Chemical Genetics Reveals a Specific Requirement for Cdk2 Activity in the DNA Damage Response and Identifies Nbs1 as a Cdk2 Substrate in Human Cells

The cyclin-dependent kinases (CDKs) that promote cell-cycle progression are targets for negative regulation by signals from damaged or unreplicated DNA, but also play active roles in response to DNA lesions. The requirement for activity in the face of DNA damage implies that there are mechanisms to...

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Detalles Bibliográficos
Autores principales: Wohlbold, Lara, Merrick, Karl A., De, Saurav, Amat, Ramon, Kim, Jun Hyun, Larochelle, Stéphane, Allen, Jasmina J., Zhang, Chao, Shokat, Kevan M., Petrini, John H. J., Fisher, Robert P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3426557/
https://www.ncbi.nlm.nih.gov/pubmed/22927831
http://dx.doi.org/10.1371/journal.pgen.1002935

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