be fully defined. Repeated prolonged hyperglycemia, increased ROS production and endothelial dysfunction are important factors. One theory is that increased blood levels of heat shock protein (HSP)60 are proinflammatory, through activation of innate immunity, and contribute to the progression of vascular disease. It was hypothesized that improvement of diabetes control in patients presenting with metabolic syndrome would lower HSP60, and anti-HSP60 antibody levels and decrease inflammatory markers. Paired sera of 17 Italian patients, before and after intensive treatment, were assayed for cytokines, HSP60 and anti-HSP60 antibodies. As expected, intensive treatment was associated with a decrease in HgbA1C (P < 0.001) and BMI (P < 0.001). After treatment, there was a significant decrease in IL-6 (P < 0.05). HSP60 levels were before treatment −6.9 + 1.9, after treatment −7.1 + 2.0 ng/mL (P = ns). Overall HSP60 concentrations were lower than published reports. Anti-HSP60 antibody titers were high and did not decrease with treatment. In conclusion, improvement of diabetic control did not alter HSP60 concentrations or antiHSP60 antibody titers, but led to a reduction of IL-6 levels. Hindawi Publishing Corporation 2012 2012-08-12 /pmc/articles/PMC3424633/ /pubmed/22924123 http://dx.doi.org/10.1155/2012/346501 Text en Copyright © 2012 Claudio Blasi et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Blasi, Claudio
Kim, Eunjung
Knowlton, Anne A.
Improved Metabolic Control in Diabetes, HSP60, and Proinflammatory Mediators
title Improved Metabolic Control in Diabetes, HSP60, and Proinflammatory Mediators
title_full Improved Metabolic Control in Diabetes, HSP60, and Proinflammatory Mediators
title_fullStr Improved Metabolic Control in Diabetes, HSP60, and Proinflammatory Mediators
title_full_unstemmed Improved Metabolic Control in Diabetes, HSP60, and Proinflammatory Mediators
title_short Improved Metabolic Control in Diabetes, HSP60, and Proinflammatory Mediators
title_sort improved metabolic control in diabetes, hsp60, and proinflammatory mediators
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3424633/
https://www.ncbi.nlm.nih.gov/pubmed/22924123
http://dx.doi.org/10.1155/2012/346501
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