Cargando…

Ocular safety of cationic emulsion of cyclosporine in an in vitro corneal wound-healing model and an acute in vivo rabbit model

PURPOSE: Topical preparations of cyclosporine (CsA) are common therapeutics for the treatment of dry eye. However, they are not devoid of side effects, such as allergy and irritation. The present study aimed at evaluating the safety profile of a new CsA formulation in cationic emulsion (CEm) in vitr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liang, Hong, Baudouin, Christophe, Daull, Philippe, Garrigue, Jean-Sébastien, Brignole-Baudouin, Françoise
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Molecular Vision 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3425577/ https://www.ncbi.nlm.nih.gov/pubmed/22919267

Ejemplares similares

Use of a Cationic Emulsion of Latanoprost to Treat Glaucoma Patients with Ocular Surface Disease: A Preclinical Review
por: Daull, Philippe, et al.
Publicado: (2023)

Comparison of the ocular tolerability of a latanoprost cationic emulsion versus conventional formulations of prostaglandins: an in vivo toxicity assay
por: Liang, Hong, et al.
Publicado: (2009)

Cationic Emulsion-Based Artificial Tears as a Mimic of Functional Healthy Tear Film for Restoration of Ocular Surface Homeostasis in Dry Eye Disease
por: Daull, Philippe, et al.
Publicado: (2020)

Comparison of Two Experimental Mouse Dry Eye Models through Inflammatory Gene Set Enrichment Analysis Based on a Multiplexed Transcriptomic Approach
por: Kessal, Karima, et al.
Publicado: (2021)

One-Year Efficacy and Safety of 0.1% Cyclosporine a Cationic Emulsion in the Treatment of Severe Dry Eye Disease
por: Baudouin, Christophe, et al.
Publicado: (2017)

A Randomized Study of the Efficacy and Safety of 0.1% Cyclosporine a Cationic Emulsion in Treatment of Moderate to Severe Dry Eye
por: Baudouin, Christophe, et al.
Publicado: (2017)

Conjunctival Inflammatory Gene Expression Profiling in Dry Eye Disease: Correlations With HLA-DRA and HLA-DRB1
por: Kessal, Karima, et al.
Publicado: (2018)

Reduction of quaternary ammonium-induced ocular surface toxicity by emulsions: an in vivo study in rabbits
por: Liang, H., et al.
Publicado: (2008)

In Vitro Inhibition of NFAT5-Mediated Induction of CCL2 in Hyperosmotic Conditions by Cyclosporine and Dexamethasone on Human HeLa-Modified Conjunctiva-Derived Cells
por: Warcoin, Elise, et al.
Publicado: (2016)

The corneal endothelium in an endotoxin-induced uveitis model: correlation between in vivo confocal microscopy and immunohistochemistry
por: Trinh, Liem, et al.
Publicado: (2008)

Anti-inflammatory activity of CKC-containing cationic emulsion eye drop vehicles
por: Daull, Philippe, et al.
Publicado: (2018)

Topical ocular 0.1% cyclosporine A cationic emulsion in dry eye disease patients with severe keratitis: experience through the French early-access program
por: Pisella, Pierre-Jean, et al.
Publicado: (2018)

Conjunctiva-Associated Lymphoid Tissue (CALT) Reactions to Antiglaucoma Prostaglandins with or without BAK-Preservative in Rabbit Acute Toxicity Study
por: Liang, Hong, et al.
Publicado: (2012)

Toxicological evaluation of preservative-containing and preservative-free topical prostaglandin analogues on a three-dimensional-reconstituted corneal epithelium system
por: Liang, Hong, et al.
Publicado: (2011)

Conjunctival and corneal reactions in rabbits following short- and repeated exposure to preservative-free tafluprost, commercially available latanoprost and 0.02% benzalkonium chloride
por: Liang, H, et al.
Publicado: (2008)

Successfully Improving Ocular Drug Delivery Using the Cationic Nanoemulsion, Novasorb
por: Lallemand, Frederic, et al.
Publicado: (2012)

Th1- and Th2-related chemokine and chemokine receptor expression on the ocular surface in endotoxin-induced uveitis
por: Trinh, Liem, et al.
Publicado: (2008)

Effects of toxic cellular stresses and divalent cations on the human P2X7 cell death receptor
por: Dutot, Mélody, et al.
Publicado: (2008)

Shhedding New Light on the Role of Hedgehog Signaling in Corneal Wound Healing
por: Zhang, Xin, et al.
Publicado: (2022)

Profiling tear film enzymes reveals major metabolic pathways involved in the homeostasis of the ocular surface
por: Akkurt Arslan, Murat, et al.
Publicado: (2023)

Multiple endpoint analysis of BAC-preserved and unpreserved antiallergic eye drops on a 3D-reconstituted corneal epithelial model
por: Pauly, A., et al.
Publicado: (2011)

Comparison of the Anti-Inflammatory Effects of Artificial Tears in a Rat Model of Corneal Scraping
por: Daull, Philippe, et al.
Publicado: (2016)

CXCR3 Antagonism of SDF-1(5-67) Restores Trabecular Function and Prevents Retinal Neurodegeneration in a Rat Model of Ocular Hypertension
por: Denoyer, Alexandre, et al.
Publicado: (2012)

Benefits of cetalkonium chloride cationic oil-in-water nanoemulsions for topical ophthalmic drug delivery
por: Daull, Philippe, et al.
Publicado: (2014)

The Dual Effect of Rho-Kinase Inhibition on Trabecular Meshwork Cells Cytoskeleton and Extracellular Matrix in an In Vitro Model of Glaucoma
por: Buffault, Juliette, et al.
Publicado: (2022)

The Eye Drop Preservative Benzalkonium Chloride Potently Induces Mitochondrial Dysfunction and Preferentially Affects LHON Mutant Cells
por: Datta, Sandipan, et al.
Publicado: (2017)

Healing Ability of Central Corneal Epithelium in Rabbit Ocular Surface Injury Models
por: Zhang, Wang, et al.
Publicado: (2022)

Effects of different sutures on fibrosis and wound healing in a rabbit model of corneal wounds
por: Li, Ying, et al.
Publicado: (2016)

Safety and Tolerability of Overdosed Artificial Tears by Abraded Rabbit Corneas
por: Daull, Philippe, et al.
Publicado: (2018)

Efficacy and safety of 0.1% ciclosporin A cationic emulsion in dry eye disease: a pooled analysis of two double-masked, randomised, vehicle-controlled phase III clinical studies
por: Leonardi, Andrea, et al.
Publicado: (2019)

Hyperosmolarity potentiates toxic effects of benzalkonium chloride on conjunctival epithelial cells in vitro
por: Clouzeau, Chloé, et al.
Publicado: (2012)

Effects of Benzalkonium Chloride on THP-1 Differentiated Macrophages In Vitro
por: Michée, Sylvain, et al.
Publicado: (2013)

Lipid Annotation by Combination of UHPLC-HRMS (MS), Molecular Networking, and Retention Time Prediction: Application to a Lipidomic Study of In Vitro Models of Dry Eye Disease
por: Magny, Romain, et al.
Publicado: (2020)

Evaluation of neuroprotective and immunomodulatory properties of mesenchymal stem cells in an ex vivo retinal explant model
por: Reboussin, Élodie, et al.
Publicado: (2022)

Effect of Topically Administered Chitosan-N-acetylcysteine on Corneal Wound Healing in a Rabbit Model
por: Fischak, Corinna, et al.
Publicado: (2017)

Comparative analysis of 0.1% cyclosporin A cationic emulsion and 0.05% cyclosporin A emulsion in murine dry eye cases with different severities
por: Jin, Rujun, et al.
Publicado: (2021)

Proteomic Analysis of Tears and Conjunctival Cells Collected with Schirmer Strips Using timsTOF Pro: Preanalytical Considerations
por: Akkurt Arslan, Murat, et al.
Publicado: (2021)

A New Safety Concern for Glaucoma Treatment Demonstrated by Mass Spectrometry Imaging of Benzalkonium Chloride Distribution in the Eye, an Experimental Study in Rabbits
por: Brignole-Baudouin, Françoise, et al.
Publicado: (2012)

Correction: A New Safety Concern for Glaucoma Treatment Demonstrated by Mass Spectrometry Imaging of Benzalkonium Chloride Distribution in the Eye, an Experimental Study in Rabbits
por: Brignole-Baudouin, Françoise, et al.
Publicado: (2013)

Challenges in the clinical measurement of ocular surface disease in glaucoma patients
por: Pflugfelder, Stephen C, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_ifr57g2rv089u7uji5fk140vgm