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Common variants at 12q14 and 12q24 are associated with hippocampal volume
Aging is associated with reductions in hippocampal volume (HV) that are accelerated by Alzheimer’s disease and vascular risk factors. Our genome-wide association study of dementia-free persons (n=9,232) identified 46 SNPs at four loci with p-values <4.0×10(-7). Two additional samples (n=2,318) re...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3427729/ https://www.ncbi.nlm.nih.gov/pubmed/22504421 http://dx.doi.org/10.1038/ng.2237 |
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| author | Bis, Joshua C. DeCarli, Charles Smith, Albert Vernon van der Lijn, Fedde Crivello, Fabrice Fornage, Myriam Debette, Stephanie Shulman, Joshua M. Schmidt, Helena Srikanth, Velandai Schuur, Maaike Yu, Lei Choi, Seung-Hoan Sigurdsson, Sigurdur Verhaaren, Benjamin F.J. DeStefano, Anita L. Lambert, Jean-Charles Jack, Clifford R. Struchalin, Maksim Stankovich, Jim Ibrahim-Verbaas, Carla A. Fleischman, Debra Zijdenbos, Alex den Heijer, Tom Mazoyer, Bernard Coker, Laura H. Enzinger, Christian Danoy, Patrick Amin, Najaf Arfanakis, Konstantinos van Buchem, Mark A. de Bruijn, Renée F.A.G. Beiser, Alexa Dufouil, Carole Huang, Juebin Cavalieri, Margherita Thomson, Russell Niessen, Wiro J. Chibnik, Lori B. Gislason, Gauti K. Hofman, Albert Pikula, Aleksandra Amouyel, Philippe Freeman, Kevin B. Phan, Thanh G. Oostra, Ben A. Stein, Jason L. Medland, Sarah E. Vasquez, Alejandro Arias Hibar, Derrek P. Wright, Margaret J. Franke, Barbara Martin, Nicholas G. Thompson, Paul M. Nalls, Michael A. Uitterlinden, Andre G. Au, Rhoda Elbaz, Alexis Beare, Richard J. van Swieten, John C. Lopez, Oscar Harris, Tamara B. Chouraki, Vincent Breteler, Monique M.B. De Jager, Philip L. Becker, James T. Vernooij, Meike W. Knopman, David Fazekas, Franz Wolf, Philip A. van der Lugt, Aad Gudnason, Vilmundur Longstreth, W.T. Brown, Mathew A. Bennett, David A. van Duijn, Cornelia M. Mosley, Thomas H. Schmidt, Reinhold Tzourio, Christophe Launer, Lenore J. Ikram, M. Arfan Seshadri, Sudha |
| author_facet | Bis, Joshua C. DeCarli, Charles Smith, Albert Vernon van der Lijn, Fedde Crivello, Fabrice Fornage, Myriam Debette, Stephanie Shulman, Joshua M. Schmidt, Helena Srikanth, Velandai Schuur, Maaike Yu, Lei Choi, Seung-Hoan Sigurdsson, Sigurdur Verhaaren, Benjamin F.J. DeStefano, Anita L. Lambert, Jean-Charles Jack, Clifford R. Struchalin, Maksim Stankovich, Jim Ibrahim-Verbaas, Carla A. Fleischman, Debra Zijdenbos, Alex den Heijer, Tom Mazoyer, Bernard Coker, Laura H. Enzinger, Christian Danoy, Patrick Amin, Najaf Arfanakis, Konstantinos van Buchem, Mark A. de Bruijn, Renée F.A.G. Beiser, Alexa Dufouil, Carole Huang, Juebin Cavalieri, Margherita Thomson, Russell Niessen, Wiro J. Chibnik, Lori B. Gislason, Gauti K. Hofman, Albert Pikula, Aleksandra Amouyel, Philippe Freeman, Kevin B. Phan, Thanh G. Oostra, Ben A. Stein, Jason L. Medland, Sarah E. Vasquez, Alejandro Arias Hibar, Derrek P. Wright, Margaret J. Franke, Barbara Martin, Nicholas G. Thompson, Paul M. Nalls, Michael A. Uitterlinden, Andre G. Au, Rhoda Elbaz, Alexis Beare, Richard J. van Swieten, John C. Lopez, Oscar Harris, Tamara B. Chouraki, Vincent Breteler, Monique M.B. De Jager, Philip L. Becker, James T. Vernooij, Meike W. Knopman, David Fazekas, Franz Wolf, Philip A. van der Lugt, Aad Gudnason, Vilmundur Longstreth, W.T. Brown, Mathew A. Bennett, David A. van Duijn, Cornelia M. Mosley, Thomas H. Schmidt, Reinhold Tzourio, Christophe Launer, Lenore J. Ikram, M. Arfan Seshadri, Sudha |
| author_sort | Bis, Joshua C. |
| collection | PubMed |
| description | Aging is associated with reductions in hippocampal volume (HV) that are accelerated by Alzheimer’s disease and vascular risk factors. Our genome-wide association study of dementia-free persons (n=9,232) identified 46 SNPs at four loci with p-values <4.0×10(-7). Two additional samples (n=2,318) replicated associations at 12q24 within MSRB3/WIF1 (discovery + replication, rs17178006; p=5.3×10(-11)) and at 12q14 near HRK/FBXW8 (rs7294919; p=2.9×10(-11)). Remaining associations included one 2q24 SNP within DPP4 (rs6741949; p=2.9×10(-7)) and nine 9p33 SNPs within ASTN2 (rs7852872; p=1.0×10(-7)) that were also associated with HV (p<0.05) in a third younger, more heterogeneous sample (n=7,794). The ASTN2 SNP was also associated with decline in cognition in a largely independent sample (n=1,563). These associations implicate genes related to apoptosis (HRK), development (WIF1), oxidative stress (MSR3B), ubiquitination (FBXW8), enzymes targeted by new diabetes medications (DPP4), and neuronal migration (ASTN2), indicating novel genetic influences that influence hippocampal size and possibly the risk of cognitive decline and dementia. |
| format | Online Article Text |
| id | pubmed-3427729 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2012 |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-34277292012-11-01 Common variants at 12q14 and 12q24 are associated with hippocampal volume Bis, Joshua C. DeCarli, Charles Smith, Albert Vernon van der Lijn, Fedde Crivello, Fabrice Fornage, Myriam Debette, Stephanie Shulman, Joshua M. Schmidt, Helena Srikanth, Velandai Schuur, Maaike Yu, Lei Choi, Seung-Hoan Sigurdsson, Sigurdur Verhaaren, Benjamin F.J. DeStefano, Anita L. Lambert, Jean-Charles Jack, Clifford R. Struchalin, Maksim Stankovich, Jim Ibrahim-Verbaas, Carla A. Fleischman, Debra Zijdenbos, Alex den Heijer, Tom Mazoyer, Bernard Coker, Laura H. Enzinger, Christian Danoy, Patrick Amin, Najaf Arfanakis, Konstantinos van Buchem, Mark A. de Bruijn, Renée F.A.G. Beiser, Alexa Dufouil, Carole Huang, Juebin Cavalieri, Margherita Thomson, Russell Niessen, Wiro J. Chibnik, Lori B. Gislason, Gauti K. Hofman, Albert Pikula, Aleksandra Amouyel, Philippe Freeman, Kevin B. Phan, Thanh G. Oostra, Ben A. Stein, Jason L. Medland, Sarah E. Vasquez, Alejandro Arias Hibar, Derrek P. Wright, Margaret J. Franke, Barbara Martin, Nicholas G. Thompson, Paul M. Nalls, Michael A. Uitterlinden, Andre G. Au, Rhoda Elbaz, Alexis Beare, Richard J. van Swieten, John C. Lopez, Oscar Harris, Tamara B. Chouraki, Vincent Breteler, Monique M.B. De Jager, Philip L. Becker, James T. Vernooij, Meike W. Knopman, David Fazekas, Franz Wolf, Philip A. van der Lugt, Aad Gudnason, Vilmundur Longstreth, W.T. Brown, Mathew A. Bennett, David A. van Duijn, Cornelia M. Mosley, Thomas H. Schmidt, Reinhold Tzourio, Christophe Launer, Lenore J. Ikram, M. Arfan Seshadri, Sudha Nat Genet Article Aging is associated with reductions in hippocampal volume (HV) that are accelerated by Alzheimer’s disease and vascular risk factors. Our genome-wide association study of dementia-free persons (n=9,232) identified 46 SNPs at four loci with p-values <4.0×10(-7). Two additional samples (n=2,318) replicated associations at 12q24 within MSRB3/WIF1 (discovery + replication, rs17178006; p=5.3×10(-11)) and at 12q14 near HRK/FBXW8 (rs7294919; p=2.9×10(-11)). Remaining associations included one 2q24 SNP within DPP4 (rs6741949; p=2.9×10(-7)) and nine 9p33 SNPs within ASTN2 (rs7852872; p=1.0×10(-7)) that were also associated with HV (p<0.05) in a third younger, more heterogeneous sample (n=7,794). The ASTN2 SNP was also associated with decline in cognition in a largely independent sample (n=1,563). These associations implicate genes related to apoptosis (HRK), development (WIF1), oxidative stress (MSR3B), ubiquitination (FBXW8), enzymes targeted by new diabetes medications (DPP4), and neuronal migration (ASTN2), indicating novel genetic influences that influence hippocampal size and possibly the risk of cognitive decline and dementia. 2012-04-15 /pmc/articles/PMC3427729/ /pubmed/22504421 http://dx.doi.org/10.1038/ng.2237 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms |
| spellingShingle | Article Bis, Joshua C. DeCarli, Charles Smith, Albert Vernon van der Lijn, Fedde Crivello, Fabrice Fornage, Myriam Debette, Stephanie Shulman, Joshua M. Schmidt, Helena Srikanth, Velandai Schuur, Maaike Yu, Lei Choi, Seung-Hoan Sigurdsson, Sigurdur Verhaaren, Benjamin F.J. DeStefano, Anita L. Lambert, Jean-Charles Jack, Clifford R. Struchalin, Maksim Stankovich, Jim Ibrahim-Verbaas, Carla A. Fleischman, Debra Zijdenbos, Alex den Heijer, Tom Mazoyer, Bernard Coker, Laura H. Enzinger, Christian Danoy, Patrick Amin, Najaf Arfanakis, Konstantinos van Buchem, Mark A. de Bruijn, Renée F.A.G. Beiser, Alexa Dufouil, Carole Huang, Juebin Cavalieri, Margherita Thomson, Russell Niessen, Wiro J. Chibnik, Lori B. Gislason, Gauti K. Hofman, Albert Pikula, Aleksandra Amouyel, Philippe Freeman, Kevin B. Phan, Thanh G. Oostra, Ben A. Stein, Jason L. Medland, Sarah E. Vasquez, Alejandro Arias Hibar, Derrek P. Wright, Margaret J. Franke, Barbara Martin, Nicholas G. Thompson, Paul M. Nalls, Michael A. Uitterlinden, Andre G. Au, Rhoda Elbaz, Alexis Beare, Richard J. van Swieten, John C. Lopez, Oscar Harris, Tamara B. Chouraki, Vincent Breteler, Monique M.B. De Jager, Philip L. Becker, James T. Vernooij, Meike W. Knopman, David Fazekas, Franz Wolf, Philip A. van der Lugt, Aad Gudnason, Vilmundur Longstreth, W.T. Brown, Mathew A. Bennett, David A. van Duijn, Cornelia M. Mosley, Thomas H. Schmidt, Reinhold Tzourio, Christophe Launer, Lenore J. Ikram, M. Arfan Seshadri, Sudha Common variants at 12q14 and 12q24 are associated with hippocampal volume |
| title | Common variants at 12q14 and 12q24 are associated with hippocampal volume |
| title_full | Common variants at 12q14 and 12q24 are associated with hippocampal volume |
| title_fullStr | Common variants at 12q14 and 12q24 are associated with hippocampal volume |
| title_full_unstemmed | Common variants at 12q14 and 12q24 are associated with hippocampal volume |
| title_short | Common variants at 12q14 and 12q24 are associated with hippocampal volume |
| title_sort | common variants at 12q14 and 12q24 are associated with hippocampal volume |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3427729/ https://www.ncbi.nlm.nih.gov/pubmed/22504421 http://dx.doi.org/10.1038/ng.2237 |
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