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Executive Functions in Chronic Mesial Temporal Lobe Epilepsy
There is no consensus as to whether mesial temporal lobe epilepsy (MTLE) leads to executive function deficits. In this study, we adopted an extensive neuropsychological test battery and assessed different executive functions in chronic, unilateral MTLE. Performance of MTLE patients was compared with...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3428608/ https://www.ncbi.nlm.nih.gov/pubmed/22937233 http://dx.doi.org/10.1155/2011/596174 |
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author | Zamarian, Laura Trinka, Eugen Bonatti, Elisabeth Kuchukhidze, Giorgi Bodner, Thomas Benke, Thomas Koppelstaetter, Florian Delazer, Margarete |
author_facet | Zamarian, Laura Trinka, Eugen Bonatti, Elisabeth Kuchukhidze, Giorgi Bodner, Thomas Benke, Thomas Koppelstaetter, Florian Delazer, Margarete |
author_sort | Zamarian, Laura |
collection | PubMed |
description | There is no consensus as to whether mesial temporal lobe epilepsy (MTLE) leads to executive function deficits. In this study, we adopted an extensive neuropsychological test battery and assessed different executive functions in chronic, unilateral MTLE. Performance of MTLE patients was compared with that of healthy peers and with normative data. Several MTLE patients had scores below cut-off or below the 10th percentile of normative data. Scores of the whole patient group were overall in the average range of normative data. Relative to controls, MTLE patients performed poorly in tests of working memory, cognitive flexibility, categorical verbal fluency, set-shifting, categorization, and planning. These findings raise an important methodological issue as they suggest that executive function deficits in chronic MTLE may be individually variable and that their assessment should include different tests. Deficits in chronic MTLE are not limited to temporal lobe functions, such as memory, but may extend to extra temporal cognitive domains, such as executive functions. |
format | Online Article Text |
id | pubmed-3428608 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-34286082012-08-30 Executive Functions in Chronic Mesial Temporal Lobe Epilepsy Zamarian, Laura Trinka, Eugen Bonatti, Elisabeth Kuchukhidze, Giorgi Bodner, Thomas Benke, Thomas Koppelstaetter, Florian Delazer, Margarete Epilepsy Res Treat Research Article There is no consensus as to whether mesial temporal lobe epilepsy (MTLE) leads to executive function deficits. In this study, we adopted an extensive neuropsychological test battery and assessed different executive functions in chronic, unilateral MTLE. Performance of MTLE patients was compared with that of healthy peers and with normative data. Several MTLE patients had scores below cut-off or below the 10th percentile of normative data. Scores of the whole patient group were overall in the average range of normative data. Relative to controls, MTLE patients performed poorly in tests of working memory, cognitive flexibility, categorical verbal fluency, set-shifting, categorization, and planning. These findings raise an important methodological issue as they suggest that executive function deficits in chronic MTLE may be individually variable and that their assessment should include different tests. Deficits in chronic MTLE are not limited to temporal lobe functions, such as memory, but may extend to extra temporal cognitive domains, such as executive functions. Hindawi Publishing Corporation 2011 2011-03-06 /pmc/articles/PMC3428608/ /pubmed/22937233 http://dx.doi.org/10.1155/2011/596174 Text en Copyright © 2011 Laura Zamarian et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Zamarian, Laura Trinka, Eugen Bonatti, Elisabeth Kuchukhidze, Giorgi Bodner, Thomas Benke, Thomas Koppelstaetter, Florian Delazer, Margarete Executive Functions in Chronic Mesial Temporal Lobe Epilepsy |
title | Executive Functions in Chronic Mesial Temporal Lobe Epilepsy |
title_full | Executive Functions in Chronic Mesial Temporal Lobe Epilepsy |
title_fullStr | Executive Functions in Chronic Mesial Temporal Lobe Epilepsy |
title_full_unstemmed | Executive Functions in Chronic Mesial Temporal Lobe Epilepsy |
title_short | Executive Functions in Chronic Mesial Temporal Lobe Epilepsy |
title_sort | executive functions in chronic mesial temporal lobe epilepsy |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3428608/ https://www.ncbi.nlm.nih.gov/pubmed/22937233 http://dx.doi.org/10.1155/2011/596174 |
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