Cargando…

Phase I/IIa study of intratumoral/intracerebral or intravenous/intracerebral administration of Parvovirus H-1 (ParvOryx) in patients with progressive primary or recurrent glioblastoma multiforme: ParvOryx01 protocol

BACKGROUND: The treatment of patients with malignant brain tumors remains a major oncological problem. The median survival of patients with glioblastoma multiforme (GBM), the most malignant type, is only 15 months after initial diagnosis and even less after tumor recurrence. Improvements of standard...

Descripción completa

Detalles Bibliográficos
Autores principales:	Geletneky, Karsten, Huesing, Johannes, Rommelaere, Jean, Schlehofer, Joerg R, Leuchs, Barbara, Dahm, Michael, Krebs, Ottheinz, von Knebel Doeberitz, Magnus, Huber, Bernard, Hajda, Jacek
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Study Protocol
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3425127/ https://www.ncbi.nlm.nih.gov/pubmed/22436661 http://dx.doi.org/10.1186/1471-2407-12-99

Ejemplares similares

A non-controlled, single arm, open label, phase II study of intravenous and intratumoral administration of ParvOryx in patients with metastatic, inoperable pancreatic cancer: ParvOryx02 protocol
por: Hajda, Jacek, et al.
Publicado: (2017)

Parvoviruses PARV4 and PARV5 and Hepatitis C Virus
por: Fryer, Jacqueline F., et al.
Publicado: (2007)

Parenteral Transmission of the Novel Human Parvovirus PARV4
por: Simmonds, Peter, et al.
Publicado: (2007)

Paratuberculosis in Captive Scimitar-Horned Oryxes (Oryx dammah)
por: Pigoli, Claudio, et al.
Publicado: (2020)

Uterine metastatic rhabdomyosarcoma in a scimitar-horned oryx (Oryx dammah)
por: GO, Du-Min, et al.
Publicado: (2018)

PARV4: An Emerging Tetraparvovirus
por: Matthews, Philippa C., et al.
Publicado: (2014)

Hematology and serum biochemistry variables in apparently normal Arabian Oryx (Oryx leucoryx)
por: Eljarah, Abdulhakeem, et al.
Publicado: (2023)

The Oryx Antelope (Oryx gazella): An Unexpected Host for Porcine Circovirus-2 (PCV-2)
por: Molini, Umberto, et al.
Publicado: (2021)

Paediatric PARV4 infection in South Africa: relationship to age, maternal PARV4 status, and HIV infection
por: Matthews, Philippa, et al.
Publicado: (2014)

Human parvovirus 4 ‘PARV4’ remains elusive despite a decade of study
por: Matthews, Philippa C., et al.
Publicado: (2017)

PARVing the Way to Cap Translation for Seizure Control
por: Gross, Christina
Publicado: (2021)

Fecal parasite identification by microscopy and PCR in scimitar-horned oryx, Oryx dammah, managed at two sites
por: Pauling, Cassandra Dawn, et al.
Publicado: (2016)

Short-term effects of GPS collars on the activity, behavior, and adrenal response of scimitar-horned oryx (Oryx dammah)
por: Stabach, Jared A., et al.
Publicado: (2020)

Experience and social factors influence movement and habitat selection in scimitar-horned oryx (Oryx dammah) reintroduced into Chad
por: Majaliwa, M. M., et al.
Publicado: (2022)

Identification, Isolation, and Molecular Characterization of Betacoronavirus in Oryx leucoryx
por: David, Dan, et al.
Publicado: (2023)

Human parvovirus PARV4 DNA in tissues from adult individuals: a comparison with human parvovirus B19 (B19V)
por: Corcioli, Fabiana, et al.
Publicado: (2010)

High Frequency, Sustained T Cell Responses to PARV4 Suggest Viral Persistence In Vivo
por: Simmons, Ruth, et al.
Publicado: (2011)

Oncolytic H-1 Parvovirus Shows Safety and Signs of Immunogenic Activity in a First Phase I/IIa Glioblastoma Trial
por: Geletneky, Karsten, et al.
Publicado: (2017)

Conservation management strategy impacts inbreeding and mutation load in scimitar-horned oryx
por: Humble, Emily, et al.
Publicado: (2023)

Prevalence of Human Parvovirus B19, Bocavirus, and PARV4 in Blood Samples from the General Population of China and Lack of a Correlation between Parvovirus and Hepatitis B Co-Infection
por: Tong, Rui, et al.
Publicado: (2013)

Providing baseline data for conservation–Heart rate monitoring in captive scimitar-horned oryx
por: Leimgruber, Peter, et al.
Publicado: (2023)

PARV4 prevalence, phylogeny, immunology and coinfection with HIV, HBV and HCV in a multicentre African cohort
por: Sharp, Colin P., et al.
Publicado: (2017)

Living on the edge: Daily, seasonal and annual body temperature patterns of Arabian oryx in Saudi Arabia
por: Streicher, S., et al.
Publicado: (2017)

Rescued back from extinction in the wild: past, present and future of the genetics of the Arabian oryx in Oman
por: Al Rawahi, Qais, et al.
Publicado: (2022)

Carcass and Offal Yields of Farmed Common Eland (Taurotragus oryx) Males, as Affected by Age and Immunocastration
por: Needham, Tersia, et al.
Publicado: (2022)

Improved Killing of Human High-Grade Glioma Cells by Combining Ionizing Radiation with Oncolytic Parvovirus H-1 Infection
por: Geletneky, Karsten, et al.
Publicado: (2010)

A near-chromosome-scale genome assembly of the gemsbok (Oryx gazella): an iconic antelope of the Kalahari desert
por: Farré, Marta, et al.
Publicado: (2019)

Interspecific Nuclear Transfer Blastocysts Reconstructed from Arabian Oryx Somatic Cells and Domestic Cow Ooplasm
por: Ammari, Aiman A., et al.
Publicado: (2022)

Orbivirus Screening from Imported Captive Oryx in the United Arab Emirates Stresses the Importance of Pre-Import and Transit Measures
por: Martinelle, Ludovic, et al.
Publicado: (2022)

BOVIDS: A deep learning‐based software package for pose estimation to evaluate nightly behavior and its application to common elands (Tragelaphus oryx) in zoos
por: Gübert, Jennifer, et al.
Publicado: (2022)

Preclinical Testing of an Oncolytic Parvovirus: Standard Protoparvovirus H-1PV Efficiently Induces Osteosarcoma Cell Lysis In Vitro
por: Geiss, Carsten, et al.
Publicado: (2017)

Tumor Selectivity of Oncolytic Parvoviruses: From in vitro and Animal Models to Cancer Patients
por: Angelova, Assia L., et al.
Publicado: (2015)

Immunotherapeutic Potential of Oncolytic H-1 Parvovirus: Hints of Glioblastoma Microenvironment Conversion towards Immunogenicity
por: Angelova, Assia L., et al.
Publicado: (2017)

Oncolytic effects of parvovirus H-1 in medulloblastoma are associated with repression of master regulators of early neurogenesis
por: Lacroix, Jeannine, et al.
Publicado: (2014)

Pediatric and Adult High-Grade Glioma Stem Cell Culture Models Are Permissive to Lytic Infection with Parvovirus H-1
por: Josupeit, Rafael, et al.
Publicado: (2016)

Preclinical Testing of an Oncolytic Parvovirus in Ewing Sarcoma: Protoparvovirus H-1 Induces Apoptosis and Lytic Infection In Vitro but Fails to Improve Survival In Vivo
por: Lacroix, Jeannine, et al.
Publicado: (2018)

A novel scalable, robust downstream process for oncolytic rat parvovirus: isoelectric point-based elimination of empty particles
por: Leuchs, Barbara, et al.
Publicado: (2017)

Activation of the human immune system by chemotherapeutic or targeted agents combined with the oncolytic parvovirus H-1
por: Moehler, Markus, et al.
Publicado: (2011)

Management of intracerebral hemorrhage
por: Sahni, Ramandeep, et al.
Publicado: (2007)

Intracerebral Injection of Antivenine
por: Atal, P.
Publicado: (1900)

Cannot write session to /tmp/vufind_sessions/sess_h3bbj797b0gdaq3m6bego46fm6