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A Unique Bivalent Binding and Inhibition Mechanism by the Yatapoxvirus Interleukin 18 Binding Protein

Interleukin 18 (IL18) is a cytokine that plays an important role in inflammation as well as host defense against microbes. Mammals encode a soluble inhibitor of IL18 termed IL18 binding protein (IL18BP) that modulates IL18 activity through a negative feedback mechanism. Many poxviruses encode homolo...

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Detalles Bibliográficos
Autores principales:	Krumm, Brian, Meng, Xiangzhi, Wang, Zhixin, Xiang, Yan, Deng, Junpeng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3426546/ https://www.ncbi.nlm.nih.gov/pubmed/22927815 http://dx.doi.org/10.1371/journal.ppat.1002876

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