Challenging Regional Psoriasis and Ustekinumab Biotherapy: Impact of the Patterns of Disease

In some patients, psoriasis appears refractory to many treatments, particularly when the disease is confined to some specific body regions. In this respect, palmoplantar psoriasis and palmoplantar pustulosis are possibly related conditions in their immunopathomechanisms involving Il-12, IL-23, and T...

Descripción completa

Detalles Bibliográficos
Autores principales: Hermanns-Lê, Trinh, Berardesca, Enzo, Piérard, Gérald E., Lesuisse, Marianne, Piérard-Franchimont, Claudine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3425983/
https://www.ncbi.nlm.nih.gov/pubmed/22927720
http://dx.doi.org/10.1155/2012/413767
_version_ 1782241442662449152
author Hermanns-Lê, Trinh
Berardesca, Enzo
Piérard, Gérald E.
Lesuisse, Marianne
Piérard-Franchimont, Claudine
author_facet Hermanns-Lê, Trinh
Berardesca, Enzo
Piérard, Gérald E.
Lesuisse, Marianne
Piérard-Franchimont, Claudine
author_sort Hermanns-Lê, Trinh
collection PubMed
description In some patients, psoriasis appears refractory to many treatments, particularly when the disease is confined to some specific body regions. In this respect, palmoplantar psoriasis and palmoplantar pustulosis are possibly related conditions in their immunopathomechanisms involving Il-12, IL-23, and Th17. Nail psoriasis and scalp psoriasis are two other particular psoriasis manifestations. Accordingly, ustekinumab was tested in a few of these patients. The present paper is limited to peer-reviewed case reports. Data were not supported by bioinstrumental assessments and controlled trials. Overall, they are indicative of potential efficacy. The cost-effectiveness and the risk-benefit assessments merit further investigations.
format Online
Article
Text
id pubmed-3425983
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-34259832012-08-27 Challenging Regional Psoriasis and Ustekinumab Biotherapy: Impact of the Patterns of Disease Hermanns-Lê, Trinh Berardesca, Enzo Piérard, Gérald E. Lesuisse, Marianne Piérard-Franchimont, Claudine J Biomed Biotechnol Review Article In some patients, psoriasis appears refractory to many treatments, particularly when the disease is confined to some specific body regions. In this respect, palmoplantar psoriasis and palmoplantar pustulosis are possibly related conditions in their immunopathomechanisms involving Il-12, IL-23, and Th17. Nail psoriasis and scalp psoriasis are two other particular psoriasis manifestations. Accordingly, ustekinumab was tested in a few of these patients. The present paper is limited to peer-reviewed case reports. Data were not supported by bioinstrumental assessments and controlled trials. Overall, they are indicative of potential efficacy. The cost-effectiveness and the risk-benefit assessments merit further investigations. Hindawi Publishing Corporation 2012 2012-08-13 /pmc/articles/PMC3425983/ /pubmed/22927720 http://dx.doi.org/10.1155/2012/413767 Text en Copyright © 2012 Trinh Hermanns-Lê et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Hermanns-Lê, Trinh
Berardesca, Enzo
Piérard, Gérald E.
Lesuisse, Marianne
Piérard-Franchimont, Claudine
Challenging Regional Psoriasis and Ustekinumab Biotherapy: Impact of the Patterns of Disease
title Challenging Regional Psoriasis and Ustekinumab Biotherapy: Impact of the Patterns of Disease
title_full Challenging Regional Psoriasis and Ustekinumab Biotherapy: Impact of the Patterns of Disease
title_fullStr Challenging Regional Psoriasis and Ustekinumab Biotherapy: Impact of the Patterns of Disease
title_full_unstemmed Challenging Regional Psoriasis and Ustekinumab Biotherapy: Impact of the Patterns of Disease
title_short Challenging Regional Psoriasis and Ustekinumab Biotherapy: Impact of the Patterns of Disease
title_sort challenging regional psoriasis and ustekinumab biotherapy: impact of the patterns of disease
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3425983/
https://www.ncbi.nlm.nih.gov/pubmed/22927720
http://dx.doi.org/10.1155/2012/413767
work_keys_str_mv AT hermannsletrinh challengingregionalpsoriasisandustekinumabbiotherapyimpactofthepatternsofdisease
AT berardescaenzo challengingregionalpsoriasisandustekinumabbiotherapyimpactofthepatternsofdisease
AT pierardgeralde challengingregionalpsoriasisandustekinumabbiotherapyimpactofthepatternsofdisease
AT lesuissemarianne challengingregionalpsoriasisandustekinumabbiotherapyimpactofthepatternsofdisease
AT pierardfranchimontclaudine challengingregionalpsoriasisandustekinumabbiotherapyimpactofthepatternsofdisease

Ejemplares similares