Cargando…

Synthesis and Evaluation of Substituted Chroman-4-one and Chromone Derivatives as Sirtuin 2-Selective Inhibitors

[Image: see text] A series of substituted chromone/chroman-4-one derivatives has been synthesized and evaluated as novel inhibitors of SIRT2, an enzyme involved in aging-related diseases, e.g., neurodegenerative disorders. The analogues were efficiently synthesized in a one-step procedure including...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fridén-Saxin, Maria, Seifert, Tina, Landergren, Marie Rydén, Suuronen, Tiina, Lahtela-Kakkonen, Maija, Jarho, Elina M., Luthman, Kristina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2012
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3426190/ https://www.ncbi.nlm.nih.gov/pubmed/22746324 http://dx.doi.org/10.1021/jm3005288

Ejemplares similares

BET Inhibition Upregulates SIRT1 and Alleviates Inflammatory Responses
por: Kokkola, Tarja, et al.
Publicado: (2015)

Sirtuin functions and modulation: from chemistry to the clinic
por: Carafa, Vincenzo, et al.
Publicado: (2016)

Natural polyphenols as sirtuin 6 modulators
por: Rahnasto-Rilla, Minna, et al.
Publicado: (2018)

Visible-light synthesis of 4-substituted-chroman-2-ones and 2-substituted-chroman-4-ones via doubly decarboxylative Giese reaction
por: Moczulski, Marek, et al.
Publicado: (2021)

3-Bromochroman-4-one
por: Shaikh, Mahidansha M., et al.
Publicado: (2013)

Potent mechanism-based sirtuin-2-selective inhibition by an in situ-generated occupant of the substrate-binding site, “selectivity pocket” and NAD(+)-binding site
por: Mellini, Paolo, et al.
Publicado: (2017)

PE and PET oligomers’ interplay with membrane bilayers
por: Järvenpää, Joni, et al.
Publicado: (2022)

Doubly Decarboxylative Synthesis of 4-(Pyridylmethyl)chroman-2-ones and 2-(Pyridylmethyl)chroman-4-ones under Mild Reaction Conditions †
por: Bojanowski, Jan, et al.
Publicado: (2021)

2-Imidazole as a Substitute for the Electrophilic Group Gives Highly Potent Prolyl Oligopeptidase Inhibitors
por: Pätsi, Henri T., et al.
Publicado: (2021)

SIRT2i_Predictor: A Machine Learning-Based Tool to Facilitate the Discovery of Novel SIRT2 Inhibitors
por: Djokovic, Nemanja, et al.
Publicado: (2023)

3-Benzylidene-6-methoxychroman-4-one
por: Augustine, T., et al.
Publicado: (2008)

7-Methoxy-2-phenylchroman-4-one
por: Piaskowska, Agata, et al.
Publicado: (2013)

Stereochemistry of Chiral 2-Substituted Chromanes: Twist of the Dihydropyran Ring and Specific Optical Rotation
por: Yang, Bei-Bei, et al.
Publicado: (2023)

3-(3-Methoxybenzylidene)chroman-4-one
por: Gopaul, Kaalin, et al.
Publicado: (2012)

6-Hydroxy-7,8-dimethylchroman-2-one
por: Goswami, Shailesh K., et al.
Publicado: (2012)

3-(3,4-Dichlorobenzylidene)chroman-4-one
por: Gopaul, Kaalin, et al.
Publicado: (2012)

New chroman-4-one/thiochroman-4-one derivatives as potential anticancer agents
por: Demirayak, Seref, et al.
Publicado: (2017)

NaH Promoted One-Pot Tandem Reactions of 3-(1-Alkynyl) Chromones to Form 2-Nitrogen-Substituted Xanthones
por: Duan, Wen-Di, et al.
Publicado: (2020)

6-Hydroxy-5,7,8-trimethylchroman-2-one
por: Goswami, Shailesh K., et al.
Publicado: (2011)

6-Chloro-4-(2-phenylethenyl)chroman-2-one
por: Choi, Kwang-Su, et al.
Publicado: (2010)

3-(3,4-Dimethoxybenzyl)chroman-4-one
por: Shalini, S., et al.
Publicado: (2013)

rac-3-(4-Hydroxybenzyl)chroman-4-one
por: Shalini, S., et al.
Publicado: (2013)

Crystal structures of (E)-3-(4-hydroxybenzylidene)chroman-4-one and (E)-3-(3-hydroxybenzylidene)-2-phenylchroman-4-one
por: Suchojad, Kamil, et al.
Publicado: (2019)

3-Nitro-2-phenylchroman
por: Zhao, Pei-Hua, et al.
Publicado: (2012)

(E)-6-Methyl-3-(2-methylbenzylidene)chroman-2-one
por: Vijayakumar, S., et al.
Publicado: (2012)

5-Chloro-6-hydroxy-7,8-dimethylchroman-2-one
por: Cameron, Scott A., et al.
Publicado: (2011)

2-(4-Chlorophenyl)-6-methoxychroman-4-one
por: Jasinski, Jerry P., et al.
Publicado: (2010)

Gold(I)-catalysed one-pot synthesis of chromans using allylic alcohols and phenols
por: Coutant, Eloi, et al.
Publicado: (2013)

(E)-3-(4-Cyclohexyl-3-fluorobenzylidene)chroman-4-one
por: Gopaul, Kaalin, et al.
Publicado: (2012)

7-Methoxy-3-(4-methoxyphenyl)chroman-4-one
por: Peng, Zhi-Yun, et al.
Publicado: (2012)

6-Chloro-3-[(dimethylamino)methylidene]thiochroman-4-one
por: Khan, Ashraf Y., et al.
Publicado: (2013)

Chroman-4-One Derivatives Targeting Pteridine Reductase 1 and Showing Anti-Parasitic Activity
por: Di Pisa, Flavio, et al.
Publicado: (2017)

Synthesis of Chromone-Related Pyrazole Compounds
por: Santos, Clementina M. M., et al.
Publicado: (2017)

Chromone and Flavonoid Alkaloids: Occurrence and Bioactivity
por: Khadem, Shahriar, et al.
Publicado: (2011)

One-Pot Synthesis and Evaluation of Antioxidative Stress and Anticancer Properties of an Active Chromone Derivative
por: Maicheen, Chirattikan, et al.
Publicado: (2023)

New Hybrid Hydrazinyl Thiazole Substituted Chromones: As Potential α-Amylase Inhibitors and Radical (DPPH & ABTS) Scavengers
por: Salar, Uzma, et al.
Publicado: (2017)

3-(4-Hydroxyphenyl)-7-methoxychroman-4-one monohydrate
por: Xiao, Zhu-Ping, et al.
Publicado: (2011)

8-Ethoxy-3-(4-isopropylbenzylidene)-6-methylchroman-4-one
por: Marx, A., et al.
Publicado: (2007)

Searching for new cytotoxic agents based on chromen-4-one and chromane-2,4-dione scaffolds
por: Gaspar, Alexandra, et al.
Publicado: (2019)

Ultrasound-Promoted Greener Synthesis of Novel Trifurcate 3-Substituted-chroman-2,4-dione Derivatives and Their Drug-Likeness Evaluation
por: Liang, Chengyuan, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_h29rttvmmb68oqbgsocov85ai9