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Diabetes and Cause-Specific Mortality in a Prospective Cohort of One Million U.S. Adults
OBJECTIVE: Diabetes is a major predictor of death from heart disease and stroke; its impact on nonvascular mortality, including specific cancers, is less understood. We examined the association of diabetes with cause-specific mortality, including deaths from specific cancers. RESEARCH DESIGN AND MET...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Diabetes Association
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3425000/ https://www.ncbi.nlm.nih.gov/pubmed/22699290 http://dx.doi.org/10.2337/dc12-0002 |
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author | Campbell, Peter T. Newton, Christina C. Patel, Alpa V. Jacobs, Eric J. Gapstur, Susan M. |
author_facet | Campbell, Peter T. Newton, Christina C. Patel, Alpa V. Jacobs, Eric J. Gapstur, Susan M. |
author_sort | Campbell, Peter T. |
collection | PubMed |
description | OBJECTIVE: Diabetes is a major predictor of death from heart disease and stroke; its impact on nonvascular mortality, including specific cancers, is less understood. We examined the association of diabetes with cause-specific mortality, including deaths from specific cancers. RESEARCH DESIGN AND METHODS: A prospective cohort of 1,053,831 U.S. adults, without cancer at baseline, enrolled in the Cancer Prevention Study-II in 1982 and was followed for mortality until December 2008. At baseline, participants completed a self-administered questionnaire that included information on diabetes, smoking, physical activity, height, and weight. Multivariable-adjusted relative risks (RRs) (95% CI) were estimated using Cox proportional hazards regression. RESULTS: During 26 years of follow-up, 243,051 men and 222,109 women died. In multivariable models that controlled for age, BMI, and other variables, diabetes was associated with higher risk of all-cause mortality (women RR 1.90 [95% CI 1.87–1.93]; men 1.73 [1.70–1.75]). Among women, diabetes was associated with higher risk of death from cancers of the liver (1.40 [1.05–1.86]), pancreas (1.31 [1.14–1.51]), endometrium (1.33 [1.08–1.65]), colon (1.18 [1.04–1.33]), and breast (1.16 [1.03–1.29]). Among men, diabetes was associated with risk of death from cancers of the breast (4.20 [2.20–8.04]), liver (2.26 [1.89–2.70]), oral cavity and pharynx (1.44 [1.07–1.94]), pancreas (1.40 [1.23–1.59]), bladder (1.22 [1.01–1.47]), colon (1.15 [1.03–1.29]), and (inversely) prostate (0.88 [0.79–0.97]). Diabetes was also associated with higher risks of death involving the circulatory system, respiratory system, digestive system, genitourinary system, and external causes/accidental deaths. CONCLUSIONS: Diabetes is associated with higher risk of death for many diseases, including several specific forms of cancer. |
format | Online Article Text |
id | pubmed-3425000 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | American Diabetes Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-34250002013-09-01 Diabetes and Cause-Specific Mortality in a Prospective Cohort of One Million U.S. Adults Campbell, Peter T. Newton, Christina C. Patel, Alpa V. Jacobs, Eric J. Gapstur, Susan M. Diabetes Care Original Research OBJECTIVE: Diabetes is a major predictor of death from heart disease and stroke; its impact on nonvascular mortality, including specific cancers, is less understood. We examined the association of diabetes with cause-specific mortality, including deaths from specific cancers. RESEARCH DESIGN AND METHODS: A prospective cohort of 1,053,831 U.S. adults, without cancer at baseline, enrolled in the Cancer Prevention Study-II in 1982 and was followed for mortality until December 2008. At baseline, participants completed a self-administered questionnaire that included information on diabetes, smoking, physical activity, height, and weight. Multivariable-adjusted relative risks (RRs) (95% CI) were estimated using Cox proportional hazards regression. RESULTS: During 26 years of follow-up, 243,051 men and 222,109 women died. In multivariable models that controlled for age, BMI, and other variables, diabetes was associated with higher risk of all-cause mortality (women RR 1.90 [95% CI 1.87–1.93]; men 1.73 [1.70–1.75]). Among women, diabetes was associated with higher risk of death from cancers of the liver (1.40 [1.05–1.86]), pancreas (1.31 [1.14–1.51]), endometrium (1.33 [1.08–1.65]), colon (1.18 [1.04–1.33]), and breast (1.16 [1.03–1.29]). Among men, diabetes was associated with risk of death from cancers of the breast (4.20 [2.20–8.04]), liver (2.26 [1.89–2.70]), oral cavity and pharynx (1.44 [1.07–1.94]), pancreas (1.40 [1.23–1.59]), bladder (1.22 [1.01–1.47]), colon (1.15 [1.03–1.29]), and (inversely) prostate (0.88 [0.79–0.97]). Diabetes was also associated with higher risks of death involving the circulatory system, respiratory system, digestive system, genitourinary system, and external causes/accidental deaths. CONCLUSIONS: Diabetes is associated with higher risk of death for many diseases, including several specific forms of cancer. American Diabetes Association 2012-09 2012-08-14 /pmc/articles/PMC3425000/ /pubmed/22699290 http://dx.doi.org/10.2337/dc12-0002 Text en © 2012 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details. |
spellingShingle | Original Research Campbell, Peter T. Newton, Christina C. Patel, Alpa V. Jacobs, Eric J. Gapstur, Susan M. Diabetes and Cause-Specific Mortality in a Prospective Cohort of One Million U.S. Adults |
title | Diabetes and Cause-Specific Mortality in a Prospective Cohort of One Million U.S. Adults |
title_full | Diabetes and Cause-Specific Mortality in a Prospective Cohort of One Million U.S. Adults |
title_fullStr | Diabetes and Cause-Specific Mortality in a Prospective Cohort of One Million U.S. Adults |
title_full_unstemmed | Diabetes and Cause-Specific Mortality in a Prospective Cohort of One Million U.S. Adults |
title_short | Diabetes and Cause-Specific Mortality in a Prospective Cohort of One Million U.S. Adults |
title_sort | diabetes and cause-specific mortality in a prospective cohort of one million u.s. adults |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3425000/ https://www.ncbi.nlm.nih.gov/pubmed/22699290 http://dx.doi.org/10.2337/dc12-0002 |
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