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Longitudinal Associations Between Changes in Physical Activity and Onset of Type 2 Diabetes in Older British Men: The influence of adiposity

OBJECTIVE: To determine how much physical activity (PA) is needed to protect against diabetes onset in older adults, whether protection is greater among overweight individuals, and whether taking up moderate activity in later life is beneficial. RESEARCH DESIGN AND METHODS: Men (4,252) from a U.K. p...

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Autores principales: Jefferis, Barbara J., Whincup, Peter H., Lennon, Lucy, Wannamethee, S. Goya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3424991/
https://www.ncbi.nlm.nih.gov/pubmed/22751959
http://dx.doi.org/10.2337/dc11-2280
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author Jefferis, Barbara J.
Whincup, Peter H.
Lennon, Lucy
Wannamethee, S. Goya
author_facet Jefferis, Barbara J.
Whincup, Peter H.
Lennon, Lucy
Wannamethee, S. Goya
author_sort Jefferis, Barbara J.
collection PubMed
description OBJECTIVE: To determine how much physical activity (PA) is needed to protect against diabetes onset in older adults, whether protection is greater among overweight individuals, and whether taking up moderate activity in later life is beneficial. RESEARCH DESIGN AND METHODS: Men (4,252) from a U.K. population-based cohort self-reported usual PA (regular walking and cycling, recreational activity, and sport) in 1996 and in 1998–2000, alongside other health behaviors and medical history. Fasting blood lipids were measured. Median follow-up was 7.1 years, during which 135 cases of type 2 diabetes (validated self-report) occurred. RESULTS: Among 3,012 men free from cardiovascular disease and diabetes in 1998–2000, 9% reported no usual leisure-time PA, 23% occasional PA, and 15% vigorous PA. Compared with men reporting no activity, men reporting occasional, light, moderate, moderately vigorous, and vigorous PA had lower diabetes risks: hazard ratio (HR) 0.58 (95% CI 0.33–1.02), 0.39 (0.20–0.74), 0.38 (0.19–0.73), 0.39 (0.20–0.77), and 0.33 (0.16–0.70), respectively; P (trend) = 0.002, adjusted for age, social class, tobacco, alcohol, diet, and blood lipids. Adjustment for BMI, waist circumference, or fasting insulin attenuated HRs. HRs were stronger in men with BMI ≥28 vs. <28 kg/m(2) (interaction P = 0.02). Compared with men reporting light activity or less in 1996 and 2000, men who became at least moderately active by 2000 or remained at least moderately active at both times had adjusted HRs of 0.62 (0.34–1.12) and 0.51 (0.31–0.82), respectively. CONCLUSIONS: Even light PA markedly reduced diabetes risk in older men, especially among the overweight or obese. Taking up or maintaining at least moderate PA in older adulthood strongly protected against diabetes.
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spelling pubmed-34249912013-09-01 Longitudinal Associations Between Changes in Physical Activity and Onset of Type 2 Diabetes in Older British Men: The influence of adiposity Jefferis, Barbara J. Whincup, Peter H. Lennon, Lucy Wannamethee, S. Goya Diabetes Care Original Research OBJECTIVE: To determine how much physical activity (PA) is needed to protect against diabetes onset in older adults, whether protection is greater among overweight individuals, and whether taking up moderate activity in later life is beneficial. RESEARCH DESIGN AND METHODS: Men (4,252) from a U.K. population-based cohort self-reported usual PA (regular walking and cycling, recreational activity, and sport) in 1996 and in 1998–2000, alongside other health behaviors and medical history. Fasting blood lipids were measured. Median follow-up was 7.1 years, during which 135 cases of type 2 diabetes (validated self-report) occurred. RESULTS: Among 3,012 men free from cardiovascular disease and diabetes in 1998–2000, 9% reported no usual leisure-time PA, 23% occasional PA, and 15% vigorous PA. Compared with men reporting no activity, men reporting occasional, light, moderate, moderately vigorous, and vigorous PA had lower diabetes risks: hazard ratio (HR) 0.58 (95% CI 0.33–1.02), 0.39 (0.20–0.74), 0.38 (0.19–0.73), 0.39 (0.20–0.77), and 0.33 (0.16–0.70), respectively; P (trend) = 0.002, adjusted for age, social class, tobacco, alcohol, diet, and blood lipids. Adjustment for BMI, waist circumference, or fasting insulin attenuated HRs. HRs were stronger in men with BMI ≥28 vs. <28 kg/m(2) (interaction P = 0.02). Compared with men reporting light activity or less in 1996 and 2000, men who became at least moderately active by 2000 or remained at least moderately active at both times had adjusted HRs of 0.62 (0.34–1.12) and 0.51 (0.31–0.82), respectively. CONCLUSIONS: Even light PA markedly reduced diabetes risk in older men, especially among the overweight or obese. Taking up or maintaining at least moderate PA in older adulthood strongly protected against diabetes. American Diabetes Association 2012-09 2012-08-14 /pmc/articles/PMC3424991/ /pubmed/22751959 http://dx.doi.org/10.2337/dc11-2280 Text en © 2012 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.
spellingShingle Original Research
Jefferis, Barbara J.
Whincup, Peter H.
Lennon, Lucy
Wannamethee, S. Goya
Longitudinal Associations Between Changes in Physical Activity and Onset of Type 2 Diabetes in Older British Men: The influence of adiposity
title Longitudinal Associations Between Changes in Physical Activity and Onset of Type 2 Diabetes in Older British Men: The influence of adiposity
title_full Longitudinal Associations Between Changes in Physical Activity and Onset of Type 2 Diabetes in Older British Men: The influence of adiposity
title_fullStr Longitudinal Associations Between Changes in Physical Activity and Onset of Type 2 Diabetes in Older British Men: The influence of adiposity
title_full_unstemmed Longitudinal Associations Between Changes in Physical Activity and Onset of Type 2 Diabetes in Older British Men: The influence of adiposity
title_short Longitudinal Associations Between Changes in Physical Activity and Onset of Type 2 Diabetes in Older British Men: The influence of adiposity
title_sort longitudinal associations between changes in physical activity and onset of type 2 diabetes in older british men: the influence of adiposity
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3424991/
https://www.ncbi.nlm.nih.gov/pubmed/22751959
http://dx.doi.org/10.2337/dc11-2280
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