Cargando…

HDAC6 Inhibitor Blocks Amyloid Beta-Induced Impairment of Mitochondrial Transport in Hippocampal Neurons

Even though the disruption of axonal transport is an important pathophysiological factor in neurodegenerative diseases including Alzheimer's disease (AD), the relationship between disruption of axonal transport and pathogenesis of AD is poorly understood. Considering that α-tubulin acetylation...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kim, Chaeyoung, Choi, Heesun, Jung, Eun Sun, Lee, Wonik, Oh, Soojung, Jeon, Noo Li, Mook-Jung, Inhee
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3425572/ https://www.ncbi.nlm.nih.gov/pubmed/22937007 http://dx.doi.org/10.1371/journal.pone.0042983

Ejemplares similares

Increased acetylation of Peroxiredoxin1 by HDAC6 inhibition leads to recovery of Aβ-induced impaired axonal transport
por: Choi, Heesun, et al.
Publicado: (2017)

Amyloid β‐induced elevation of O‐GlcNAcylated c‐Fos promotes neuronal cell death
por: Choi, Heesun, et al.
Publicado: (2018)

Acute ER stress regulates amyloid precursor protein processing through ubiquitin-dependent degradation
por: Jung, Eun Sun, et al.
Publicado: (2015)

HDAC6 Regulates Mitochondrial Transport in Hippocampal Neurons
por: Chen, Sigeng, et al.
Publicado: (2010)

HDAC6 Inhibitors Rescued the Defective Axonal Mitochondrial Movement in Motor Neurons Derived from the Induced Pluripotent Stem Cells of Peripheral Neuropathy Patients with HSPB1 Mutation
por: Kim, Ji-Yon, et al.
Publicado: (2016)

Cytosolic Extract of Human Adipose Stem Cells Reverses the Amyloid Beta-Induced Mitochondrial Apoptosis via P53/Foxo3a Pathway
por: Liu, Tian, et al.
Publicado: (2017)

Thrombospondin-1 protects against Aβ-induced mitochondrial fragmentation and dysfunction in hippocampal cells
por: Kang, Seokjo, et al.
Publicado: (2018)

Amyloid-Beta Induced Changes in Vesicular Transport of BDNF in Hippocampal Neurons
por: Seifert, Bianca, et al.
Publicado: (2016)

Amyloid Beta-Mediated Epigenetic Alteration of Insulin-Like Growth Factor Binding Protein 3 Controls Cell Survival in Alzheimer's Disease
por: Sung, Hye Youn, et al.
Publicado: (2014)

The effects of amyloid-beta on hippocampal glutamatergic receptor and transporter expression
por: Kwakowsky, Andrea, et al.
Publicado: (2020)

Visualization of Altered Hippocampal Connectivity in an Animal Model of Alzheimer’s Disease
por: Jeon, Seong Gak, et al.
Publicado: (2018)

Statins induce insulin-degrading enzyme secretion from astrocytes via an autophagy-based unconventional secretory pathway
por: Son, Sung Min, et al.
Publicado: (2015)

Annexin A1 restores Aβ(1‐42)‐induced blood–brain barrier disruption through the inhibition of RhoA‐ROCK signaling pathway
por: Park, Jong‐Chan, et al.
Publicado: (2016)

The role of cell type-specific mitochondrial dysfunction in the pathogenesis of Alzheimer’s disease
por: Kim, Dong Kyu, et al.
Publicado: (2019)

Mitochondria-Specific Accumulation of Amyloid β Induces Mitochondrial Dysfunction Leading to Apoptotic Cell Death
por: Cha, Moon-Yong, et al.
Publicado: (2012)

Influence of amyloid beta on impulse spiking of isolated hippocampal neurons
por: Yavorsky, Volodymyr A., et al.
Publicado: (2023)

Effective screen for amyloid β aggregation inhibitor using amyloid β-conjugated gold nanoparticles
por: Han, Sun-Ho, et al.
Publicado: (2011)

The role of mitochondrial DNA mutation on neurodegenerative diseases
por: Cha, Moon-Yong, et al.
Publicado: (2015)

Deacetylation of Miro1 by HDAC6 blocks mitochondrial transport and mediates axon growth inhibition
por: Kalinski, Ashley L., et al.
Publicado: (2019)

Knock-Down of HDAC2 in Human Induced Pluripotent Stem Cell Derived Neurons Improves Neuronal Mitochondrial Dynamics, Neuronal Maturation and Reduces Amyloid Beta Peptides
por: Frankowski, Harald, et al.
Publicado: (2021)

The novel RAGE interactor PRAK is associated with autophagy signaling in Alzheimer’s disease pathogenesis
por: Kim, Yoonhee, et al.
Publicado: (2016)

Troxerutin protects hippocampal neurons against amyloid beta-induced oxidative stress and apoptosis
por: Farajdokht, Fereshteh, et al.
Publicado: (2017)

Amyloid‐β activates NLRP3 inflammasomes by affecting microglial immunometabolism through the Syk‐AMPK pathway
por: Jung, Eun Sun, et al.
Publicado: (2022)

Investigating the effects of beta-amyloid on hippocampal signalling in Alzheimer's disease
por: Warburton, Julia M, et al.
Publicado: (2015)

Dynamics of axonal β‐actin mRNA in live hippocampal neurons
por: Lee, Byung Hun, et al.
Publicado: (2022)

miR-351-5p/Miro2 axis contributes to hippocampal neural progenitor cell death via unbalanced mitochondrial fission
por: Woo, Ha-Na, et al.
Publicado: (2020)

Elevated amyloid beta disrupts the nanoscale organization and function of synaptic vesicle pools in hippocampal neurons
por: Biasetti, Luca, et al.
Publicado: (2022)

Synapsin-1 and tau reciprocal O-GlcNAcylation and phosphorylation sites in mouse brain synaptosomes
por: Kang, Min Jueng, et al.
Publicado: (2013)

Increased O-GlcNAcylation of Drp1 by amyloid-beta promotes mitochondrial fission and dysfunction in neuronal cells
por: Park, So Jung, et al.
Publicado: (2021)

Amyloid Beta Peptide Slows Down Sensory-Induced Hippocampal Oscillations
por: Peña-Ortega, Fernando, et al.
Publicado: (2012)

Computational modeling of the effects of amyloid-beta on release probability at hippocampal synapses
por: Romani, Armando, et al.
Publicado: (2013)

Amyloid Beta Peptides Differentially Affect Hippocampal Theta Rhythms In Vitro
por: Gutiérrez-Lerma, Armando I., et al.
Publicado: (2013)

Hyperexcitable Parvalbumin Interneurons Render Hippocampal Circuitry Vulnerable to Amyloid Beta
por: Hijazi, Sara, et al.
Publicado: (2020)

Association of Hippocampal Subfield Volumes with Amyloid-Beta Deposition in Alzheimer’s Disease
por: Baek, Min Seok, et al.
Publicado: (2022)

Special issue on neurodegenerative diseases and their therapeutic approaches
por: Kim, Jungsu, et al.
Publicado: (2015)

PRAK mediates Aβ-RAGE driven autophagy pathway
por: Kim, Yoonhee, et al.
Publicado: (2017)

A quadrupolar two-photon fluorescent probe for in vivo imaging of amyloid-β plaques
por: Heo, Cheol Ho, et al.
Publicado: (2016)

A Bifunctional Anti-Amyloid Blocks Oxidative Stress and the Accumulation of Intraneuronal Amyloid-Beta
por: Hilt, Silvia, et al.
Publicado: (2018)

Soluble amyloid beta oligomers block the learning-induced increase in hippocampal sharp wave-ripple rate and impair spatial memory formation
por: Nicole, Olivier, et al.
Publicado: (2016)

Diverse Molecular Targets for Therapeutic Strategies in Alzheimer's Disease
por: Han, Sun-Ho, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_27erlifqc4eiv1p7rcaruru2nr