Screen Anti-influenza Lead Compounds That Target the PA(C) Subunit of H5N1 Viral RNA Polymerase

The avian influenza (H5N1) viral RNA polymerase protein PA(C) was used as a target to screen nine chlorogenic acid derivatives for their polymerase inhibitor activity. Among them, seven compounds were PA(C) ligands, and four inhibited influenza RNA polymerase activity. These results aid in the desig...

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Detalles Bibliográficos
Autores principales: Li, Lin, Chang, Shenghai, Xiang, Junfeng, Li, Qian, Liang, Huanhuan, Tang, Yalin, Liu, Yingfang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3427309/
https://www.ncbi.nlm.nih.gov/pubmed/22936968
http://dx.doi.org/10.1371/journal.pone.0035234
Descripción
Sumario:The avian influenza (H5N1) viral RNA polymerase protein PA(C) was used as a target to screen nine chlorogenic acid derivatives for their polymerase inhibitor activity. Among them, seven compounds were PA(C) ligands, and four inhibited influenza RNA polymerase activity. These results aid in the design of anti-influenza agents based on caffeoylquinic acid.

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