Cargando…

Human β-Cell Proliferation and Intracellular Signaling: Driving in the Dark Without a Road Map

A major goal in diabetes research is to find ways to enhance the mass and function of insulin secreting β-cells in the endocrine pancreas to prevent and/or delay the onset or even reverse overt diabetes. In this Perspectives in Diabetes article, we highlight the contrast between the relatively large...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kulkarni, Rohit N., Mizrachi, Ernesto-Bernal, Ocana, Adolfo Garcia, Stewart, Andrew F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2012
Materias:	Perspectives in Diabetes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3425429/ https://www.ncbi.nlm.nih.gov/pubmed/22751699 http://dx.doi.org/10.2337/db12-0018

Ejemplares similares

Human β-Cell Proliferation and Intracellular Signaling Part 2: Still Driving in the Dark Without a Road Map
por: Bernal-Mizrachi, Ernesto, et al.
Publicado: (2014)

Human β-Cell Proliferation and Intracellular Signaling: Part 3
por: Stewart, Andrew F., et al.
Publicado: (2015)

Using the Past to Inform the Future: Anti-VEGF Therapy as a Road Map to Develop Novel Therapies for Diabetic Retinopathy
por: Titchenell, Paul M., et al.
Publicado: (2013)

Artificial intelligence in medical ultrasonography: driving on an unpaved road
por: Kim, Young H.
Publicado: (2021)

Living Dangerously: Protective and Harmful ER Stress Responses in Pancreatic β-Cells
por: Sharma, Rohit B., et al.
Publicado: (2021)

OR24-4 Targeting Hyperglucagonemia Reverses Glucagon Resistance
por: Bernal-Mizrachi, Ernesto, et al.
Publicado: (2022)

Dilated eye examination screening guideline compliance among patients with diabetes without a diabetic retinopathy diagnosis: the role of geographic access
por: Lee, David J, et al.
Publicado: (2014)

The Road Map for Megakaryopoietic Lineage from Hematopoietic Stem/Progenitor Cells
por: Nishikii, Hidekazu, et al.
Publicado: (2017)

Historical Perspective: Beginnings of the β-Cell: Current Perspectives in β-Cell Development
por: Seymour, Philip A., et al.
Publicado: (2011)

β-Cell MicroRNAs: Small but Powerful
por: Filios, Stephen R., et al.
Publicado: (2015)

Probing β-Cell Biology in Space and Time
por: Arrojo e Drigo, Rafael
Publicado: (2021)

On the road to replication
por: Diffley, John FX
Publicado: (2016)

Rac1 drives intestinal stem cell proliferation and regeneration
por: Myant, Kevin B, et al.
Publicado: (2013)

Lignin biosynthesis: old roads revisited and new roads explored
por: Dixon, Richard A., et al.
Publicado: (2019)

β-Cell Growth and Regeneration: Replication Is Only Part of the Story
por: Bonner-Weir, Susan, et al.
Publicado: (2010)

New Understanding of β-Cell Heterogeneity and In Situ Islet Function
por: Benninger, Richard K.P., et al.
Publicado: (2018)

β-Cell Mass and Type 1 Diabetes: Going, Going, Gone?
por: Akirav, Eitan, et al.
Publicado: (2008)

Immune Recognition of β-Cells: Neoepitopes as Key Players in the Loss of Tolerance
por: James, Eddie A., et al.
Publicado: (2018)

MicroRNAs in β-Cell Biology, Insulin Resistance, Diabetes and Its Complications
por: Fernandez-Valverde, Selene L., et al.
Publicado: (2011)

Direct Autocrine Action of Insulin on β-Cells: Does It Make Physiological Sense?
por: Rhodes, Christopher J., et al.
Publicado: (2013)

Conflicting Views About Interactions Between Pancreatic α-Cells and β-Cells
por: Weir, Gordon C., et al.
Publicado: (2023)

From Pancreatic β-Cell Gene Networks to Novel Therapies for Type 1 Diabetes
por: Eizirik, Decio L., et al.
Publicado: (2021)

How Does Type 1 Diabetes Develop?: The Notion of Homicide or β-Cell Suicide Revisited
por: Atkinson, Mark A., et al.
Publicado: (2011)

Through the Fog: Recent Clinical Trials to Preserve β-Cell Function in Type 1 Diabetes
por: Greenbaum, Carla J., et al.
Publicado: (2012)

Diabetes: Concepts of β-Cell Organ Dysfunction and Failure Would Lead to Earlier Diagnoses and Prevention
por: Charles, M. Arthur, et al.
Publicado: (2021)

Is the Diminished Incretin Effect in Type 2 Diabetes Just an Epi-Phenomenon of Impaired β-Cell Function?
por: Meier, Juris J., et al.
Publicado: (2010)

β-Cell–Specific Gene Repression: A Mechanism to Protect Against Inappropriate or Maladjusted Insulin Secretion?
por: Schuit, Frans, et al.
Publicado: (2012)

β-Cell Failure in Type 2 Diabetes: A Case of Asking Too Much of Too Few?
por: Costes, Safia, et al.
Publicado: (2013)

A Road Map for 21st Century Genetic Restoration: Gene Pool Enrichment of the Black-Footed Ferret
por: Wisely, Samantha M., et al.
Publicado: (2015)

Protein Kinase C Function in Muscle, Liver, and β-Cells and Its Therapeutic Implications for Type 2 Diabetes
por: Schmitz-Peiffer, Carsten, et al.
Publicado: (2008)

Road map for research on responsible artificial intelligence for development (AI4D) in African countries: The case study of agriculture
por: Gwagwa, Arthur, et al.
Publicado: (2021)

Can quality management drive evidence generation?
por: Meeker-O’Connell, Ann, et al.
Publicado: (2021)

Road manslaughter—or just the cost of progress?
por: Mooren, L, et al.
Publicado: (2009)

On the Road to Strain-Resolved Comparative Metagenomics
por: Segata, Nicola
Publicado: (2018)

Evolution of Brains and Computers: The Roads Not Taken
por: Solé, Ricard, et al.
Publicado: (2022)

The “Perfect Storm” for Type 1 Diabetes: The Complex Interplay Between Intestinal Microbiota, Gut Permeability, and Mucosal Immunity
por: Vaarala, Outi, et al.
Publicado: (2008)

Viral Trigger for Type 1 Diabetes: Pros and Cons
por: Filippi, Christophe M., et al.
Publicado: (2008)

Primer: Immunity and Autoimmunity
por: Pietropaolo, Massimo, et al.
Publicado: (2008)

Learning From Molecular Genetics: Novel Insights Arising From the Definition of Genes for Monogenic and Type 2 Diabetes
por: McCarthy, Mark I., et al.
Publicado: (2008)

Islets in Type 2 Diabetes: In Honor of Dr. Robert C. Turner
por: Bonner-Weir, Susan, et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_aqts7mbm2flpvg3l16klje8kds