Critical role for cochlear hair cell BK channels for coding the temporal structure and dynamic range of auditory information for central auditory processing

Large conductance, voltage- and Ca(2+)-activated K(+) (BK) channels in inner hair cells (IHCs) of the cochlea are essential for hearing. However, germline deletion of BKα, the pore-forming subunit KCNMA1 of the BK channel, surprisingly did not affect hearing thresholds in the first postnatal weeks,...

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Autores principales: Kurt, Simone, Sausbier, Matthias, Rüttiger, Lukas, Brandt, Niels, Moeller, Christoph K., Kindler, Jennifer, Sausbier, Ulrike, Zimmermann, Ulrike, van Straaten, Harald, Neuhuber, Winfried, Engel, Jutta, Knipper, Marlies, Ruth, Peter, Schulze, Holger
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Federation of American Societies for Experimental Biology 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3425825/
https://www.ncbi.nlm.nih.gov/pubmed/22691916
http://dx.doi.org/10.1096/fj.11-200535
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author Kurt, Simone
Sausbier, Matthias
Rüttiger, Lukas
Brandt, Niels
Moeller, Christoph K.
Kindler, Jennifer
Sausbier, Ulrike
Zimmermann, Ulrike
van Straaten, Harald
Neuhuber, Winfried
Engel, Jutta
Knipper, Marlies
Ruth, Peter
Schulze, Holger
author_facet Kurt, Simone
Sausbier, Matthias
Rüttiger, Lukas
Brandt, Niels
Moeller, Christoph K.
Kindler, Jennifer
Sausbier, Ulrike
Zimmermann, Ulrike
van Straaten, Harald
Neuhuber, Winfried
Engel, Jutta
Knipper, Marlies
Ruth, Peter
Schulze, Holger
author_sort Kurt, Simone
collection PubMed
description Large conductance, voltage- and Ca(2+)-activated K(+) (BK) channels in inner hair cells (IHCs) of the cochlea are essential for hearing. However, germline deletion of BKα, the pore-forming subunit KCNMA1 of the BK channel, surprisingly did not affect hearing thresholds in the first postnatal weeks, even though altered IHC membrane time constants, decreased IHC receptor potential alternating current/direct current ratio, and impaired spike timing of auditory fibers were reported in these mice. To investigate the role of IHC BK channels for central auditory processing, we generated a conditional mouse model with hair cell-specific deletion of BKα from postnatal day 10 onward. This had an unexpected effect on temporal coding in the central auditory system: neuronal single and multiunit responses in the inferior colliculus showed higher excitability and greater precision of temporal coding that may be linked to the improved discrimination of temporally modulated sounds observed in behavioral training. The higher precision of temporal coding, however, was restricted to slower modulations of sound and reduced stimulus-driven activity. This suggests a diminished dynamic range of stimulus coding that is expected to impair signal detection in noise. Thus, BK channels in IHCs are crucial for central coding of the temporal fine structure of sound and for detection of signals in a noisy environment.—Kurt, S., Sausbier, M., Rüttiger, L., Brandt, N., Moeller, C. K., Kindler, J., Sausbier, U., Zimmermann, U., van Straaten, H., Neuhuber, W., Engel, J., Knipper, M., Ruth, P., Schulze, H. Critical role for cochlear hair cell BK channels for coding the temporal structure and dynamic range of auditory information for central auditory processing.
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spelling pubmed-34258252012-09-05 Critical role for cochlear hair cell BK channels for coding the temporal structure and dynamic range of auditory information for central auditory processing Kurt, Simone Sausbier, Matthias Rüttiger, Lukas Brandt, Niels Moeller, Christoph K. Kindler, Jennifer Sausbier, Ulrike Zimmermann, Ulrike van Straaten, Harald Neuhuber, Winfried Engel, Jutta Knipper, Marlies Ruth, Peter Schulze, Holger FASEB J Research Communications Large conductance, voltage- and Ca(2+)-activated K(+) (BK) channels in inner hair cells (IHCs) of the cochlea are essential for hearing. However, germline deletion of BKα, the pore-forming subunit KCNMA1 of the BK channel, surprisingly did not affect hearing thresholds in the first postnatal weeks, even though altered IHC membrane time constants, decreased IHC receptor potential alternating current/direct current ratio, and impaired spike timing of auditory fibers were reported in these mice. To investigate the role of IHC BK channels for central auditory processing, we generated a conditional mouse model with hair cell-specific deletion of BKα from postnatal day 10 onward. This had an unexpected effect on temporal coding in the central auditory system: neuronal single and multiunit responses in the inferior colliculus showed higher excitability and greater precision of temporal coding that may be linked to the improved discrimination of temporally modulated sounds observed in behavioral training. The higher precision of temporal coding, however, was restricted to slower modulations of sound and reduced stimulus-driven activity. This suggests a diminished dynamic range of stimulus coding that is expected to impair signal detection in noise. Thus, BK channels in IHCs are crucial for central coding of the temporal fine structure of sound and for detection of signals in a noisy environment.—Kurt, S., Sausbier, M., Rüttiger, L., Brandt, N., Moeller, C. K., Kindler, J., Sausbier, U., Zimmermann, U., van Straaten, H., Neuhuber, W., Engel, J., Knipper, M., Ruth, P., Schulze, H. Critical role for cochlear hair cell BK channels for coding the temporal structure and dynamic range of auditory information for central auditory processing. Federation of American Societies for Experimental Biology 2012-09 /pmc/articles/PMC3425825/ /pubmed/22691916 http://dx.doi.org/10.1096/fj.11-200535 Text en © FASEB This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/us/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Communications
Kurt, Simone
Sausbier, Matthias
Rüttiger, Lukas
Brandt, Niels
Moeller, Christoph K.
Kindler, Jennifer
Sausbier, Ulrike
Zimmermann, Ulrike
van Straaten, Harald
Neuhuber, Winfried
Engel, Jutta
Knipper, Marlies
Ruth, Peter
Schulze, Holger
Critical role for cochlear hair cell BK channels for coding the temporal structure and dynamic range of auditory information for central auditory processing
title Critical role for cochlear hair cell BK channels for coding the temporal structure and dynamic range of auditory information for central auditory processing
title_full Critical role for cochlear hair cell BK channels for coding the temporal structure and dynamic range of auditory information for central auditory processing
title_fullStr Critical role for cochlear hair cell BK channels for coding the temporal structure and dynamic range of auditory information for central auditory processing
title_full_unstemmed Critical role for cochlear hair cell BK channels for coding the temporal structure and dynamic range of auditory information for central auditory processing
title_short Critical role for cochlear hair cell BK channels for coding the temporal structure and dynamic range of auditory information for central auditory processing
title_sort critical role for cochlear hair cell bk channels for coding the temporal structure and dynamic range of auditory information for central auditory processing
topic Research Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3425825/
https://www.ncbi.nlm.nih.gov/pubmed/22691916
http://dx.doi.org/10.1096/fj.11-200535
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