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Apn1 AP-endonuclease is essential for the repair of oxidatively damaged DNA bases in yeast frataxin-deficient cells

Frataxin deficiency results in mitochondrial dysfunction and oxidative stress and it is the cause of the hereditary neurodegenerative disease Friedreich ataxia (FA). Here, we present evidence that one of the pleiotropic effects of oxidative stress in frataxin-deficient yeast cells (Δyfh1 mutant) is...

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Detalles Bibliográficos
Autores principales:	Lefevre, Sophie, Brossas, Caroline, Auchère, Françoise, Boggetto, Nicole, Camadro, Jean-Michel, Santos, Renata
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2012
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3428155/ https://www.ncbi.nlm.nih.gov/pubmed/22706278 http://dx.doi.org/10.1093/hmg/dds230

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