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Direct inhibition of the cold-activated TRPM8 ion channel by Gα(q)

Activation of the TRPM8 ion channel in sensory nerve endings produces a sensation of pleasant coolness. Here we show that inflammatory mediators such as bradykinin and histamine inhibit TRPM8 in intact sensory nerves, but do not do so via conventional signalling pathways. The G-protein subunit Ga(q)...

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Detalles Bibliográficos
Autores principales:	Zhang, Xuming, Mak, Stephanie, Li, Lin, Parra, Andres, Denlinger, Bristol, Belmonte, Carlos, McNaughton, Peter A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2012
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3428855/ https://www.ncbi.nlm.nih.gov/pubmed/22750945 http://dx.doi.org/10.1038/ncb2529

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