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Early-to-Mid Gestation Fetal Testosterone Increases Right Hand 2D∶4D Finger Length Ratio in Polycystic Ovary Syndrome-Like Monkeys

A smaller length ratio for the second relative to the fourth finger (2D∶4D) is repeatedly associated with fetal male-typical testosterone (T) and is implicated as a biomarker for a variety of traits and susceptibility to a number of diseases, but no experimental human studies have been performed. Th...

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Autores principales: Abbott, Andrew D., Colman, Ricki J., Tiefenthaler, Ross, Dumesic, Daniel A., Abbott, David H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3425513/
https://www.ncbi.nlm.nih.gov/pubmed/22927929
http://dx.doi.org/10.1371/journal.pone.0042372
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author Abbott, Andrew D.
Colman, Ricki J.
Tiefenthaler, Ross
Dumesic, Daniel A.
Abbott, David H.
author_facet Abbott, Andrew D.
Colman, Ricki J.
Tiefenthaler, Ross
Dumesic, Daniel A.
Abbott, David H.
author_sort Abbott, Andrew D.
collection PubMed
description A smaller length ratio for the second relative to the fourth finger (2D∶4D) is repeatedly associated with fetal male-typical testosterone (T) and is implicated as a biomarker for a variety of traits and susceptibility to a number of diseases, but no experimental human studies have been performed. The present study utilizes the rhesus monkey, a close relative of humans, and employs discrete gestational exposure of female monkeys to fetal male-typical T levels for 15–35 days during early-to-mid (40–76 days; n = 7) or late (94–139 days; n = 7) gestation (term: 165 days) by daily subcutaneous injection of their dams with 10 mg T propionate. Such gestational exposures are known to enhance male-typical behavior. In this study, compared to control females (n = 19), only early-to-mid gestation T exposure virilizes female external genitalia while increasing 2D∶4D ratio in the right hand (RH) by male-like elongation of RH2D. RH2D length and 2D∶4D positively correlate with androgen-dependent anogenital distance (AG), and RH2D and AG positively correlate with duration of early-to-mid gestation T exposure. Male monkeys (n = 9) exhibit a sexually dimorphic 2D∶4D in the right foot, but this trait is not emulated by early-to-mid or late gestation T exposed females. X-ray determined phalanx measurements indicate elongated finger and toe phalanx length in males, but no other phalanx-related differences. Discrete T exposure during early-to-mid gestation in female rhesus monkeys thus appears to increase RH2D∶4D through right-side biased, non-skeletal tissue growth. As variation in timing and duration of gestational T exposure alter male-like dimensions of RH2D independently of RH4D, postnatal RH2D∶4D provides a complex biomarker for fetal T exposure.
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spelling pubmed-34255132012-08-27 Early-to-Mid Gestation Fetal Testosterone Increases Right Hand 2D∶4D Finger Length Ratio in Polycystic Ovary Syndrome-Like Monkeys Abbott, Andrew D. Colman, Ricki J. Tiefenthaler, Ross Dumesic, Daniel A. Abbott, David H. PLoS One Research Article A smaller length ratio for the second relative to the fourth finger (2D∶4D) is repeatedly associated with fetal male-typical testosterone (T) and is implicated as a biomarker for a variety of traits and susceptibility to a number of diseases, but no experimental human studies have been performed. The present study utilizes the rhesus monkey, a close relative of humans, and employs discrete gestational exposure of female monkeys to fetal male-typical T levels for 15–35 days during early-to-mid (40–76 days; n = 7) or late (94–139 days; n = 7) gestation (term: 165 days) by daily subcutaneous injection of their dams with 10 mg T propionate. Such gestational exposures are known to enhance male-typical behavior. In this study, compared to control females (n = 19), only early-to-mid gestation T exposure virilizes female external genitalia while increasing 2D∶4D ratio in the right hand (RH) by male-like elongation of RH2D. RH2D length and 2D∶4D positively correlate with androgen-dependent anogenital distance (AG), and RH2D and AG positively correlate with duration of early-to-mid gestation T exposure. Male monkeys (n = 9) exhibit a sexually dimorphic 2D∶4D in the right foot, but this trait is not emulated by early-to-mid or late gestation T exposed females. X-ray determined phalanx measurements indicate elongated finger and toe phalanx length in males, but no other phalanx-related differences. Discrete T exposure during early-to-mid gestation in female rhesus monkeys thus appears to increase RH2D∶4D through right-side biased, non-skeletal tissue growth. As variation in timing and duration of gestational T exposure alter male-like dimensions of RH2D independently of RH4D, postnatal RH2D∶4D provides a complex biomarker for fetal T exposure. Public Library of Science 2012-08-22 /pmc/articles/PMC3425513/ /pubmed/22927929 http://dx.doi.org/10.1371/journal.pone.0042372 Text en © 2012 Abbott et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Abbott, Andrew D.
Colman, Ricki J.
Tiefenthaler, Ross
Dumesic, Daniel A.
Abbott, David H.
Early-to-Mid Gestation Fetal Testosterone Increases Right Hand 2D∶4D Finger Length Ratio in Polycystic Ovary Syndrome-Like Monkeys
title Early-to-Mid Gestation Fetal Testosterone Increases Right Hand 2D∶4D Finger Length Ratio in Polycystic Ovary Syndrome-Like Monkeys
title_full Early-to-Mid Gestation Fetal Testosterone Increases Right Hand 2D∶4D Finger Length Ratio in Polycystic Ovary Syndrome-Like Monkeys
title_fullStr Early-to-Mid Gestation Fetal Testosterone Increases Right Hand 2D∶4D Finger Length Ratio in Polycystic Ovary Syndrome-Like Monkeys
title_full_unstemmed Early-to-Mid Gestation Fetal Testosterone Increases Right Hand 2D∶4D Finger Length Ratio in Polycystic Ovary Syndrome-Like Monkeys
title_short Early-to-Mid Gestation Fetal Testosterone Increases Right Hand 2D∶4D Finger Length Ratio in Polycystic Ovary Syndrome-Like Monkeys
title_sort early-to-mid gestation fetal testosterone increases right hand 2d∶4d finger length ratio in polycystic ovary syndrome-like monkeys
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3425513/
https://www.ncbi.nlm.nih.gov/pubmed/22927929
http://dx.doi.org/10.1371/journal.pone.0042372
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