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Two-dimensional strain profiles in patients with physiological and pathological hypertrophy and preserved left ventricular systolic function: a comparative analyses

OBJECTIVE: This study was designed to examine the utility of two-dimensional strain (2DS) or speckle tracking imaging to typify functional adaptations of the left ventricle in variant forms of left ventricular hypertrophy (LVH). DESIGN: Cross-sectional study. SETTING: Urban tertiary care academic me...

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Autores principales: Afonso, Luis, Kondur, Ashok, Simegn, Mengistu, Niraj, Ashutosh, Hari, Pawan, Kaur, Ramanjit, Ramappa, Preeti, Pradhan, Jyotiranjan, Bhandare, Deepti, Williams, Kim A, Zalawadiya, Sandip, Pinheiro, Aurelio, Abraham, Theodore P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Group 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3425901/
https://www.ncbi.nlm.nih.gov/pubmed/22904333
http://dx.doi.org/10.1136/bmjopen-2012-001390
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author Afonso, Luis
Kondur, Ashok
Simegn, Mengistu
Niraj, Ashutosh
Hari, Pawan
Kaur, Ramanjit
Ramappa, Preeti
Pradhan, Jyotiranjan
Bhandare, Deepti
Williams, Kim A
Zalawadiya, Sandip
Pinheiro, Aurelio
Abraham, Theodore P
author_facet Afonso, Luis
Kondur, Ashok
Simegn, Mengistu
Niraj, Ashutosh
Hari, Pawan
Kaur, Ramanjit
Ramappa, Preeti
Pradhan, Jyotiranjan
Bhandare, Deepti
Williams, Kim A
Zalawadiya, Sandip
Pinheiro, Aurelio
Abraham, Theodore P
author_sort Afonso, Luis
collection PubMed
description OBJECTIVE: This study was designed to examine the utility of two-dimensional strain (2DS) or speckle tracking imaging to typify functional adaptations of the left ventricle in variant forms of left ventricular hypertrophy (LVH). DESIGN: Cross-sectional study. SETTING: Urban tertiary care academic medical centres. PARTICIPANTS: A total of 129 subjects, 56 with hypertrophic cardiomyopathy (HCM), 34 with hypertensive left ventricular hypertrophy (H-LVH), 27 professional athletes with LVH (AT-LVH) and 12 healthy controls in sinus rhythm with preserved left ventricular systolic function. METHODS: Conventional echocardiographic and tissue Doppler examinations were performed in all study subjects. Bi-dimensional acquisitions were analysed to map longitudinal systolic strain (automated function imaging, AFI, GE Healthcare, Waukesha, Wisconsin, USA) from apical views. RESULTS: Subjects with HCM had significantly lower regional and average global peak longitudinal systolic strain (GLS-avg) compared with controls and other forms of LVH. Strain dispersion index, a measure of regional contractile heterogeneity, was higher in HCM compared with the rest of the groups. On receiver operator characteristics analysis, GLS-avg had excellent discriminatory ability to distinguish HCM from H-LVH area under curve (AUC) (0.893, p<0.001) or AT-LVH AUC (0.920, p<0.001). Tissue Doppler and LV morphological parameters were better suited to differentiate the athlete heart from HCM. CONCLUSIONS: 2DS (AFI) allows rapid characterisation of regional and global systolic function and may have the potential to differentiate HCM from variant forms of LVH.
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spelling pubmed-34259012012-08-30 Two-dimensional strain profiles in patients with physiological and pathological hypertrophy and preserved left ventricular systolic function: a comparative analyses Afonso, Luis Kondur, Ashok Simegn, Mengistu Niraj, Ashutosh Hari, Pawan Kaur, Ramanjit Ramappa, Preeti Pradhan, Jyotiranjan Bhandare, Deepti Williams, Kim A Zalawadiya, Sandip Pinheiro, Aurelio Abraham, Theodore P BMJ Open Cardiovascular Medicine OBJECTIVE: This study was designed to examine the utility of two-dimensional strain (2DS) or speckle tracking imaging to typify functional adaptations of the left ventricle in variant forms of left ventricular hypertrophy (LVH). DESIGN: Cross-sectional study. SETTING: Urban tertiary care academic medical centres. PARTICIPANTS: A total of 129 subjects, 56 with hypertrophic cardiomyopathy (HCM), 34 with hypertensive left ventricular hypertrophy (H-LVH), 27 professional athletes with LVH (AT-LVH) and 12 healthy controls in sinus rhythm with preserved left ventricular systolic function. METHODS: Conventional echocardiographic and tissue Doppler examinations were performed in all study subjects. Bi-dimensional acquisitions were analysed to map longitudinal systolic strain (automated function imaging, AFI, GE Healthcare, Waukesha, Wisconsin, USA) from apical views. RESULTS: Subjects with HCM had significantly lower regional and average global peak longitudinal systolic strain (GLS-avg) compared with controls and other forms of LVH. Strain dispersion index, a measure of regional contractile heterogeneity, was higher in HCM compared with the rest of the groups. On receiver operator characteristics analysis, GLS-avg had excellent discriminatory ability to distinguish HCM from H-LVH area under curve (AUC) (0.893, p<0.001) or AT-LVH AUC (0.920, p<0.001). Tissue Doppler and LV morphological parameters were better suited to differentiate the athlete heart from HCM. CONCLUSIONS: 2DS (AFI) allows rapid characterisation of regional and global systolic function and may have the potential to differentiate HCM from variant forms of LVH. BMJ Group 2012-08-16 /pmc/articles/PMC3425901/ /pubmed/22904333 http://dx.doi.org/10.1136/bmjopen-2012-001390 Text en © 2012, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions. This is an open-access article distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license. See: http://creativecommons.org/licenses/by-nc/3.0/ and http://creativecommons.org/licenses/by-nc/3.0/legalcode
spellingShingle Cardiovascular Medicine
Afonso, Luis
Kondur, Ashok
Simegn, Mengistu
Niraj, Ashutosh
Hari, Pawan
Kaur, Ramanjit
Ramappa, Preeti
Pradhan, Jyotiranjan
Bhandare, Deepti
Williams, Kim A
Zalawadiya, Sandip
Pinheiro, Aurelio
Abraham, Theodore P
Two-dimensional strain profiles in patients with physiological and pathological hypertrophy and preserved left ventricular systolic function: a comparative analyses
title Two-dimensional strain profiles in patients with physiological and pathological hypertrophy and preserved left ventricular systolic function: a comparative analyses
title_full Two-dimensional strain profiles in patients with physiological and pathological hypertrophy and preserved left ventricular systolic function: a comparative analyses
title_fullStr Two-dimensional strain profiles in patients with physiological and pathological hypertrophy and preserved left ventricular systolic function: a comparative analyses
title_full_unstemmed Two-dimensional strain profiles in patients with physiological and pathological hypertrophy and preserved left ventricular systolic function: a comparative analyses
title_short Two-dimensional strain profiles in patients with physiological and pathological hypertrophy and preserved left ventricular systolic function: a comparative analyses
title_sort two-dimensional strain profiles in patients with physiological and pathological hypertrophy and preserved left ventricular systolic function: a comparative analyses
topic Cardiovascular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3425901/
https://www.ncbi.nlm.nih.gov/pubmed/22904333
http://dx.doi.org/10.1136/bmjopen-2012-001390
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