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Anti-N-methyl-D-aspartate receptor encephalitis presenting with acute psychosis in a preteenage girl: a case report

INTRODUCTION: Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis is a rare, newly defined autoimmune clinical entity that presents with atypical clinical manifestations. Most patients with anti-N-methyl-D-aspartate receptor encephalitis develop a progressive illness from psychosis into a s...

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Autores principales: Maggina, Paraskevi, Mavrikou, Mersini, Karagianni, Stavroula, Skevaki, Chrysanthi L, Triantafyllidou, Antigoni, Voudris, Constantinos, Katsarou, Eustathia, Stamogiannou, Lela, Mastroyianni, Sotiria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3427036/
https://www.ncbi.nlm.nih.gov/pubmed/22846610
http://dx.doi.org/10.1186/1752-1947-6-224
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author Maggina, Paraskevi
Mavrikou, Mersini
Karagianni, Stavroula
Skevaki, Chrysanthi L
Triantafyllidou, Antigoni
Voudris, Constantinos
Katsarou, Eustathia
Stamogiannou, Lela
Mastroyianni, Sotiria
author_facet Maggina, Paraskevi
Mavrikou, Mersini
Karagianni, Stavroula
Skevaki, Chrysanthi L
Triantafyllidou, Antigoni
Voudris, Constantinos
Katsarou, Eustathia
Stamogiannou, Lela
Mastroyianni, Sotiria
author_sort Maggina, Paraskevi
collection PubMed
description INTRODUCTION: Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis is a rare, newly defined autoimmune clinical entity that presents with atypical clinical manifestations. Most patients with anti-N-methyl-D-aspartate receptor encephalitis develop a progressive illness from psychosis into a state of unresponsiveness, with catatonic features often associated with abnormal movements and autonomic instability. This is the first report of anti-N-methyl-D-aspartate receptor encephalitis in a Greek pediatric hospital. CASE PRESENTATION: An 11-year-old Greek girl presented with clinical manifestations of acute psychosis. The differential diagnosis included viral encephalitis. The presence of a tumor usually an ovarian teratoma, a common clinical finding in many patients, was excluded. Early diagnosis and prompt immunotherapy resulted in full recovery up to one year after the initial diagnosis. CONCLUSION: Acute psychosis is a rare psychiatric presentation in children, diagnosed only after possible organic syndromes that mimic acute psychosis are excluded, including anti-N-methyl-D-aspartate receptor receptor encephalitis. Pediatricians, neurologists and psychiatrists should consider this rare clinical syndrome, in order to make an early diagnosis and instigate appropriate treatment to maximize neurological recovery.
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spelling pubmed-34270362012-08-25 Anti-N-methyl-D-aspartate receptor encephalitis presenting with acute psychosis in a preteenage girl: a case report Maggina, Paraskevi Mavrikou, Mersini Karagianni, Stavroula Skevaki, Chrysanthi L Triantafyllidou, Antigoni Voudris, Constantinos Katsarou, Eustathia Stamogiannou, Lela Mastroyianni, Sotiria J Med Case Rep Case Report INTRODUCTION: Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis is a rare, newly defined autoimmune clinical entity that presents with atypical clinical manifestations. Most patients with anti-N-methyl-D-aspartate receptor encephalitis develop a progressive illness from psychosis into a state of unresponsiveness, with catatonic features often associated with abnormal movements and autonomic instability. This is the first report of anti-N-methyl-D-aspartate receptor encephalitis in a Greek pediatric hospital. CASE PRESENTATION: An 11-year-old Greek girl presented with clinical manifestations of acute psychosis. The differential diagnosis included viral encephalitis. The presence of a tumor usually an ovarian teratoma, a common clinical finding in many patients, was excluded. Early diagnosis and prompt immunotherapy resulted in full recovery up to one year after the initial diagnosis. CONCLUSION: Acute psychosis is a rare psychiatric presentation in children, diagnosed only after possible organic syndromes that mimic acute psychosis are excluded, including anti-N-methyl-D-aspartate receptor receptor encephalitis. Pediatricians, neurologists and psychiatrists should consider this rare clinical syndrome, in order to make an early diagnosis and instigate appropriate treatment to maximize neurological recovery. BioMed Central 2012-07-30 /pmc/articles/PMC3427036/ /pubmed/22846610 http://dx.doi.org/10.1186/1752-1947-6-224 Text en Copyright ©2012 Maggina et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Maggina, Paraskevi
Mavrikou, Mersini
Karagianni, Stavroula
Skevaki, Chrysanthi L
Triantafyllidou, Antigoni
Voudris, Constantinos
Katsarou, Eustathia
Stamogiannou, Lela
Mastroyianni, Sotiria
Anti-N-methyl-D-aspartate receptor encephalitis presenting with acute psychosis in a preteenage girl: a case report
title Anti-N-methyl-D-aspartate receptor encephalitis presenting with acute psychosis in a preteenage girl: a case report
title_full Anti-N-methyl-D-aspartate receptor encephalitis presenting with acute psychosis in a preteenage girl: a case report
title_fullStr Anti-N-methyl-D-aspartate receptor encephalitis presenting with acute psychosis in a preteenage girl: a case report
title_full_unstemmed Anti-N-methyl-D-aspartate receptor encephalitis presenting with acute psychosis in a preteenage girl: a case report
title_short Anti-N-methyl-D-aspartate receptor encephalitis presenting with acute psychosis in a preteenage girl: a case report
title_sort anti-n-methyl-d-aspartate receptor encephalitis presenting with acute psychosis in a preteenage girl: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3427036/
https://www.ncbi.nlm.nih.gov/pubmed/22846610
http://dx.doi.org/10.1186/1752-1947-6-224
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