Autoproteolytic Activation of ThnT Results in Structural Reorganization Necessary for Substrate Binding and Catalysis

cis-Autoproteolysis is a post-translational modification necessary for the function of ThnT, an enzyme involved in the biosynthesis of the β-lactam antibiotic thienamycin. This modification generates an N-terminal threonine nucleophile that is used to hydrolyze the pantetheinyl moiety of its natural...

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Detalles Bibliográficos
Autores principales: Buller, Andrew R., Labonte, Jason W., Freeman, Michael F., Wright, Nathan T., Schildbach, Joel F., Townsend, Craig A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3428426/
https://www.ncbi.nlm.nih.gov/pubmed/22706025
http://dx.doi.org/10.1016/j.jmb.2012.06.012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3428426/
https://www.ncbi.nlm.nih.gov/pubmed/22706025
http://dx.doi.org/10.1016/j.jmb.2012.06.012

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