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Rapamycin/IL-2 Combination Therapy in Patients With Type 1 Diabetes Augments Tregs yet Transiently Impairs β-Cell Function
Rapamycin/interleukin-2 (IL-2) combination treatment of NOD mice effectively treats autoimmune diabetes. We performed a phase 1 clinical trial to test the safety and immunologic effects of rapamycin/IL-2 combination therapy in type 1 diabetic (T1D) patients. Nine T1D subjects were treated with 2–4 m...
Autores principales: | Long, S. Alice, Rieck, Mary, Sanda, Srinath, Bollyky, Jennifer B., Samuels, Peter L., Goland, Robin, Ahmann, Andrew, Rabinovitch, Alex, Aggarwal, Sudeepta, Phippard, Deborah, Turka, Laurence A., Ehlers, Mario R., Bianchine, Peter J., Boyle, Karen D., Adah, Steven A., Bluestone, Jeffrey A., Buckner, Jane H., Greenbaum, Carla J. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Diabetes Association
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3425404/ https://www.ncbi.nlm.nih.gov/pubmed/22721971 http://dx.doi.org/10.2337/db12-0049 |
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