Screen Anti-influenza Lead Compounds That Target the PA(C) Subunit of H5N1 Viral RNA Polymerase

The avian influenza (H5N1) viral RNA polymerase protein PA(C) was used as a target to screen nine chlorogenic acid derivatives for their polymerase inhibitor activity. Among them, seven compounds were PA(C) ligands, and four inhibited influenza RNA polymerase activity. These results aid in the desig...

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Detalles Bibliográficos
Autores principales: Li, Lin, Chang, Shenghai, Xiang, Junfeng, Li, Qian, Liang, Huanhuan, Tang, Yalin, Liu, Yingfang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3427309/
https://www.ncbi.nlm.nih.gov/pubmed/22936968
http://dx.doi.org/10.1371/journal.pone.0035234
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author Li, Lin
Chang, Shenghai
Xiang, Junfeng
Li, Qian
Liang, Huanhuan
Tang, Yalin
Liu, Yingfang
author_facet Li, Lin
Chang, Shenghai
Xiang, Junfeng
Li, Qian
Liang, Huanhuan
Tang, Yalin
Liu, Yingfang
author_sort Li, Lin
collection PubMed
description The avian influenza (H5N1) viral RNA polymerase protein PA(C) was used as a target to screen nine chlorogenic acid derivatives for their polymerase inhibitor activity. Among them, seven compounds were PA(C) ligands, and four inhibited influenza RNA polymerase activity. These results aid in the design of anti-influenza agents based on caffeoylquinic acid.
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spelling pubmed-34273092012-08-30 Screen Anti-influenza Lead Compounds That Target the PA(C) Subunit of H5N1 Viral RNA Polymerase Li, Lin Chang, Shenghai Xiang, Junfeng Li, Qian Liang, Huanhuan Tang, Yalin Liu, Yingfang PLoS One Research Article The avian influenza (H5N1) viral RNA polymerase protein PA(C) was used as a target to screen nine chlorogenic acid derivatives for their polymerase inhibitor activity. Among them, seven compounds were PA(C) ligands, and four inhibited influenza RNA polymerase activity. These results aid in the design of anti-influenza agents based on caffeoylquinic acid. Public Library of Science 2012-08-24 /pmc/articles/PMC3427309/ /pubmed/22936968 http://dx.doi.org/10.1371/journal.pone.0035234 Text en © 2012 Li et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Li, Lin
Chang, Shenghai
Xiang, Junfeng
Li, Qian
Liang, Huanhuan
Tang, Yalin
Liu, Yingfang
Screen Anti-influenza Lead Compounds That Target the PA(C) Subunit of H5N1 Viral RNA Polymerase
title Screen Anti-influenza Lead Compounds That Target the PA(C) Subunit of H5N1 Viral RNA Polymerase
title_full Screen Anti-influenza Lead Compounds That Target the PA(C) Subunit of H5N1 Viral RNA Polymerase
title_fullStr Screen Anti-influenza Lead Compounds That Target the PA(C) Subunit of H5N1 Viral RNA Polymerase
title_full_unstemmed Screen Anti-influenza Lead Compounds That Target the PA(C) Subunit of H5N1 Viral RNA Polymerase
title_short Screen Anti-influenza Lead Compounds That Target the PA(C) Subunit of H5N1 Viral RNA Polymerase
title_sort screen anti-influenza lead compounds that target the pa(c) subunit of h5n1 viral rna polymerase
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3427309/
https://www.ncbi.nlm.nih.gov/pubmed/22936968
http://dx.doi.org/10.1371/journal.pone.0035234
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