Cationic lipid-coated PEI/DNA polyplexes with improved efficiency and reduced cytotoxicity for gene delivery into mesenchymal stem cells

BACKGROUND: Effective gene transfection without serum deprivation is a prerequisite for successful stem cell-based gene therapy. Polyethylenimine (PEI) is an efficient nonviral gene vector, but its application has been hindered by serum sensitivity and severe cytotoxicity. METHODS: To solve this pro...

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Detalles Bibliográficos
Autores principales: Song, Hongmei, Wang, Gang, He, Bin, Li, Li, Li, Caixia, Lai, Yusi, Xu, Xianghui, Gu, Zhongwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2012
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3428250/
https://www.ncbi.nlm.nih.gov/pubmed/22942645
http://dx.doi.org/10.2147/IJN.S33923

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3428250/
https://www.ncbi.nlm.nih.gov/pubmed/22942645
http://dx.doi.org/10.2147/IJN.S33923

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