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Prediction of Mutational Tolerance in HIV-1 Protease and Reverse Transcriptase Using Flexible Backbone Protein Design

Predicting which mutations proteins tolerate while maintaining their structure and function has important applications for modeling fundamental properties of proteins and their evolution; it also drives progress in protein design. Here we develop a computational model to predict the tolerated sequen...

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Detalles Bibliográficos
Autores principales:	Humphris-Narayanan, Elisabeth, Akiva, Eyal, Varela, Rocco, Ó Conchúir, Shane, Kortemme, Tanja
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3426558/ https://www.ncbi.nlm.nih.gov/pubmed/22927804 http://dx.doi.org/10.1371/journal.pcbi.1002639

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