The Proteins PDIP3 and ZC11A Associate with the Human TREX Complex in an ATP-Dependent Manner and Function in mRNA Export

The conserved TREX complex, which contains UAP56, Aly, CIP29, and the multi-subunit THO complex, functions in mRNA export. Recently, several putative new components of the human TREX complex were identified by mass spectrometry. Here, we investigated the function of two of these, PDIP3 and ZC11A. Ou...

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Detalles Bibliográficos
Autores principales: Folco, Eric G., Lee, Chung-Sheng, Dufu, Kobina, Yamazaki, Tomohiro, Reed, Robin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3426524/
https://www.ncbi.nlm.nih.gov/pubmed/22928037
http://dx.doi.org/10.1371/journal.pone.0043804
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author Folco, Eric G.
Lee, Chung-Sheng
Dufu, Kobina
Yamazaki, Tomohiro
Reed, Robin
author_facet Folco, Eric G.
Lee, Chung-Sheng
Dufu, Kobina
Yamazaki, Tomohiro
Reed, Robin
author_sort Folco, Eric G.
collection PubMed
description The conserved TREX complex, which contains UAP56, Aly, CIP29, and the multi-subunit THO complex, functions in mRNA export. Recently, several putative new components of the human TREX complex were identified by mass spectrometry. Here, we investigated the function of two of these, PDIP3 and ZC11A. Our data indicate that both of these proteins are components of a common TREX complex and function in mRNA export. Recently, we found that both CIP29 and Aly associate with the DEAD box helicase UAP56 and with the TREX complex in an ATP-dependent manner. We now show that this is also the case for PDIP3 and ZC11A. Thus, together with previous work, our data indicate that the TREX complex participates in multiple ATP-dependent interactions.
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spelling pubmed-34265242012-08-27 The Proteins PDIP3 and ZC11A Associate with the Human TREX Complex in an ATP-Dependent Manner and Function in mRNA Export Folco, Eric G. Lee, Chung-Sheng Dufu, Kobina Yamazaki, Tomohiro Reed, Robin PLoS One Research Article The conserved TREX complex, which contains UAP56, Aly, CIP29, and the multi-subunit THO complex, functions in mRNA export. Recently, several putative new components of the human TREX complex were identified by mass spectrometry. Here, we investigated the function of two of these, PDIP3 and ZC11A. Our data indicate that both of these proteins are components of a common TREX complex and function in mRNA export. Recently, we found that both CIP29 and Aly associate with the DEAD box helicase UAP56 and with the TREX complex in an ATP-dependent manner. We now show that this is also the case for PDIP3 and ZC11A. Thus, together with previous work, our data indicate that the TREX complex participates in multiple ATP-dependent interactions. Public Library of Science 2012-08-23 /pmc/articles/PMC3426524/ /pubmed/22928037 http://dx.doi.org/10.1371/journal.pone.0043804 Text en © 2012 Folco et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Folco, Eric G.
Lee, Chung-Sheng
Dufu, Kobina
Yamazaki, Tomohiro
Reed, Robin
The Proteins PDIP3 and ZC11A Associate with the Human TREX Complex in an ATP-Dependent Manner and Function in mRNA Export
title The Proteins PDIP3 and ZC11A Associate with the Human TREX Complex in an ATP-Dependent Manner and Function in mRNA Export
title_full The Proteins PDIP3 and ZC11A Associate with the Human TREX Complex in an ATP-Dependent Manner and Function in mRNA Export
title_fullStr The Proteins PDIP3 and ZC11A Associate with the Human TREX Complex in an ATP-Dependent Manner and Function in mRNA Export
title_full_unstemmed The Proteins PDIP3 and ZC11A Associate with the Human TREX Complex in an ATP-Dependent Manner and Function in mRNA Export
title_short The Proteins PDIP3 and ZC11A Associate with the Human TREX Complex in an ATP-Dependent Manner and Function in mRNA Export
title_sort proteins pdip3 and zc11a associate with the human trex complex in an atp-dependent manner and function in mrna export
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3426524/
https://www.ncbi.nlm.nih.gov/pubmed/22928037
http://dx.doi.org/10.1371/journal.pone.0043804
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