Prognostic value of unrelated atypical serum immunofixation patterns during Multiple Myeloma therapy

Autologous stem cell transplantation (ASCT) is the gold standard therapy for suitable multiple myeloma (MM) patients after induction with high dose therapy. To date, the evidence of a reliable marker of prognosis in these cases remains scarce. Our aim was to evaluate appearance of unrelated atypical...

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Autores principales: Guimarães, Cristina, Bergantim, Rui, Ramalho, Renata, Couto, Nuno, Guimarães, João T, Trigo, Fernanda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3426471/
https://www.ncbi.nlm.nih.gov/pubmed/22734892
http://dx.doi.org/10.1186/1756-8722-5-33
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author Guimarães, Cristina
Bergantim, Rui
Ramalho, Renata
Couto, Nuno
Guimarães, João T
Trigo, Fernanda
author_facet Guimarães, Cristina
Bergantim, Rui
Ramalho, Renata
Couto, Nuno
Guimarães, João T
Trigo, Fernanda
author_sort Guimarães, Cristina
collection PubMed
description Autologous stem cell transplantation (ASCT) is the gold standard therapy for suitable multiple myeloma (MM) patients after induction with high dose therapy. To date, the evidence of a reliable marker of prognosis in these cases remains scarce. Our aim was to evaluate appearance of unrelated atypical serum immunofixation patterns (ASIPs) as a marker of prognosis in MM patients submitted to ASCT. We retrospectively analysed data from 65 patients. Interestingly, we observed that presence of ASIPs was associated with longer progression-free survival and longer overall survival. Our results suggested that presence of ASIPs could be a novel marker of good prognosis in MM patients submitted to ASCT.
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spelling pubmed-34264712012-08-24 Prognostic value of unrelated atypical serum immunofixation patterns during Multiple Myeloma therapy Guimarães, Cristina Bergantim, Rui Ramalho, Renata Couto, Nuno Guimarães, João T Trigo, Fernanda J Hematol Oncol Letter to the Editor Autologous stem cell transplantation (ASCT) is the gold standard therapy for suitable multiple myeloma (MM) patients after induction with high dose therapy. To date, the evidence of a reliable marker of prognosis in these cases remains scarce. Our aim was to evaluate appearance of unrelated atypical serum immunofixation patterns (ASIPs) as a marker of prognosis in MM patients submitted to ASCT. We retrospectively analysed data from 65 patients. Interestingly, we observed that presence of ASIPs was associated with longer progression-free survival and longer overall survival. Our results suggested that presence of ASIPs could be a novel marker of good prognosis in MM patients submitted to ASCT. BioMed Central 2012-06-26 /pmc/articles/PMC3426471/ /pubmed/22734892 http://dx.doi.org/10.1186/1756-8722-5-33 Text en Copyright ©2012 Guimaraes et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Letter to the Editor
Guimarães, Cristina
Bergantim, Rui
Ramalho, Renata
Couto, Nuno
Guimarães, João T
Trigo, Fernanda
Prognostic value of unrelated atypical serum immunofixation patterns during Multiple Myeloma therapy
title Prognostic value of unrelated atypical serum immunofixation patterns during Multiple Myeloma therapy
title_full Prognostic value of unrelated atypical serum immunofixation patterns during Multiple Myeloma therapy
title_fullStr Prognostic value of unrelated atypical serum immunofixation patterns during Multiple Myeloma therapy
title_full_unstemmed Prognostic value of unrelated atypical serum immunofixation patterns during Multiple Myeloma therapy
title_short Prognostic value of unrelated atypical serum immunofixation patterns during Multiple Myeloma therapy
title_sort prognostic value of unrelated atypical serum immunofixation patterns during multiple myeloma therapy
topic Letter to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3426471/
https://www.ncbi.nlm.nih.gov/pubmed/22734892
http://dx.doi.org/10.1186/1756-8722-5-33
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