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Microbes-induced EMT at the crossroad of inflammation and cancer
It is noteworthy that bacterial or viral infections, and the resulting chronic inflammation, have been shown to predispose individuals to certain types of cancer. Remarkably, these microbes upregulated some transcription factors involved in the regulation of the epithelial to mesenchymal transition,...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Landes Bioscience
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3427211/ https://www.ncbi.nlm.nih.gov/pubmed/22572828 http://dx.doi.org/10.4161/gmic.20288 |
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author | Hofman, Paul Vouret-Craviari, Valérie |
author_facet | Hofman, Paul Vouret-Craviari, Valérie |
author_sort | Hofman, Paul |
collection | PubMed |
description | It is noteworthy that bacterial or viral infections, and the resulting chronic inflammation, have been shown to predispose individuals to certain types of cancer. Remarkably, these microbes upregulated some transcription factors involved in the regulation of the epithelial to mesenchymal transition, referred herein as EMT. EMT is a cellular process that consists in the conversion of epithelial cell phenotype to a mesenchymal phenotype. Under physiological conditions EMT is clearly important for embryogenesis, organ development, wound repair and tissue remodeling. However, EMT may also be activated under pathologic conditions, more particularly in carcinogenesis and metastatic progression. In this review, we make a parallel between microbes- and growth factors-induced transcription factors. A unifying EMT model then emerges that may help in understanding the development of microbial pathogenesis and in defining new potential future therapeutic strategy in treating diseases linked to infections. |
format | Online Article Text |
id | pubmed-3427211 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Landes Bioscience |
record_format | MEDLINE/PubMed |
spelling | pubmed-34272112012-08-27 Microbes-induced EMT at the crossroad of inflammation and cancer Hofman, Paul Vouret-Craviari, Valérie Gut Microbes Review It is noteworthy that bacterial or viral infections, and the resulting chronic inflammation, have been shown to predispose individuals to certain types of cancer. Remarkably, these microbes upregulated some transcription factors involved in the regulation of the epithelial to mesenchymal transition, referred herein as EMT. EMT is a cellular process that consists in the conversion of epithelial cell phenotype to a mesenchymal phenotype. Under physiological conditions EMT is clearly important for embryogenesis, organ development, wound repair and tissue remodeling. However, EMT may also be activated under pathologic conditions, more particularly in carcinogenesis and metastatic progression. In this review, we make a parallel between microbes- and growth factors-induced transcription factors. A unifying EMT model then emerges that may help in understanding the development of microbial pathogenesis and in defining new potential future therapeutic strategy in treating diseases linked to infections. Landes Bioscience 2012-05-01 /pmc/articles/PMC3427211/ /pubmed/22572828 http://dx.doi.org/10.4161/gmic.20288 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. |
spellingShingle | Review Hofman, Paul Vouret-Craviari, Valérie Microbes-induced EMT at the crossroad of inflammation and cancer |
title | Microbes-induced EMT at the crossroad of inflammation and cancer |
title_full | Microbes-induced EMT at the crossroad of inflammation and cancer |
title_fullStr | Microbes-induced EMT at the crossroad of inflammation and cancer |
title_full_unstemmed | Microbes-induced EMT at the crossroad of inflammation and cancer |
title_short | Microbes-induced EMT at the crossroad of inflammation and cancer |
title_sort | microbes-induced emt at the crossroad of inflammation and cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3427211/ https://www.ncbi.nlm.nih.gov/pubmed/22572828 http://dx.doi.org/10.4161/gmic.20288 |
work_keys_str_mv | AT hofmanpaul microbesinducedemtatthecrossroadofinflammationandcancer AT vouretcraviarivalerie microbesinducedemtatthecrossroadofinflammationandcancer |