Influence of Methylene Blue on Microglia-Induced Inflammation and Motor Neuron Degeneration in the SOD1(G93A) Model for ALS

Mutations in SOD1 cause hereditary variants of the fatal motor neuron disease amyotrophic lateral sclerosis (ALS). Pathophysiology of the disease is non-cell-autonomous, with toxicity deriving also from glia. In particular, microglia contribute to disease progression. Methylene blue (MB) inhibits th...

Descripción completa

Detalles Bibliográficos
Autores principales: Dibaj, Payam, Zschüntzsch, Jana, Steffens, Heinz, Scheffel, Jörg, Göricke, Bettina, Weishaupt, Jochen H., Le Meur, Karim, Kirchhoff, Frank, Hanisch, Uwe-Karsten, Schomburg, Eike D., Neusch, Clemens
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3428282/
https://www.ncbi.nlm.nih.gov/pubmed/22952827
http://dx.doi.org/10.1371/journal.pone.0043963

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3428282/
https://www.ncbi.nlm.nih.gov/pubmed/22952827
http://dx.doi.org/10.1371/journal.pone.0043963

Ejemplares similares