Cargando…

Modulations of neural activity in auditory streaming caused by spectral and temporal alternation in subsequent stimuli: a magnetoencephalographic study

BACKGROUND: The aim of the present study was to identify a specific neuronal correlate underlying the pre-attentive auditory stream segregation of subsequent sound patterns alternating in spectral or temporal cues. Fifteen participants with normal hearing were presented with series’ of two consecuti...

Descripción completa

Detalles Bibliográficos
Autores principales: Chakalov, Ivan, Draganova, Rossitza, Wollbrink, Andreas, Preissl, Hubert, Pantev, Christo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3425313/
https://www.ncbi.nlm.nih.gov/pubmed/22716917
http://dx.doi.org/10.1186/1471-2202-13-72
_version_ 1782241362861621248
author Chakalov, Ivan
Draganova, Rossitza
Wollbrink, Andreas
Preissl, Hubert
Pantev, Christo
author_facet Chakalov, Ivan
Draganova, Rossitza
Wollbrink, Andreas
Preissl, Hubert
Pantev, Christo
author_sort Chakalov, Ivan
collection PubMed
description BACKGROUND: The aim of the present study was to identify a specific neuronal correlate underlying the pre-attentive auditory stream segregation of subsequent sound patterns alternating in spectral or temporal cues. Fifteen participants with normal hearing were presented with series’ of two consecutive ABA auditory tone-triplet sequences, the initial triplets being the Adaptation sequence and the subsequent triplets being the Test sequence. In the first experiment, the frequency separation (delta-f) between A and B tones in the sequences was varied by 2, 4 and 10 semitones. In the second experiment, a constant delta-f of 6 semitones was maintained but the Inter-Stimulus Intervals (ISIs) between A and B tones were varied. Auditory evoked magnetic fields (AEFs) were recorded using magnetoencephalography (MEG). Participants watched a muted video of their choice and ignored the auditory stimuli. In a subsequent behavioral study both MEG experiments were replicated to provide information about the participants’ perceptual state. RESULTS: MEG measurements showed a significant increase in the amplitude of the B-tone related P1 component of the AEFs as delta-f increased. This effect was seen predominantly in the left hemisphere. A significant increase in the amplitude of the N1 component was only obtained for a Test sequence delta-f of 10 semitones with a prior Adaptation sequence of 2 semitones. This effect was more pronounced in the right hemisphere. The additional behavioral data indicated an increased probability of two-stream perception for delta-f = 4 and delta-f = 10 semitones with a preceding Adaptation sequence of 2 semitones. However, neither the neural activity nor the perception of the successive streaming sequences were modulated when the ISIs were alternated. CONCLUSIONS: Our MEG experiment demonstrated differences in the behavior of P1 and N1 components during the automatic segregation of sounds when induced by an initial Adaptation sequence. The P1 component appeared enhanced in all Test-conditions and thus demonstrates the preceding context effect, whereas N1 was specifically modulated only by large delta-f Test sequences induced by a preceding small delta-f Adaptation sequence. These results suggest that P1 and N1 components represent at least partially-different systems that underlie the neural representation of auditory streaming.
format Online
Article
Text
id pubmed-3425313
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-34253132012-08-23 Modulations of neural activity in auditory streaming caused by spectral and temporal alternation in subsequent stimuli: a magnetoencephalographic study Chakalov, Ivan Draganova, Rossitza Wollbrink, Andreas Preissl, Hubert Pantev, Christo BMC Neurosci Research Article BACKGROUND: The aim of the present study was to identify a specific neuronal correlate underlying the pre-attentive auditory stream segregation of subsequent sound patterns alternating in spectral or temporal cues. Fifteen participants with normal hearing were presented with series’ of two consecutive ABA auditory tone-triplet sequences, the initial triplets being the Adaptation sequence and the subsequent triplets being the Test sequence. In the first experiment, the frequency separation (delta-f) between A and B tones in the sequences was varied by 2, 4 and 10 semitones. In the second experiment, a constant delta-f of 6 semitones was maintained but the Inter-Stimulus Intervals (ISIs) between A and B tones were varied. Auditory evoked magnetic fields (AEFs) were recorded using magnetoencephalography (MEG). Participants watched a muted video of their choice and ignored the auditory stimuli. In a subsequent behavioral study both MEG experiments were replicated to provide information about the participants’ perceptual state. RESULTS: MEG measurements showed a significant increase in the amplitude of the B-tone related P1 component of the AEFs as delta-f increased. This effect was seen predominantly in the left hemisphere. A significant increase in the amplitude of the N1 component was only obtained for a Test sequence delta-f of 10 semitones with a prior Adaptation sequence of 2 semitones. This effect was more pronounced in the right hemisphere. The additional behavioral data indicated an increased probability of two-stream perception for delta-f = 4 and delta-f = 10 semitones with a preceding Adaptation sequence of 2 semitones. However, neither the neural activity nor the perception of the successive streaming sequences were modulated when the ISIs were alternated. CONCLUSIONS: Our MEG experiment demonstrated differences in the behavior of P1 and N1 components during the automatic segregation of sounds when induced by an initial Adaptation sequence. The P1 component appeared enhanced in all Test-conditions and thus demonstrates the preceding context effect, whereas N1 was specifically modulated only by large delta-f Test sequences induced by a preceding small delta-f Adaptation sequence. These results suggest that P1 and N1 components represent at least partially-different systems that underlie the neural representation of auditory streaming. BioMed Central 2012-06-20 /pmc/articles/PMC3425313/ /pubmed/22716917 http://dx.doi.org/10.1186/1471-2202-13-72 Text en Copyright ©2012 Chakalov et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Chakalov, Ivan
Draganova, Rossitza
Wollbrink, Andreas
Preissl, Hubert
Pantev, Christo
Modulations of neural activity in auditory streaming caused by spectral and temporal alternation in subsequent stimuli: a magnetoencephalographic study
title Modulations of neural activity in auditory streaming caused by spectral and temporal alternation in subsequent stimuli: a magnetoencephalographic study
title_full Modulations of neural activity in auditory streaming caused by spectral and temporal alternation in subsequent stimuli: a magnetoencephalographic study
title_fullStr Modulations of neural activity in auditory streaming caused by spectral and temporal alternation in subsequent stimuli: a magnetoencephalographic study
title_full_unstemmed Modulations of neural activity in auditory streaming caused by spectral and temporal alternation in subsequent stimuli: a magnetoencephalographic study
title_short Modulations of neural activity in auditory streaming caused by spectral and temporal alternation in subsequent stimuli: a magnetoencephalographic study
title_sort modulations of neural activity in auditory streaming caused by spectral and temporal alternation in subsequent stimuli: a magnetoencephalographic study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3425313/
https://www.ncbi.nlm.nih.gov/pubmed/22716917
http://dx.doi.org/10.1186/1471-2202-13-72
work_keys_str_mv AT chakalovivan modulationsofneuralactivityinauditorystreamingcausedbyspectralandtemporalalternationinsubsequentstimuliamagnetoencephalographicstudy
AT draganovarossitza modulationsofneuralactivityinauditorystreamingcausedbyspectralandtemporalalternationinsubsequentstimuliamagnetoencephalographicstudy
AT wollbrinkandreas modulationsofneuralactivityinauditorystreamingcausedbyspectralandtemporalalternationinsubsequentstimuliamagnetoencephalographicstudy
AT preisslhubert modulationsofneuralactivityinauditorystreamingcausedbyspectralandtemporalalternationinsubsequentstimuliamagnetoencephalographicstudy
AT pantevchristo modulationsofneuralactivityinauditorystreamingcausedbyspectralandtemporalalternationinsubsequentstimuliamagnetoencephalographicstudy