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The effects of serum lipids on the in vitro activity of lumefantrine and atovaquone against Plasmodium falciparum

BACKGROUND: Lumefantrine and atovaquone are highly lipophilic anti-malarial drugs. As a consequence absorption is increased when the drugs are taken together with a fatty meal, but the free fraction of active drug decreases in the presence of triglyceride-rich plasma lipoproteins. In this study, the...

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Detalles Bibliográficos
Autores principales:	Chotivanich, Kesinee, Mungthin, Mathirut, Ruengweerayuth, Ronnatrai, Udomsangpetch, Rachanee, Dondorp, Arjen M, Singhasivanon, Pratap, Pukrittayakamee, Sasithon, White, Nicholas J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3426466/ https://www.ncbi.nlm.nih.gov/pubmed/22640826 http://dx.doi.org/10.1186/1475-2875-11-177

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