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Role of p16(INK4A) in Replicative Senescence and DNA Damage-Induced Premature Senescence in p53-Deficient Human Cells

The p16(INK4A) (hereafter p16) tumor suppressor is encoded by the INK4A/ARF locus which is among the most commonly dysregulated sequences in human cancer. By inhibiting cyclin-dependent kinases, p16 activates the G1-S checkpoint, and this response is often considered to be critical for establishing...

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Detalles Bibliográficos
Autores principales:	Mirzayans, Razmik, Andrais, Bonnie, Hansen, Gavin, Murray, David
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2012
Materias:	Review Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3424640/ https://www.ncbi.nlm.nih.gov/pubmed/22924132 http://dx.doi.org/10.1155/2012/951574

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