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Cholesterol-Lowering Effect of Allicin on Hypercholesterolemic ICR Mice
Allicin was discussed as an active compound with regard to the beneficial effects of garlic in atherosclerosis. The aim of this study was to investigate the cholesterol-lowering properties of allicin. In order to examine its effects on hypercholesterolemia in male ICR mice, this compound with doses...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3425886/ https://www.ncbi.nlm.nih.gov/pubmed/22928080 http://dx.doi.org/10.1155/2012/489690 |
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author | Lu, Yin He, Zhuojin Shen, Xiuying Xu, Xiaolu Fan, Jie Wu, Shaohua Zhang, Deyong |
author_facet | Lu, Yin He, Zhuojin Shen, Xiuying Xu, Xiaolu Fan, Jie Wu, Shaohua Zhang, Deyong |
author_sort | Lu, Yin |
collection | PubMed |
description | Allicin was discussed as an active compound with regard to the beneficial effects of garlic in atherosclerosis. The aim of this study was to investigate the cholesterol-lowering properties of allicin. In order to examine its effects on hypercholesterolemia in male ICR mice, this compound with doses of 5, 10, or 20 mg/kg body weight was given orally daily for 12 weeks. Changes in body weight and daily food intake were measured regularly during the experimental period. Final contents of serum cholesterol, triglyceride, glucose, and hepatic cholesterol storage were determined. Following a 12-week experimental period, the body weights of allicin-fed mice were less than those of control mice on a high-cholesterol diet by 38.24 ± 7.94% (P < 0.0001) with 5 mg/kg allicin, 39.28 ± 5.03% (P < 0.0001) with 10 mg/kg allicin, and 41.18 ± 5.00% (P < 0.0001) with 20 mg/kg allicin, respectively. A decrease in daily food consumption was also noted in most of the treated animals. Meanwhile, allicin showed a favorable effect in reducing blood cholesterol, triglycerides, and glucose levels and caused a significant decrease in lowering the hepatic cholesterol storage. Accordingly, both in vivo and in vitro results demonstrated a potential value of allicin as a pronounced cholesterol-lowering candidate, providing protection against the onset of atherosclerosis. |
format | Online Article Text |
id | pubmed-3425886 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-34258862012-08-27 Cholesterol-Lowering Effect of Allicin on Hypercholesterolemic ICR Mice Lu, Yin He, Zhuojin Shen, Xiuying Xu, Xiaolu Fan, Jie Wu, Shaohua Zhang, Deyong Oxid Med Cell Longev Research Article Allicin was discussed as an active compound with regard to the beneficial effects of garlic in atherosclerosis. The aim of this study was to investigate the cholesterol-lowering properties of allicin. In order to examine its effects on hypercholesterolemia in male ICR mice, this compound with doses of 5, 10, or 20 mg/kg body weight was given orally daily for 12 weeks. Changes in body weight and daily food intake were measured regularly during the experimental period. Final contents of serum cholesterol, triglyceride, glucose, and hepatic cholesterol storage were determined. Following a 12-week experimental period, the body weights of allicin-fed mice were less than those of control mice on a high-cholesterol diet by 38.24 ± 7.94% (P < 0.0001) with 5 mg/kg allicin, 39.28 ± 5.03% (P < 0.0001) with 10 mg/kg allicin, and 41.18 ± 5.00% (P < 0.0001) with 20 mg/kg allicin, respectively. A decrease in daily food consumption was also noted in most of the treated animals. Meanwhile, allicin showed a favorable effect in reducing blood cholesterol, triglycerides, and glucose levels and caused a significant decrease in lowering the hepatic cholesterol storage. Accordingly, both in vivo and in vitro results demonstrated a potential value of allicin as a pronounced cholesterol-lowering candidate, providing protection against the onset of atherosclerosis. Hindawi Publishing Corporation 2012 2012-08-09 /pmc/articles/PMC3425886/ /pubmed/22928080 http://dx.doi.org/10.1155/2012/489690 Text en Copyright © 2012 Yin Lu et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Lu, Yin He, Zhuojin Shen, Xiuying Xu, Xiaolu Fan, Jie Wu, Shaohua Zhang, Deyong Cholesterol-Lowering Effect of Allicin on Hypercholesterolemic ICR Mice |
title | Cholesterol-Lowering Effect of Allicin on Hypercholesterolemic ICR Mice |
title_full | Cholesterol-Lowering Effect of Allicin on Hypercholesterolemic ICR Mice |
title_fullStr | Cholesterol-Lowering Effect of Allicin on Hypercholesterolemic ICR Mice |
title_full_unstemmed | Cholesterol-Lowering Effect of Allicin on Hypercholesterolemic ICR Mice |
title_short | Cholesterol-Lowering Effect of Allicin on Hypercholesterolemic ICR Mice |
title_sort | cholesterol-lowering effect of allicin on hypercholesterolemic icr mice |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3425886/ https://www.ncbi.nlm.nih.gov/pubmed/22928080 http://dx.doi.org/10.1155/2012/489690 |
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