Cargando…

Blunted IL17/IL22 and Pro-Inflammatory Cytokine Responses in the Genital Tract and Blood of HIV-Exposed, Seronegative Female Sex Workers in Kenya

BACKGROUND: Identifying the immune correlates of reduced susceptibility to HIV remains a key goal for the HIV vaccine field, and individuals who are HIV-exposed, seronegative (HESN) may offer important clues. Reduced systemic immune activation has been described in HESN individuals. Conversely, pro-...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chege, Duncan, Chai, Yijie, Huibner, Sanja, Kain, Taylor, Wachihi, Charles, Kimani, Makubo, Barasa, Samson, McKinnon, Lyle R., Muriuki, Festus K., Kariri, Anthony, Jaoko, Walter, Anzala, Omu, Kimani, Joshua, Ball, T. Blake, Plummer, Francis A., Kaul, Rupert
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3425491/ https://www.ncbi.nlm.nih.gov/pubmed/22928014 http://dx.doi.org/10.1371/journal.pone.0043670

Ejemplares similares

Evaluation of a Quantitative Real-Time PCR Assay to Measure HIV-Specific Mucosal CD8+ T Cell Responses in the Cervix
por: Chege, Duncan, et al.
Publicado: (2010)

HIV-1 Clade D Is Associated with Increased Rates of CD4 Decline in a Kenyan Cohort
por: McKinnon, Lyle R., et al.
Publicado: (2012)

Effect of Baseline HIV Disease Parameters on CD4+ T Cell Recovery After Antiretroviral Therapy Initiation in Kenyan Women
por: McKinnon, Lyle R., et al.
Publicado: (2010)

Does antiretroviral therapy initiation increase sexual risk taking in Kenyan female sex workers? A retrospective case–control study
por: Mawji, Elysha, et al.
Publicado: (2012)

Enumeration of Sex Workers in the Central Business District of Nairobi, Kenya
por: Kimani, Joshua, et al.
Publicado: (2013)

Correction: Enumeration of Sex Workers in the Central Business District of Nairobi, Kenya
por: Kimani, Joshua, et al.
Publicado: (2013)

P16-15. Epitope mapping of HIV-specific CD8+ T-cells responses by polyfunctional and proliferation responses reveal distinct specificity defined by function
por: Richmond, ME, et al.
Publicado: (2009)

Urinary interleukins (IL)-6 and IL-10 in schoolchildren from an area with low prevalence of Schistosoma haematobium infections in coastal Kenya
por: Njaanake, Kariuki H., et al.
Publicado: (2023)

Interferon Regulatory Factor 1 Polymorphisms Previously Associated with Reduced HIV Susceptibility Have No Effect on HIV Disease Progression
por: Sivro, Aida, et al.
Publicado: (2013)

P16-35. Specific CD4 responses to HIV-1 epitopes in exposed seronegative (ESN) versus infected commercial sex workers
por: Kiguoya, MW, et al.
Publicado: (2009)

Prevalence and risk factors of three curable sexually transmitted infections among women in Nairobi, Kenya
por: Maina, Anne Njeri, et al.
Publicado: (2016)

HIV-1 RNA Dysregulates the Natural TLR Response to Subclinical Endotoxemia in Kenyan Female Sex-Workers
por: Lester, Richard T., et al.
Publicado: (2009)

Epitope Mapping of HIV-Specific CD8+ T cells in a Cohort Dominated by Clade A1 Infection
por: McKinnon, Lyle R., et al.
Publicado: (2009)

Age and CD4(+) T cell counts are inversely associated with HIV drug resistance mutations in treatment naive female sex workers
por: Mulinge, Martin M., et al.
Publicado: (2023)

Live Attenuated Zoster Vaccine Boosts Varicella Zoster Virus (VZV)–Specific Humoral Responses Systemically and at the Cervicovaginal Mucosa of Kenyan VZV-Seropositive Women
por: Perciani, Catia T, et al.
Publicado: (2018)

Net charge and position 22 of the V3 loop are associated with HIV-1 tropism in recently infected female sex workers in Nairobi, Kenya
por: Abisi, Hellen K, et al.
Publicado: (2022)

T cell immune quiescence as a contributor to resistance to infection among HIV Exposed Seronegative (HESN) commercial sex workers from Nairobi, Kenya
por: Fowke, KR, et al.
Publicado: (2012)

Cultured enzyme-linked immunospot assay (ELISPOT) enhances detection of low HIV-specific immune responses in exposed seronegative individuals in Kenya
por: Muturi, Margaret, et al.
Publicado: (2006)

Increased epithelial thickness and reduced HIV receptor expression in the ectocervical mucosa is associated with relative HIV resistance
por: Broliden, K, et al.
Publicado: (2012)

Multidrug-Resistant Bacterial Isolates Recovered from Herbal Medicinal Products Sold in Nairobi, Kenya
por: Korir, Richard, et al.
Publicado: (2017)

P16-27.Optimization of the expansion of antigen-specific CD8+ T-cells for use in a viral suppression assay
por: Herman, MM, et al.
Publicado: (2009)

Emergency departments as under-utilized venues to provide HIV prevention services to female sex workers in Nairobi, Kenya
por: Poxon, Amanda, et al.
Publicado: (2023)

CD26/dipeptidyl peptidase IV (CD26/DPPIV) is highly expressed in peripheral blood of HIV-1 exposed uninfected Female sex workers
por: Songok, Elijah M, et al.
Publicado: (2010)

Selection, Phenotyping and Identification of Acid and Hydrogen Peroxide Producing Bacteria from Vaginal Samples of Canadian and East African Women
por: Schellenberg, John J., et al.
Publicado: (2012)

Reduced Cellular Susceptibility to In Vitro HIV Infection Is Associated with CD4+ T Cell Quiescence
por: Card, Catherine M., et al.
Publicado: (2012)

Treatment Success Following Standard Antibiotic Treatment for Bacterial Vaginosis Is Not Associated With Pretreatment Genital Immune or Microbial Parameters
por: Armstrong, Eric, et al.
Publicado: (2023)

Demystifying MOGAD and Double Seronegative NMOSD Further With IL-6 Blockade
por: Yong, Kok Pin, et al.
Publicado: (2021)

Hepatitis B status and associated factors among participants screened for simulated HIV vaccine efficacy trials in Kenya and Uganda
por: Mayanja, Yunia, et al.
Publicado: (2023)

Age and menopause affect the expression of specific cytokines/chemokines in plasma and cervical lavage samples from female sex workers in Nairobi, Kenya
por: Sivro, Aida, et al.
Publicado: (2013)

αEβ7, α4β7 and α4β1 integrin contributions to T cell distribution in blood, cervix and rectal tissues: Potential implications for HIV transmission
por: Perciani, Catia T., et al.
Publicado: (2018)

Infectious disease modelling for SARS-CoV-2 in Africa to guide policy: A systematic review
por: Kimani, Teresia Njoki, et al.
Publicado: (2022)

Intimate partner and client‐perpetrated violence are associated with reduced HIV pre‐exposure prophylaxis (PrEP) uptake, depression and generalized anxiety in a cross‐sectional study of female sex workers from Nairobi, Kenya
por: Leis, Maria, et al.
Publicado: (2021)

Influence of HLA Class I Haplotypes on HIV-1 Seroconversion and Disease Progression in Pumwani Sex Worker Cohort
por: Sampathkumar, Raghavan, et al.
Publicado: (2014)

Correction: Non-Cationic Proteins Are Associated with HIV Neutralizing Activity in Genital Secretions of Female Sex Workers
por: Birse, Kenzie D. M., et al.
Publicado: (2015)

Non-Cationic Proteins Are Associated with HIV Neutralizing Activity in Genital Secretions of Female Sex Workers
por: Birse, Kenzie D. M., et al.
Publicado: (2015)

Quantifying rates of HIV-1 flow between risk groups and geographic locations in Kenya: A country-wide phylogenetic study
por: Nduva, George M, et al.
Publicado: (2022)

High prevalence of non-communicable diseases among key populations enrolled at a large HIV prevention & treatment program in Kenya
por: Achwoka, Dunstan, et al.
Publicado: (2020)

Increased Cervical CD4(+)CCR5(+) T Cells Among Kenyan Sex Working Women Using Depot Medroxyprogesterone Acetate
por: Lajoie, Julie, et al.
Publicado: (2019)

Anti-HIV-1 Activity of Elafin Depends on Its Nuclear Localization and Altered Innate Immune Activation in Female Genital Epithelial Cells
por: Drannik, Anna G., et al.
Publicado: (2012)

A late IL-33 response after exposure to Schistosoma haematobium antigen is associated with an up-regulation of IL-13 in human eosinophils
por: Wilson, S, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_5r4tdu74nus9sibctn1hak3ab1