Targeted Ubiquitination and Degradation of G-Protein-Coupled Receptor Kinase 5 by the DDB1-CUL4 Ubiquitin Ligase Complex

The G protein-coupled receptor kinases (GRKs) phosphorylate agonist occupied G protein-coupled receptors (GPCRs) and desensitize GPCR-mediated signaling. Recent studies indicate they also function non-catalytically via interaction with other proteins. In this study, a proteomic approach was used to...

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Detalles Bibliográficos
Autores principales: Wu, Ziyan, Chen, Yuejun, Yang, Tong, Gao, Qinqin, Yuan, Man, Ma, Lan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3428324/
https://www.ncbi.nlm.nih.gov/pubmed/22952844
http://dx.doi.org/10.1371/journal.pone.0043997

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