Cargando…
Methylation changes at NR3C1 in newborns associate with maternal prenatal stress exposure and newborn birth weight
Early life experiences, including those in utero, have been linked to increased risk for adult-onset chronic disease. The underlying assumption is that there is a critical period of developmental plasticity in utero when selection of the fetal phenotype that is best adapted to the intrauterine envir...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Landes Bioscience
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3427280/ https://www.ncbi.nlm.nih.gov/pubmed/22810058 http://dx.doi.org/10.4161/epi.21180 |
_version_ | 1782241592104452096 |
---|---|
author | Mulligan, Connie D'Errico, Nicole Stees, Jared Hughes, David |
author_facet | Mulligan, Connie D'Errico, Nicole Stees, Jared Hughes, David |
author_sort | Mulligan, Connie |
collection | PubMed |
description | Early life experiences, including those in utero, have been linked to increased risk for adult-onset chronic disease. The underlying assumption is that there is a critical period of developmental plasticity in utero when selection of the fetal phenotype that is best adapted to the intrauterine environment occurs. The current study is the first to test the idea that extreme maternal psychosocial stressors, as observed in the Democratic Republic of Congo, may modify locus-specific epigenetic marks in the newborn resulting in altered health outcomes. Here we show a significant correlation between culturally relevant measures of maternal prenatal stress, newborn birth weight and newborn methylation in the promoter of the glucocorticoid receptor NR3C1. Increased methylation may constrain plasticity in subsequent gene expression and restrict the range of stress adaptation responses possible in affected individuals, thus increasing their risk for adult-onset diseases. |
format | Online Article Text |
id | pubmed-3427280 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Landes Bioscience |
record_format | MEDLINE/PubMed |
spelling | pubmed-34272802012-08-27 Methylation changes at NR3C1 in newborns associate with maternal prenatal stress exposure and newborn birth weight Mulligan, Connie D'Errico, Nicole Stees, Jared Hughes, David Epigenetics Brief Report Early life experiences, including those in utero, have been linked to increased risk for adult-onset chronic disease. The underlying assumption is that there is a critical period of developmental plasticity in utero when selection of the fetal phenotype that is best adapted to the intrauterine environment occurs. The current study is the first to test the idea that extreme maternal psychosocial stressors, as observed in the Democratic Republic of Congo, may modify locus-specific epigenetic marks in the newborn resulting in altered health outcomes. Here we show a significant correlation between culturally relevant measures of maternal prenatal stress, newborn birth weight and newborn methylation in the promoter of the glucocorticoid receptor NR3C1. Increased methylation may constrain plasticity in subsequent gene expression and restrict the range of stress adaptation responses possible in affected individuals, thus increasing their risk for adult-onset diseases. Landes Bioscience 2012-08-01 /pmc/articles/PMC3427280/ /pubmed/22810058 http://dx.doi.org/10.4161/epi.21180 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. |
spellingShingle | Brief Report Mulligan, Connie D'Errico, Nicole Stees, Jared Hughes, David Methylation changes at NR3C1 in newborns associate with maternal prenatal stress exposure and newborn birth weight |
title | Methylation changes at NR3C1 in newborns associate with maternal prenatal stress exposure and newborn birth weight |
title_full | Methylation changes at NR3C1 in newborns associate with maternal prenatal stress exposure and newborn birth weight |
title_fullStr | Methylation changes at NR3C1 in newborns associate with maternal prenatal stress exposure and newborn birth weight |
title_full_unstemmed | Methylation changes at NR3C1 in newborns associate with maternal prenatal stress exposure and newborn birth weight |
title_short | Methylation changes at NR3C1 in newborns associate with maternal prenatal stress exposure and newborn birth weight |
title_sort | methylation changes at nr3c1 in newborns associate with maternal prenatal stress exposure and newborn birth weight |
topic | Brief Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3427280/ https://www.ncbi.nlm.nih.gov/pubmed/22810058 http://dx.doi.org/10.4161/epi.21180 |
work_keys_str_mv | AT mulliganconnie methylationchangesatnr3c1innewbornsassociatewithmaternalprenatalstressexposureandnewbornbirthweight AT derriconicole methylationchangesatnr3c1innewbornsassociatewithmaternalprenatalstressexposureandnewbornbirthweight AT steesjared methylationchangesatnr3c1innewbornsassociatewithmaternalprenatalstressexposureandnewbornbirthweight AT hughesdavid methylationchangesatnr3c1innewbornsassociatewithmaternalprenatalstressexposureandnewbornbirthweight |