Cargando…
Pathogenic mechanism of second hand smoke induced inflammation and COPD
Second hand smoke (SHS) introduces thousands of toxic chemicals into the lung, including carcinogens and oxidants, which cause direct airway epithelium tissue destruction. It can also illicit indirect damage through its effect on signaling pathways related to tissue cell repair and by the abnormal i...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3428782/ https://www.ncbi.nlm.nih.gov/pubmed/22973236 http://dx.doi.org/10.3389/fphys.2012.00348 |
_version_ | 1782241735161675776 |
---|---|
author | Birru, Rahel L. Di, Y. Peter |
author_facet | Birru, Rahel L. Di, Y. Peter |
author_sort | Birru, Rahel L. |
collection | PubMed |
description | Second hand smoke (SHS) introduces thousands of toxic chemicals into the lung, including carcinogens and oxidants, which cause direct airway epithelium tissue destruction. It can also illicit indirect damage through its effect on signaling pathways related to tissue cell repair and by the abnormal induction of inflammation into the lung. After repeated exposure to SHS, these symptoms can lead to the development of pulmonary inflammatory disorders, including chronic obstructive pulmonary disease (COPD). COPD is a severe pulmonary disease characterized by chronic inflammation and irreversible tissue destruction. There is no causal cure, as the mechanism behind the development and progression of the disease is still unknown. Recent discoveries implicate genetic predisposition associated with inflammatory response contributed to the development of COPD, linked to irregular innate and adaptive immunity, as well as a risk factor for cancer. The use of animal models for both cigarette smoke (CS) and SHS associated in vivo experiments has been crucial in elucidating the pathogenic mechanisms and genetic components involved in inflammation-related development of COPD. |
format | Online Article Text |
id | pubmed-3428782 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-34287822012-09-12 Pathogenic mechanism of second hand smoke induced inflammation and COPD Birru, Rahel L. Di, Y. Peter Front Physiol Physiology Second hand smoke (SHS) introduces thousands of toxic chemicals into the lung, including carcinogens and oxidants, which cause direct airway epithelium tissue destruction. It can also illicit indirect damage through its effect on signaling pathways related to tissue cell repair and by the abnormal induction of inflammation into the lung. After repeated exposure to SHS, these symptoms can lead to the development of pulmonary inflammatory disorders, including chronic obstructive pulmonary disease (COPD). COPD is a severe pulmonary disease characterized by chronic inflammation and irreversible tissue destruction. There is no causal cure, as the mechanism behind the development and progression of the disease is still unknown. Recent discoveries implicate genetic predisposition associated with inflammatory response contributed to the development of COPD, linked to irregular innate and adaptive immunity, as well as a risk factor for cancer. The use of animal models for both cigarette smoke (CS) and SHS associated in vivo experiments has been crucial in elucidating the pathogenic mechanisms and genetic components involved in inflammation-related development of COPD. Frontiers Media S.A. 2012-08-28 /pmc/articles/PMC3428782/ /pubmed/22973236 http://dx.doi.org/10.3389/fphys.2012.00348 Text en Copyright © 2012 Birru and Di. http://www.frontiersin.org/licenseagreement This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc. |
spellingShingle | Physiology Birru, Rahel L. Di, Y. Peter Pathogenic mechanism of second hand smoke induced inflammation and COPD |
title | Pathogenic mechanism of second hand smoke induced inflammation and COPD |
title_full | Pathogenic mechanism of second hand smoke induced inflammation and COPD |
title_fullStr | Pathogenic mechanism of second hand smoke induced inflammation and COPD |
title_full_unstemmed | Pathogenic mechanism of second hand smoke induced inflammation and COPD |
title_short | Pathogenic mechanism of second hand smoke induced inflammation and COPD |
title_sort | pathogenic mechanism of second hand smoke induced inflammation and copd |
topic | Physiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3428782/ https://www.ncbi.nlm.nih.gov/pubmed/22973236 http://dx.doi.org/10.3389/fphys.2012.00348 |
work_keys_str_mv | AT birrurahell pathogenicmechanismofsecondhandsmokeinducedinflammationandcopd AT diypeter pathogenicmechanismofsecondhandsmokeinducedinflammationandcopd |