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Adherens junction function and regulation during zebrafish gastrulation

The adherens junction (AJ) comprises multi-protein complexes required for cell-cell adhesion in embryonic development and adult tissue homeostasis. Mutations in key proteins and mis-regulation of AJ adhesive properties can lead to pathologies such as cancer. In recent years, the zebrafish has become...

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Detalles Bibliográficos
Autores principales: Schepis, Antonino, Nelson, W. James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3427231/
https://www.ncbi.nlm.nih.gov/pubmed/22568981
http://dx.doi.org/10.4161/cam.20583
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author Schepis, Antonino
Nelson, W. James
author_facet Schepis, Antonino
Nelson, W. James
author_sort Schepis, Antonino
collection PubMed
description The adherens junction (AJ) comprises multi-protein complexes required for cell-cell adhesion in embryonic development and adult tissue homeostasis. Mutations in key proteins and mis-regulation of AJ adhesive properties can lead to pathologies such as cancer. In recent years, the zebrafish has become an excellent model organism to integrate cell biology in the context of a multicellular organization. The combination of classical genetic approaches with new tools for live imaging and biophysical approaches has revealed new aspects of AJ biology, particularly during zebrafish gastrulation. These studies have resulted in progress in understanding the relationship between cell-cell adhesion, cell migration and plasma membrane blebbing.
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spelling pubmed-34272312012-08-27 Adherens junction function and regulation during zebrafish gastrulation Schepis, Antonino Nelson, W. James Cell Adh Migr Commentary The adherens junction (AJ) comprises multi-protein complexes required for cell-cell adhesion in embryonic development and adult tissue homeostasis. Mutations in key proteins and mis-regulation of AJ adhesive properties can lead to pathologies such as cancer. In recent years, the zebrafish has become an excellent model organism to integrate cell biology in the context of a multicellular organization. The combination of classical genetic approaches with new tools for live imaging and biophysical approaches has revealed new aspects of AJ biology, particularly during zebrafish gastrulation. These studies have resulted in progress in understanding the relationship between cell-cell adhesion, cell migration and plasma membrane blebbing. Landes Bioscience 2012-05-01 /pmc/articles/PMC3427231/ /pubmed/22568981 http://dx.doi.org/10.4161/cam.20583 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Commentary
Schepis, Antonino
Nelson, W. James
Adherens junction function and regulation during zebrafish gastrulation
title Adherens junction function and regulation during zebrafish gastrulation
title_full Adherens junction function and regulation during zebrafish gastrulation
title_fullStr Adherens junction function and regulation during zebrafish gastrulation
title_full_unstemmed Adherens junction function and regulation during zebrafish gastrulation
title_short Adherens junction function and regulation during zebrafish gastrulation
title_sort adherens junction function and regulation during zebrafish gastrulation
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3427231/
https://www.ncbi.nlm.nih.gov/pubmed/22568981
http://dx.doi.org/10.4161/cam.20583
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