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Methylation changes at NR3C1 in newborns associate with maternal prenatal stress exposure and newborn birth weight

Early life experiences, including those in utero, have been linked to increased risk for adult-onset chronic disease. The underlying assumption is that there is a critical period of developmental plasticity in utero when selection of the fetal phenotype that is best adapted to the intrauterine envir...

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Detalles Bibliográficos
Autores principales: Mulligan, Connie, D'Errico, Nicole, Stees, Jared, Hughes, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3427280/
https://www.ncbi.nlm.nih.gov/pubmed/22810058
http://dx.doi.org/10.4161/epi.21180
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author Mulligan, Connie
D'Errico, Nicole
Stees, Jared
Hughes, David
author_facet Mulligan, Connie
D'Errico, Nicole
Stees, Jared
Hughes, David
author_sort Mulligan, Connie
collection PubMed
description Early life experiences, including those in utero, have been linked to increased risk for adult-onset chronic disease. The underlying assumption is that there is a critical period of developmental plasticity in utero when selection of the fetal phenotype that is best adapted to the intrauterine environment occurs. The current study is the first to test the idea that extreme maternal psychosocial stressors, as observed in the Democratic Republic of Congo, may modify locus-specific epigenetic marks in the newborn resulting in altered health outcomes. Here we show a significant correlation between culturally relevant measures of maternal prenatal stress, newborn birth weight and newborn methylation in the promoter of the glucocorticoid receptor NR3C1. Increased methylation may constrain plasticity in subsequent gene expression and restrict the range of stress adaptation responses possible in affected individuals, thus increasing their risk for adult-onset diseases.
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spelling pubmed-34272802012-08-27 Methylation changes at NR3C1 in newborns associate with maternal prenatal stress exposure and newborn birth weight Mulligan, Connie D'Errico, Nicole Stees, Jared Hughes, David Epigenetics Brief Report Early life experiences, including those in utero, have been linked to increased risk for adult-onset chronic disease. The underlying assumption is that there is a critical period of developmental plasticity in utero when selection of the fetal phenotype that is best adapted to the intrauterine environment occurs. The current study is the first to test the idea that extreme maternal psychosocial stressors, as observed in the Democratic Republic of Congo, may modify locus-specific epigenetic marks in the newborn resulting in altered health outcomes. Here we show a significant correlation between culturally relevant measures of maternal prenatal stress, newborn birth weight and newborn methylation in the promoter of the glucocorticoid receptor NR3C1. Increased methylation may constrain plasticity in subsequent gene expression and restrict the range of stress adaptation responses possible in affected individuals, thus increasing their risk for adult-onset diseases. Landes Bioscience 2012-08-01 /pmc/articles/PMC3427280/ /pubmed/22810058 http://dx.doi.org/10.4161/epi.21180 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Brief Report
Mulligan, Connie
D'Errico, Nicole
Stees, Jared
Hughes, David
Methylation changes at NR3C1 in newborns associate with maternal prenatal stress exposure and newborn birth weight
title Methylation changes at NR3C1 in newborns associate with maternal prenatal stress exposure and newborn birth weight
title_full Methylation changes at NR3C1 in newborns associate with maternal prenatal stress exposure and newborn birth weight
title_fullStr Methylation changes at NR3C1 in newborns associate with maternal prenatal stress exposure and newborn birth weight
title_full_unstemmed Methylation changes at NR3C1 in newborns associate with maternal prenatal stress exposure and newborn birth weight
title_short Methylation changes at NR3C1 in newborns associate with maternal prenatal stress exposure and newborn birth weight
title_sort methylation changes at nr3c1 in newborns associate with maternal prenatal stress exposure and newborn birth weight
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3427280/
https://www.ncbi.nlm.nih.gov/pubmed/22810058
http://dx.doi.org/10.4161/epi.21180
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