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The Gly(972)Arg Variant of Human IRS1 Gene Is Associated With Variation in Glomerular Filtration Rate Likely Through Impaired Insulin Receptor Signaling

The objective of this study is to identify and characterize the genetic variants related to the glomerular filtration rate (GFR) linkage on 2q37. Of the positional candidate genes, we selected IRS1 and resequenced its 2-kb promoter region and exons for sequence variants in 32 subjects. A total of 11...

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Detalles Bibliográficos
Autores principales:	Thameem, Farook, Puppala, Sobha, Schneider, Jennifer, Bhandari, Basant, Arya, Rector, Arar, Nedal H., Vasylyeva, Tetyana L., Farook, Vidya S., Fowler, Sharon, Almasy, Laura, Blangero, John, Duggirala, Ravindranath, Abboud, Hanna E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2012
Materias:	Genetics/Genomes/Proteomics/Metabolomics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3425400/ https://www.ncbi.nlm.nih.gov/pubmed/22617042 http://dx.doi.org/10.2337/db11-1078

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