Pseudotyped AAV Vector-Mediated Gene Transfer in a Human Fetal Trachea Xenograft Model: Implications for In Utero Gene Therapy for Cystic Fibrosis

BACKGROUND: Lung disease including airway infection and inflammation currently causes the majority of morbidities and mortalities associated with cystic fibrosis (CF), making the airway epithelium and the submucosal glands (SMG) novel target cells for gene therapy in CF. These target cells are relat...

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Detalles Bibliográficos
Autores principales: Keswani, Sundeep G., Balaji, Swathi, Le, Louis, Leung, Alice, Katz, Anna B., Lim, Foong-Yen, Habli, Mounira, Jones, Helen N., Wilson, James M., Crombleholme, Timothy M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3427158/
https://www.ncbi.nlm.nih.gov/pubmed/22937069
http://dx.doi.org/10.1371/journal.pone.0043633

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