Cargando…

Lung Function Measurements in Rodents in Safety Pharmacology Studies

The ICH guideline S7A requires safety pharmacology tests including measurements of pulmonary function. In the first step – as part of the “core battery” – lung function tests in conscious animals are requested. If potential adverse effects raise concern for human safety, these should be explored in...

Descripción completa

Detalles Bibliográficos
Autor principal:	Hoymann, Heinz Gerd
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Research Foundation 2012
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3428707/ https://www.ncbi.nlm.nih.gov/pubmed/22973226 http://dx.doi.org/10.3389/fphar.2012.00156

Ejemplares similares

The power of using functional fMRI on small rodents to study brain pharmacology and disease
por: Jonckers, Elisabeth, et al.
Publicado: (2015)

Experimental Pharmacology in Transgenic Rodent Models of Alzheimer’s Disease
por: Cuello, A. Claudio, et al.
Publicado: (2019)

Pharmacological effects of baicalin in lung diseases
por: Wang, Duoning, et al.
Publicado: (2023)

Impaired anti-viral immune response to human rhinovirus 1B infection in chronic allergic airway inflammation does not manifest in asthma exacerbation
por: Rochlitzer, Sabine, et al.
Publicado: (2013)

Preclinical safety evaluation of Macleaya Cordata extract: A re-assessment of general toxicity and genotoxicity properties in rodents
por: Dong, Zhen, et al.
Publicado: (2022)

FGF21 Analogs of Sustained Action Enabled by Orthogonal Biosynthesis Demonstrate Enhanced Antidiabetic Pharmacology in Rodents
por: Mu, James, et al.
Publicado: (2012)

Rodent models to study the metabolic effects of shiftwork in humans
por: Opperhuizen, Anne-Loes, et al.
Publicado: (2015)

Andrographolide Against Lung Cancer-New Pharmacological Insights Based on High-Throughput Metabolomics Analysis Combined with Network Pharmacology
por: Luo, Wen, et al.
Publicado: (2021)

Cinnamomum Species: Bridging Phytochemistry Knowledge, Pharmacological Properties and Toxicological Safety for Health Benefits
por: Sharifi-Rad, Javad, et al.
Publicado: (2021)

Sleep Disorders in Rodent Models of Parkinson’s Disease
por: Medeiros, Daniel de Castro, et al.
Publicado: (2019)

Safety Pharmacology Study of ET-26 Hydrochloride, a Potential Drug for Intravenous General Anesthesia, in Rats and Beagle Dogs
por: Zhang, YuJun, et al.
Publicado: (2021)

Editorial: Venoms and Toxins: Functional Omics and Pharmacological Insights
por: Tan, Choo Hock, et al.
Publicado: (2022)

Trends in Qualifying Biomarkers in Drug Safety. Consensus of the 2011 Meeting of the Spanish Society of Clinical Pharmacology
por: Agúndez, José A. G., et al.
Publicado: (2012)

Editorial: Be positive about the negative in pharmacology: clinical studies in renal pharmacology 2022
por: Prasad, Narayan, et al.
Publicado: (2023)

Resveratrol in Rodent Models of Parkinson’s Disease: A Systematic Review of Experimental Studies
por: Su, Cheng-Fu, et al.
Publicado: (2021)

Antiparkinsonian Efficacy of Guanosine in Rodent Models of Movement Disorder
por: Massari, Caio M., et al.
Publicado: (2017)

Pharmacological Insights Into Safety and Efficacy Determinants for the Development of Adenosine Receptor Biased Agonists in the Treatment of Heart Failure
por: Rueda, Patricia, et al.
Publicado: (2021)

Research Advances in Pharmacology, Safety, and Clinical Applications of Yunnan Baiyao, a Traditional Chinese Medicine Formula
por: Yao, Qi, et al.
Publicado: (2021)

Efficacy and safety of pharmacological interventions for pruritus in primary biliary cholangitis: A systematic review and meta-analysis
por: Xu, Chenyi, et al.
Publicado: (2022)

Pharmacological Modulation of Endotoxin-Induced Release of IL-26 in Human Primary Lung Fibroblasts
por: Che, Karlhans Fru, et al.
Publicado: (2019)

Effect of ouabain on calcium signaling in rodent brain: A systematic review of in vitro studies
por: Leite, Jacqueline Alves, et al.
Publicado: (2022)

Advances in optical imaging for pharmacological studies
por: Arranz, Alicia, et al.
Publicado: (2015)

Rodent Lethality Models Are Problematic for Evaluating Antivenoms for Human Envenoming
por: Silva, Anjana, et al.
Publicado: (2022)

Functional and Pharmacological Characterization of the Rare CFTR Mutation W361R
por: Billet, Arnaud, et al.
Publicado: (2020)

Uncovering the Pharmacological Mechanism of 2-Dodecyl-6-Methoxycyclohexa-2,5 -Diene-1,4-Dione Against Lung Cancer Based on Network Pharmacology and Experimental Evaluation
por: Wang, Lihui, et al.
Publicado: (2021)

Translational Pharmacology
por: Stewart, Alastair G.
Publicado: (2017)

Overexpression of cathepsin K in mice decreases collagen deposition and lung resistance in response to bleomycin-induced pulmonary fibrosis
por: Srivastava, Mrigank, et al.
Publicado: (2008)

Deciphering the Pharmacological Mechanisms of the Huayu-Qiangshen-Tongbi Formula Through Integrating Network Pharmacology and In Vitro Pharmacological Investigation
por: Wang, Zihao, et al.
Publicado: (2019)

Unraveling the Pharmacological Potential of Lichen Extracts in the Context of Cancer and Inflammation With a Broad Screening Approach
por: Ingelfinger, Rebecca, et al.
Publicado: (2020)

Safety of Off-Label Pharmacological Treatment in Pediatric Neuropsychiatric Disorders: A Global Perspective From an Observational Study at an Italian Third Level Children’s Hospital
por: Giurin, Maria Sole, et al.
Publicado: (2022)

Antidepressant Effects of NSAIDs in Rodent Models of Depression—A Systematic Review
por: Bay-Richter, Cecilie, et al.
Publicado: (2022)

Preclinical Evaluation of Fingolimod in Rodent Models of Stroke With Age or Atherosclerosis as Comorbidities
por: Diaz Diaz, Andrea C., et al.
Publicado: (2022)

Social housing of non-rodents during cardiovascular recordings in safety pharmacology and toxicology studies
por: Prior, Helen, et al.
Publicado: (2016)

Wenxin Keli for the Treatment of Arrhythmia—Systems Pharmacology and In Vivo Pharmacological Assessment
por: Li, Xiaofeng, et al.
Publicado: (2021)

Editorial: Emerging talents in Frontiers in pharmacology: Gastrointestinal and hepatic pharmacology 2022
por: Grasa, Laura, et al.
Publicado: (2022)

Editorial: Emerging researchers in frontiers in pharmacology: obstetric and pediatric pharmacology 2022
por: Yang, Qiwei, et al.
Publicado: (2023)

Quantification of Lung Fibrosis in IPF-Like Mouse Model and Pharmacological Response to Treatment by Micro-Computed Tomography
por: Ruscitti, Francesca, et al.
Publicado: (2020)

Frontiers in Pharmacology: Review Manuscript Targeting of the Neutrophil as an Adjunctive Strategy in Non-Small Cell Lung Cancer
por: Anderson, Ronald, et al.
Publicado: (2021)

To explore the effect of kaempferol on non-small cell lung cancer based on network pharmacology and molecular docking
por: Zhang, Junli, et al.
Publicado: (2023)

Acute, chronic, and genotoxic studies on the protopine total alkaloids of the Macleaya cordata (willd.) R. Br. in rodents
por: Dong, Zhen, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_t8ig24pc736tef0oncmg8i7baj