Cargando…

Strategies to Prevent Anthracycline-Related Congestive Heart Failure in Survivors of Childhood Cancer

Cardiovascular complications are a leading cause of therapy-related morbidity and mortality in long-term survivors of childhood malignancy. In fact, childhood cancer survivors are at a 15-fold risk of developing CHF compared to age-matched controls. There is a strong dose-dependent association betwe...

Descripción completa

Detalles Bibliográficos
Autores principales: Armenian, Saro H., Gelehrter, Sarah K., Chow, Eric J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3426199/
https://www.ncbi.nlm.nih.gov/pubmed/22928146
http://dx.doi.org/10.1155/2012/713294
_version_ 1782241480798109696
author Armenian, Saro H.
Gelehrter, Sarah K.
Chow, Eric J.
author_facet Armenian, Saro H.
Gelehrter, Sarah K.
Chow, Eric J.
author_sort Armenian, Saro H.
collection PubMed
description Cardiovascular complications are a leading cause of therapy-related morbidity and mortality in long-term survivors of childhood malignancy. In fact, childhood cancer survivors are at a 15-fold risk of developing CHF compared to age-matched controls. There is a strong dose-dependent association between anthracycline exposure and risk of CHF, and the incidence increases with longer followup. Outcome following diagnosis of CHF is generally poor, with overall survival less than 50% at 5 years. The growing number of childhood cancer survivors makes it imperative that strategies be developed to prevent symptomatic heart disease in this vulnerable population. We present here an overview of the current state of knowledge regarding primary, secondary, and tertiary prevention strategies for childhood cancer survivors at high risk for CHF, drawing on lessons learned from prevention studies in nononcology populations as well as from the more limited experience in cancer survivors.
format Online
Article
Text
id pubmed-3426199
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-34261992012-08-27 Strategies to Prevent Anthracycline-Related Congestive Heart Failure in Survivors of Childhood Cancer Armenian, Saro H. Gelehrter, Sarah K. Chow, Eric J. Cardiol Res Pract Review Article Cardiovascular complications are a leading cause of therapy-related morbidity and mortality in long-term survivors of childhood malignancy. In fact, childhood cancer survivors are at a 15-fold risk of developing CHF compared to age-matched controls. There is a strong dose-dependent association between anthracycline exposure and risk of CHF, and the incidence increases with longer followup. Outcome following diagnosis of CHF is generally poor, with overall survival less than 50% at 5 years. The growing number of childhood cancer survivors makes it imperative that strategies be developed to prevent symptomatic heart disease in this vulnerable population. We present here an overview of the current state of knowledge regarding primary, secondary, and tertiary prevention strategies for childhood cancer survivors at high risk for CHF, drawing on lessons learned from prevention studies in nononcology populations as well as from the more limited experience in cancer survivors. Hindawi Publishing Corporation 2012 2012-08-15 /pmc/articles/PMC3426199/ /pubmed/22928146 http://dx.doi.org/10.1155/2012/713294 Text en Copyright © 2012 Saro H. Armenian et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Armenian, Saro H.
Gelehrter, Sarah K.
Chow, Eric J.
Strategies to Prevent Anthracycline-Related Congestive Heart Failure in Survivors of Childhood Cancer
title Strategies to Prevent Anthracycline-Related Congestive Heart Failure in Survivors of Childhood Cancer
title_full Strategies to Prevent Anthracycline-Related Congestive Heart Failure in Survivors of Childhood Cancer
title_fullStr Strategies to Prevent Anthracycline-Related Congestive Heart Failure in Survivors of Childhood Cancer
title_full_unstemmed Strategies to Prevent Anthracycline-Related Congestive Heart Failure in Survivors of Childhood Cancer
title_short Strategies to Prevent Anthracycline-Related Congestive Heart Failure in Survivors of Childhood Cancer
title_sort strategies to prevent anthracycline-related congestive heart failure in survivors of childhood cancer
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3426199/
https://www.ncbi.nlm.nih.gov/pubmed/22928146
http://dx.doi.org/10.1155/2012/713294
work_keys_str_mv AT armeniansaroh strategiestopreventanthracyclinerelatedcongestiveheartfailureinsurvivorsofchildhoodcancer
AT gelehrtersarahk strategiestopreventanthracyclinerelatedcongestiveheartfailureinsurvivorsofchildhoodcancer
AT chowericj strategiestopreventanthracyclinerelatedcongestiveheartfailureinsurvivorsofchildhoodcancer