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TFAP2B Influences the Effect of Dietary Fat on Weight Loss under Energy Restriction

BACKGROUND: Numerous gene loci are related to single measures of body weight and shape. We investigated if 55 SNPs previously associated with BMI or waist measures, modify the effects of fat intake on weight loss and waist reduction under energy restriction. METHODS AND FINDINGS: Randomized controll...

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Autores principales: Stocks, Tanja, Ängquist, Lars, Banasik, Karina, Harder, Marie N., Taylor, Moira A., Hager, Jörg, Arner, Peter, Oppert, Jean-Michel, Martinez, J. Alfredo, Polak, Jan, Rousseau, Francis, Langin, Dominique, Rössner, Stephan, Holst, Claus, MacDonald, Ian A., Kamatani, Yoichiro, Pfeiffer, Andreas F. H., Kunesova, Marie, Saris, Wim H. M., Hansen, Torben, Pedersen, Oluf, Astrup, Arne, Sørensen, Thorkild I. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3428346/
https://www.ncbi.nlm.nih.gov/pubmed/22952648
http://dx.doi.org/10.1371/journal.pone.0043212
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author Stocks, Tanja
Ängquist, Lars
Banasik, Karina
Harder, Marie N.
Taylor, Moira A.
Hager, Jörg
Arner, Peter
Oppert, Jean-Michel
Martinez, J. Alfredo
Polak, Jan
Rousseau, Francis
Langin, Dominique
Rössner, Stephan
Holst, Claus
MacDonald, Ian A.
Kamatani, Yoichiro
Pfeiffer, Andreas F. H.
Kunesova, Marie
Saris, Wim H. M.
Hansen, Torben
Pedersen, Oluf
Astrup, Arne
Sørensen, Thorkild I. A.
author_facet Stocks, Tanja
Ängquist, Lars
Banasik, Karina
Harder, Marie N.
Taylor, Moira A.
Hager, Jörg
Arner, Peter
Oppert, Jean-Michel
Martinez, J. Alfredo
Polak, Jan
Rousseau, Francis
Langin, Dominique
Rössner, Stephan
Holst, Claus
MacDonald, Ian A.
Kamatani, Yoichiro
Pfeiffer, Andreas F. H.
Kunesova, Marie
Saris, Wim H. M.
Hansen, Torben
Pedersen, Oluf
Astrup, Arne
Sørensen, Thorkild I. A.
author_sort Stocks, Tanja
collection PubMed
description BACKGROUND: Numerous gene loci are related to single measures of body weight and shape. We investigated if 55 SNPs previously associated with BMI or waist measures, modify the effects of fat intake on weight loss and waist reduction under energy restriction. METHODS AND FINDINGS: Randomized controlled trial of 771 obese adults. (Registration: ISRCTN25867281.) One SNP was selected for replication in another weight loss intervention study of 934 obese adults. The original trial was a 10-week 600 kcal/d energy-deficient diet with energy percentage from fat (fat%) in range of 20–25 or 40–45. The replication study used an 8-weeks diet of 880 kcal/d and 20 fat%; change in fat% intake was used for estimation of interaction effects. The main outcomes were intervention weight loss and waist reduction. In the trial, mean change in fat% intake was −12/+4 in the low/high-fat groups. In the replication study, it was −23/−12 among those reducing fat% more/less than the median. TFAP2B-rs987237 genotype AA was associated with 1.0 kg (95% CI, 0.4; 1.6) greater weight loss on the low-fat, and GG genotype with 2.6 kg (1.1; 4.1) greater weight loss on the high-fat (interaction p-value; p = 0.00007). The replication study showed a similar (non-significant) interaction pattern. Waist reduction results generally were similar. Study-strengths include (i) the discovery study randomised trial design combined with the replication opportunity (ii) the strict dietary intake control in both studies (iii) the large sample sizes of both studies. Limitations are (i) the low minor allele frequency of the TFAP2B polymorphism, making it hard to investigate non-additive genetic effects (ii) the different interventions preventing identical replication-discovery study designs (iii) some missing data for non-completers and dietary intake. No adverse effects/outcomes or side-effects were observed. CONCLUSIONS: Under energy restriction, TFAP2B may modify the effect of dietary fat intake on weight loss and waist reduction.
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spelling pubmed-34283462012-09-05 TFAP2B Influences the Effect of Dietary Fat on Weight Loss under Energy Restriction Stocks, Tanja Ängquist, Lars Banasik, Karina Harder, Marie N. Taylor, Moira A. Hager, Jörg Arner, Peter Oppert, Jean-Michel Martinez, J. Alfredo Polak, Jan Rousseau, Francis Langin, Dominique Rössner, Stephan Holst, Claus MacDonald, Ian A. Kamatani, Yoichiro Pfeiffer, Andreas F. H. Kunesova, Marie Saris, Wim H. M. Hansen, Torben Pedersen, Oluf Astrup, Arne Sørensen, Thorkild I. A. PLoS One Research Article BACKGROUND: Numerous gene loci are related to single measures of body weight and shape. We investigated if 55 SNPs previously associated with BMI or waist measures, modify the effects of fat intake on weight loss and waist reduction under energy restriction. METHODS AND FINDINGS: Randomized controlled trial of 771 obese adults. (Registration: ISRCTN25867281.) One SNP was selected for replication in another weight loss intervention study of 934 obese adults. The original trial was a 10-week 600 kcal/d energy-deficient diet with energy percentage from fat (fat%) in range of 20–25 or 40–45. The replication study used an 8-weeks diet of 880 kcal/d and 20 fat%; change in fat% intake was used for estimation of interaction effects. The main outcomes were intervention weight loss and waist reduction. In the trial, mean change in fat% intake was −12/+4 in the low/high-fat groups. In the replication study, it was −23/−12 among those reducing fat% more/less than the median. TFAP2B-rs987237 genotype AA was associated with 1.0 kg (95% CI, 0.4; 1.6) greater weight loss on the low-fat, and GG genotype with 2.6 kg (1.1; 4.1) greater weight loss on the high-fat (interaction p-value; p = 0.00007). The replication study showed a similar (non-significant) interaction pattern. Waist reduction results generally were similar. Study-strengths include (i) the discovery study randomised trial design combined with the replication opportunity (ii) the strict dietary intake control in both studies (iii) the large sample sizes of both studies. Limitations are (i) the low minor allele frequency of the TFAP2B polymorphism, making it hard to investigate non-additive genetic effects (ii) the different interventions preventing identical replication-discovery study designs (iii) some missing data for non-completers and dietary intake. No adverse effects/outcomes or side-effects were observed. CONCLUSIONS: Under energy restriction, TFAP2B may modify the effect of dietary fat intake on weight loss and waist reduction. Public Library of Science 2012-08-27 /pmc/articles/PMC3428346/ /pubmed/22952648 http://dx.doi.org/10.1371/journal.pone.0043212 Text en © 2012 Stocks et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Stocks, Tanja
Ängquist, Lars
Banasik, Karina
Harder, Marie N.
Taylor, Moira A.
Hager, Jörg
Arner, Peter
Oppert, Jean-Michel
Martinez, J. Alfredo
Polak, Jan
Rousseau, Francis
Langin, Dominique
Rössner, Stephan
Holst, Claus
MacDonald, Ian A.
Kamatani, Yoichiro
Pfeiffer, Andreas F. H.
Kunesova, Marie
Saris, Wim H. M.
Hansen, Torben
Pedersen, Oluf
Astrup, Arne
Sørensen, Thorkild I. A.
TFAP2B Influences the Effect of Dietary Fat on Weight Loss under Energy Restriction
title TFAP2B Influences the Effect of Dietary Fat on Weight Loss under Energy Restriction
title_full TFAP2B Influences the Effect of Dietary Fat on Weight Loss under Energy Restriction
title_fullStr TFAP2B Influences the Effect of Dietary Fat on Weight Loss under Energy Restriction
title_full_unstemmed TFAP2B Influences the Effect of Dietary Fat on Weight Loss under Energy Restriction
title_short TFAP2B Influences the Effect of Dietary Fat on Weight Loss under Energy Restriction
title_sort tfap2b influences the effect of dietary fat on weight loss under energy restriction
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3428346/
https://www.ncbi.nlm.nih.gov/pubmed/22952648
http://dx.doi.org/10.1371/journal.pone.0043212
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