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Pretreatment dietary intake is associated with tumor suppressor DNA methylation in head and neck squamous cell carcinomas

Diet is associated with cancer prognosis, including head and neck cancer (HNC), and has been hypothesized to influence epigenetic state by determining the availability of functional groups involved in the modification of DNA and histone proteins. The goal of this study was to describe the associatio...

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Autores principales: Colacino, Justin A., Arthur, Anna E., Dolinoy, Dana C., Sartor, Maureen A., Duffy, Sonia A., Chepeha, Douglas B., Bradford, Carol R., Walline, Heather M., McHugh, Jonathan B., D'Silva, Nisha, Carey, Thomas E., Wolf, Gregory T., Taylor, Jeremy M.G., Peterson, Karen E., Rozek, Laura S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3427284/
https://www.ncbi.nlm.nih.gov/pubmed/22722388
http://dx.doi.org/10.4161/epi.21038
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author Colacino, Justin A.
Arthur, Anna E.
Dolinoy, Dana C.
Sartor, Maureen A.
Duffy, Sonia A.
Chepeha, Douglas B.
Bradford, Carol R.
Walline, Heather M.
McHugh, Jonathan B.
D'Silva, Nisha
Carey, Thomas E.
Wolf, Gregory T.
Taylor, Jeremy M.G.
Peterson, Karen E.
Rozek, Laura S.
author_facet Colacino, Justin A.
Arthur, Anna E.
Dolinoy, Dana C.
Sartor, Maureen A.
Duffy, Sonia A.
Chepeha, Douglas B.
Bradford, Carol R.
Walline, Heather M.
McHugh, Jonathan B.
D'Silva, Nisha
Carey, Thomas E.
Wolf, Gregory T.
Taylor, Jeremy M.G.
Peterson, Karen E.
Rozek, Laura S.
author_sort Colacino, Justin A.
collection PubMed
description Diet is associated with cancer prognosis, including head and neck cancer (HNC), and has been hypothesized to influence epigenetic state by determining the availability of functional groups involved in the modification of DNA and histone proteins. The goal of this study was to describe the association between pretreatment diet and HNC tumor DNA methylation. Information on usual pretreatment food and nutrient intake was estimated via food frequency questionnaire (FFQ) on 49 HNC cases. Tumor DNA methylation patterns were assessed using the Illumina Goldengate Methylation Cancer Panel. First, a methylation score, the sum of individual hypermethylated tumor suppressor associated CpG sites, was calculated and associated with dietary intake of micronutrients involved in one-carbon metabolism and antioxidant activity, and food groups abundant in these nutrients. Second, gene specific analyses using linear modeling with empirical Bayesian variance estimation were conducted to identify if methylation at individual CpG sites was associated with diet. All models were controlled for age, sex, smoking, alcohol and HPV status. Individuals reporting in the highest quartile of folate, vitamin B12 and vitamin A intake, compared with those in the lowest quartile, showed significantly less tumor suppressor gene methylation, as did patients reporting the highest cruciferous vegetable intake. Gene specific analyses identified differential associations between DNA methylation and vitamin B12 and vitamin A intake when stratifying by HPV status. These preliminary results suggest that intake of folate, vitamin A and vitamin B12 may be associated with the tumor DNA methylation profile in HNC and enhance tumor suppression.
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spelling pubmed-34272842012-08-27 Pretreatment dietary intake is associated with tumor suppressor DNA methylation in head and neck squamous cell carcinomas Colacino, Justin A. Arthur, Anna E. Dolinoy, Dana C. Sartor, Maureen A. Duffy, Sonia A. Chepeha, Douglas B. Bradford, Carol R. Walline, Heather M. McHugh, Jonathan B. D'Silva, Nisha Carey, Thomas E. Wolf, Gregory T. Taylor, Jeremy M.G. Peterson, Karen E. Rozek, Laura S. Epigenetics Research Paper Diet is associated with cancer prognosis, including head and neck cancer (HNC), and has been hypothesized to influence epigenetic state by determining the availability of functional groups involved in the modification of DNA and histone proteins. The goal of this study was to describe the association between pretreatment diet and HNC tumor DNA methylation. Information on usual pretreatment food and nutrient intake was estimated via food frequency questionnaire (FFQ) on 49 HNC cases. Tumor DNA methylation patterns were assessed using the Illumina Goldengate Methylation Cancer Panel. First, a methylation score, the sum of individual hypermethylated tumor suppressor associated CpG sites, was calculated and associated with dietary intake of micronutrients involved in one-carbon metabolism and antioxidant activity, and food groups abundant in these nutrients. Second, gene specific analyses using linear modeling with empirical Bayesian variance estimation were conducted to identify if methylation at individual CpG sites was associated with diet. All models were controlled for age, sex, smoking, alcohol and HPV status. Individuals reporting in the highest quartile of folate, vitamin B12 and vitamin A intake, compared with those in the lowest quartile, showed significantly less tumor suppressor gene methylation, as did patients reporting the highest cruciferous vegetable intake. Gene specific analyses identified differential associations between DNA methylation and vitamin B12 and vitamin A intake when stratifying by HPV status. These preliminary results suggest that intake of folate, vitamin A and vitamin B12 may be associated with the tumor DNA methylation profile in HNC and enhance tumor suppression. Landes Bioscience 2012-08-01 /pmc/articles/PMC3427284/ /pubmed/22722388 http://dx.doi.org/10.4161/epi.21038 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Research Paper
Colacino, Justin A.
Arthur, Anna E.
Dolinoy, Dana C.
Sartor, Maureen A.
Duffy, Sonia A.
Chepeha, Douglas B.
Bradford, Carol R.
Walline, Heather M.
McHugh, Jonathan B.
D'Silva, Nisha
Carey, Thomas E.
Wolf, Gregory T.
Taylor, Jeremy M.G.
Peterson, Karen E.
Rozek, Laura S.
Pretreatment dietary intake is associated with tumor suppressor DNA methylation in head and neck squamous cell carcinomas
title Pretreatment dietary intake is associated with tumor suppressor DNA methylation in head and neck squamous cell carcinomas
title_full Pretreatment dietary intake is associated with tumor suppressor DNA methylation in head and neck squamous cell carcinomas
title_fullStr Pretreatment dietary intake is associated with tumor suppressor DNA methylation in head and neck squamous cell carcinomas
title_full_unstemmed Pretreatment dietary intake is associated with tumor suppressor DNA methylation in head and neck squamous cell carcinomas
title_short Pretreatment dietary intake is associated with tumor suppressor DNA methylation in head and neck squamous cell carcinomas
title_sort pretreatment dietary intake is associated with tumor suppressor dna methylation in head and neck squamous cell carcinomas
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3427284/
https://www.ncbi.nlm.nih.gov/pubmed/22722388
http://dx.doi.org/10.4161/epi.21038
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